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Bdnf brain derived neurotrophic factor [ Mus musculus (house mouse) ]

Gene ID: 12064, updated on 22-Dec-2014
Official Symbol
Bdnfprovided by MGI
Official Full Name
brain derived neurotrophic factorprovided by MGI
Primary source
MGI:MGI:88145
Locus tag
RP23-393E8.1
See related
Ensembl:ENSMUSG00000048482; Vega:OTTMUSG00000015122
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
See Bdnf in Epigenomics, MapViewer
Location:
2 E3; 2 56.63 cM
Exon count:
9
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 2 NC_000068.7 (109674700..109727043)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene methyltransferase like 15 Neighboring gene kinesin family member 18A Neighboring gene ribosomal protein L17 pseudogene Neighboring gene high mobility group box 2 pseudogene Neighboring gene lin-7 homolog C (C. elegans)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Alcoholism, organism-specific biosystem (from KEGG)
    Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • Alcoholism, conserved biosystem (from KEGG)
    Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • Cocaine addiction, organism-specific biosystem (from KEGG)
    Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • Cocaine addiction, conserved biosystem (from KEGG)
    Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
neurotrophin TRKB receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
neurotrophin TRKB receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
axon extension IDA
Inferred from Direct Assay
more info
PubMed 
axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
axon target recognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendrite extension IDA
Inferred from Direct Assay
more info
PubMed 
fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
gamma-aminobutyric acid signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
glutamate secretion IPI
Inferred from Physical Interaction
more info
PubMed 
inner ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning ISO
Inferred from Sequence Orthology
more info
 
learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
mechanoreceptor differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
mitochondrial electron transport, NADH to ubiquinone ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of striated muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of synaptic transmission, GABAergic IDA
Inferred from Direct Assay
more info
PubMed 
nerve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development ISO
Inferred from Sequence Orthology
more info
 
neuron projection extension ISO
Inferred from Sequence Orthology
more info
 
neuron recognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glucocorticoid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
regulation of excitatory postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
regulation of inhibitory postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
regulation of metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of retinal cell programmed cell death IDA
Inferred from Direct Assay
more info
PubMed 
regulation of short-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic plasticity IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IMP
Inferred from Mutant Phenotype
more info
PubMed 
taste bud development IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
ureteric bud development IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
cell IPI
Inferred from Physical Interaction
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic membrane-bounded vesicle IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
mitochondrial crista ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
brain-derived neurotrophic factor
Names
brain-derived neurotrophic factor
anorexia BDNF

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048139.1NP_001041604.1  brain-derived neurotrophic factor isoform 2 precursor

    See proteins identical to NP_001041604.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 encode the same protein.
    Source sequence(s)
    AL732477, AY057911
    Consensus CDS
    CCDS38194.1
    UniProtKB/Swiss-Prot
    P21237
    UniProtKB/TrEMBL
    Q541P3
    Related
    ENSMUSP00000106680, OTTMUSP00000016088, ENSMUST00000111051, OTTMUST00000035863
    Conserved Domains (1) summary
    pfam00243
    Location:132249
    NGF; Nerve growth factor family
  2. NM_001048141.1NP_001041606.1  brain-derived neurotrophic factor isoform 2 precursor

    See proteins identical to NP_001041606.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 encode the same protein.
    Source sequence(s)
    AL732477, AY057913
    Consensus CDS
    CCDS38194.1
    UniProtKB/Swiss-Prot
    P21237
    UniProtKB/TrEMBL
    Q541P3
    Related
    ENSMUSP00000106679, OTTMUSP00000016092, ENSMUST00000111050, OTTMUST00000035867
    Conserved Domains (1) summary
    pfam00243
    Location:132249
    NGF; Nerve growth factor family
  3. NM_001048142.1NP_001041607.1  brain-derived neurotrophic factor isoform 2 precursor

    See proteins identical to NP_001041607.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 encode the same protein.
    Source sequence(s)
    AL732477, AY057914
    Consensus CDS
    CCDS38194.1
    UniProtKB/Swiss-Prot
    P21237
    UniProtKB/TrEMBL
    Q541P3
    Related
    ENSMUSP00000106674, OTTMUSP00000016093, ENSMUST00000111045, OTTMUST00000035868
    Conserved Domains (1) summary
    pfam00243
    Location:132249
    NGF; Nerve growth factor family
  4. NM_001285416.1NP_001272345.1  brain-derived neurotrophic factor isoform 2 precursor

    See proteins identical to NP_001272345.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 encode the same protein.
    Source sequence(s)
    AL732477, AY057910
    Consensus CDS
    CCDS38194.1
    UniProtKB/Swiss-Prot
    P21237
    UniProtKB/TrEMBL
    Q541P3
    Related
    ENSMUSP00000106676, OTTMUSP00000016089, ENSMUST00000111047, OTTMUST00000035864
    Conserved Domains (1) summary
    pfam00243
    Location:132249
    NGF; Nerve growth factor family
  5. NM_001285417.1NP_001272346.1  brain-derived neurotrophic factor isoform 2 precursor

    See proteins identical to NP_001272346.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 encode the same protein.
    Source sequence(s)
    AL732477, AY231131
    Consensus CDS
    CCDS38194.1
    UniProtKB/Swiss-Prot
    P21237
    UniProtKB/TrEMBL
    Q541P3
    Related
    ENSMUSP00000106672, OTTMUSP00000016095, ENSMUST00000111043, OTTMUST00000035870
    Conserved Domains (1) summary
    pfam00243
    Location:132249
    NGF; Nerve growth factor family
  6. NM_001285418.1NP_001272347.1  brain-derived neurotrophic factor isoform 2 precursor

    See proteins identical to NP_001272347.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 encode the same protein.
    Source sequence(s)
    AL732477, AY057909
    Consensus CDS
    CCDS38194.1
    UniProtKB/Swiss-Prot
    P21237
    UniProtKB/TrEMBL
    Q541P3
    Related
    ENSMUSP00000106678, OTTMUSP00000016090, ENSMUST00000111049, OTTMUST00000035865
    Conserved Domains (1) summary
    pfam00243
    Location:132249
    NGF; Nerve growth factor family
  7. NM_001285419.1NP_001272348.1  brain-derived neurotrophic factor isoform 2 precursor

    See proteins identical to NP_001272348.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 encode the same protein.
    Source sequence(s)
    AL732477, AY057912
    Consensus CDS
    CCDS38194.1
    UniProtKB/Swiss-Prot
    P21237
    UniProtKB/TrEMBL
    Q541P3
    Related
    ENSMUSP00000106675, OTTMUSP00000016091, ENSMUST00000111046, OTTMUST00000035866
    Conserved Domains (1) summary
    pfam00243
    Location:132249
    NGF; Nerve growth factor family
  8. NM_001285420.1NP_001272349.1  brain-derived neurotrophic factor isoform 2 precursor

    See proteins identical to NP_001272349.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 encode the same protein.
    Source sequence(s)
    AL732477
    Consensus CDS
    CCDS38194.1
    UniProtKB/Swiss-Prot
    P21237
    UniProtKB/TrEMBL
    Q541P3
    Related
    ENSMUSP00000135762, OTTMUSP00000056673, ENSMUST00000176893, OTTMUST00000101213
    Conserved Domains (1) summary
    pfam00243
    Location:132249
    NGF; Nerve growth factor family
  9. NM_001285421.1NP_001272350.1  brain-derived neurotrophic factor isoform 2 precursor

    See proteins identical to NP_001272350.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 encode the same protein.
    Source sequence(s)
    AL732477
    Consensus CDS
    CCDS38194.1
    UniProtKB/Swiss-Prot
    P21237
    UniProtKB/TrEMBL
    Q541P3
    Conserved Domains (1) summary
    pfam00243
    Location:132249
    NGF; Nerve growth factor family
  10. NM_001285422.1NP_001272351.1  brain-derived neurotrophic factor isoform 2 precursor

    See proteins identical to NP_001272351.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 encode the same protein.
    Source sequence(s)
    AL732477
    Consensus CDS
    CCDS38194.1
    UniProtKB/Swiss-Prot
    P21237
    UniProtKB/TrEMBL
    Q541P3
    Conserved Domains (1) summary
    pfam00243
    Location:132249
    NGF; Nerve growth factor family
  11. NM_007540.4NP_031566.4  brain-derived neurotrophic factor isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AL732477, AY057908
    Consensus CDS
    CCDS38193.1
    UniProtKB/TrEMBL
    A2AII2
    UniProtKB/TrEMBL
    Q541P3
    Related
    ENSMUSP00000057989, OTTMUSP00000016087, ENSMUST00000053317, OTTMUST00000035862
    Conserved Domains (1) summary
    pfam00243
    Location:140257
    NGF; Nerve growth factor family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000068.7 

    Range
    109674700..109727043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000024.1 

    Range
    110835441..110887723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)