IL7 interleukin 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL7provided by HGNC
Official Full Name: interleukin 7provided by HGNC
Primary source: HGNC:HGNC:6023
See related: Ensembl:ENSG00000104432 MIM:146660; AllianceGenome:HGNC:6023
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IL-7
Summary: The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL7 is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. IL7 plays an essential role in lymphoid cell survival, and in the maintenance of naive and memory T cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can be a potent inducer of proinflammatory cytokines and chemokines which may defend against the infection, but may also mediate destructive lung injury. Elevated serum IL7 levels, together with several other circulating cytokines and chemokines, has been found to be associated with the severity of Coronavirus Disease 19 (COVID-19). [provided by RefSeq, Jul 2020]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Expression: Broad expression in lymph node (RPKM 2.7), skin (RPKM 2.5) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q21.13

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (78675044..78805463, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (79106579..79236843, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (79645007..79717698, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-7 receptor signaling drives human B-cell progenitor differentiation and expansion.
Title: IL-7 receptor signaling drives human B-cell progenitor differentiation and expansion.
The Therapeutic Values of IL-7/IL-7R and the Recombinant Derivatives in Glioma: A Narrative Review.
Title: The Therapeutic Values of IL-7/IL-7R and the Recombinant Derivatives in Glioma: A Narrative Review.
Tear levels of IL-7, IL-1alpha, and IL-1beta may differentiate between IgG4-related disease and Sjogren's syndrome.
Title: Tear levels of IL-7, IL-1α, and IL-1β may differentiate between IgG4-related disease and Sjögren's syndrome.
IL-7 germline variant: setting the stage for immune-related adverse events.
Title: IL-7 germline variant: setting the stage for immune-related adverse events.
IL-7 and IL-7R in health and disease: An update through COVID times.
Title: IL-7 and IL-7R in health and disease: An update through COVID times.
LncRNA OIP5-AS1 modulates the proliferation and apoptosis of Jurkat cells by sponging miR-181c-5p to regulate IL-7 expression in myasthenia gravis.
Title: LncRNA OIP5-AS1 modulates the proliferation and apoptosis of Jurkat cells by sponging miR-181c-5p to regulate IL-7 expression in myasthenia gravis.
IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma.
Title: IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma.
IL-7 is expressed in malignant mesothelioma and has a prognostic value.
Title: IL-7 is expressed in malignant mesothelioma and has a prognostic value.
The Role of IL-7 and IL-7R in Cancer Pathophysiology and Immunotherapy.
Title: The Role of IL-7 and IL-7R in Cancer Pathophysiology and Immunotherapy.
IL-7/IL7R axis dysfunction in adults with severe community-acquired pneumonia (CAP): a cross-sectional study.
Title: IL-7/IL7R axis dysfunction in adults with severe community-acquired pneumonia (CAP): a cross-sectional study.

Submit: New GeneRIF Correction See all GeneRIFs (245)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Epidermodysplasia verruciformis, susceptibility to, 5 MedGen: C4749043 OMIM: 618309 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Clinical samples of cerebrospinal fluid from patients infected with HIV-1 subtypes B and C exhibited upregulated levels of IL7, IL10, CXCL10 (IP10), CCL2 (MCP1), and CCL3 (MIP1A)	PubMed
HIV-1 replication in resting peripheral blood CD4 T cells is rescued by IL7; IL7 rescues resting peripheral blood CD4 T cells from HIV-1-induced T cell death	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120-induced neuronal apoptosis is augmented by IL-7	PubMed
Envelope surface glycoprotein gp160, precursor	env	IL-7-treated resting CD4+ T cells produce more Env protein than untreated cells	PubMed
	env	IL-7 and IL-12 significantly augment proliferative responses to HIV-1 gp160	PubMed
Pr55(Gag)	gag	IL-7-treated resting CD4+ T cells produce more HIV-1 Gag protein than untreated cells	PubMed
Tat	tat	HIV-1 Tat inhibits IL7-induced upregulation of BCL-2 in CD4 T-cells	PubMed
	tat	HIV-1 Tat inhibits the effects of IL-7 on activation of CD8 T-cells signaling via IL-7R	PubMed
	tat	Upregulation of intracellular perforin accumulation by IL-7 in CD4 or CD8 T-cells is inhibited by HIV-1 Tat	PubMed
	tat	HIV-1 Tat-mediated degradation of IL-7R alpha-chain (CD127) from the surface of resting CD8 T cells leads to reduced IL-7 signaling and to impaired CD8 T cell proliferation and function	PubMed
	tat	HIV-1 Tat and IL-7 act synergistically to downregulate CD127 on CD8+ T cells. Downregulation of CD127 by IL-7 requires JAK activation pathway	PubMed
capsid	gag	Unactivated memory CD4+ T cells infected by HIV-1 in the presence of IL-2 and IL-15 alone or IL-6/IL-7/TNF-alpha combination, upregulate granzyme B and HIV-1 CA production	PubMed
integrase	gag-pol	IL-7 and CD95 synergistically promote survival and proliferation of HIV-1-latently infected CD4+ T-cells measured by increased levels of integrated HIV-1 DNA, suggesting that HIV-1 IN interacts with IL-7 and CD95 in latently infected CD4+ T-cells	PubMed
	gag-pol	Treatment of resting CD4+ T cells with cytokines IL-2, IL-4, IL-7, or IL15 enhances HIV-1 IN mutant D116N to generate de novo virus production	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-J04156 (e-PCR)
- UniSTS:2572

STS-J04156 (e-PCR)
- UniSTS:6936

STS-M29049 (e-PCR)
- UniSTS:82793

IL7_159 (e-PCR)
- UniSTS:277381

RH93634 (e-PCR)
- UniSTS:91536

D8S1626 (e-PCR)
- UniSTS:38353

GDB:177377 (e-PCR)
- UniSTS:154873

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables interleukin-7 receptor binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in T cell lineage commitment	IEA Inferred from Electronic Annotation more info
involved_in animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in bone resorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in homeostasis of number of cells within a tissue	IEA Inferred from Electronic Annotation more info
involved_in humoral immune response	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
involved_in organ growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of B cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of B cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of chemokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of organ growth	IEA Inferred from Electronic Annotation more info
involved_in regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000880.4 → NP_000871.1 interleukin-7 isoform 1 precursor

See identical proteins and their annotated locations for NP_000871.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK291538, BC047698, J04156

Consensus CDS

CCDS6224.1

UniProtKB/Swiss-Prot

A0N0L3, P13232, Q5FBY5, Q5FBY9

UniProtKB/TrEMBL

A8K673

Related

ENSP00000263851.4, ENST00000263851.9

Conserved Domains (1) summary

smart00127
Location:27 → 173

IL7; Interleukin-7 and interleukin-9 family
NM_001199886.2 → NP_001186815.1 interleukin-7 isoform 2 precursor

See identical proteins and their annotated locations for NP_001186815.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, which results in a shorter isoform (2) compared to isoform 1.

Source sequence(s)

AB102879, AK291538, BC047698

Consensus CDS

CCDS56541.1

UniProtKB/Swiss-Prot

P13232

UniProtKB/TrEMBL

A8K673

Related

ENSP00000427750.1, ENST00000520269.5

Conserved Domains (1) summary

cl11602
Location:27 → 129

IL7; Interleukin 7/9 family
NM_001199887.2 → NP_001186816.1 interleukin-7 isoform 3 precursor

See identical proteins and their annotated locations for NP_001186816.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1, which results in a shorter isoform (3) compared to isoform 1.

Source sequence(s)

AK291538, BC047698, CD013923

Consensus CDS

CCDS75756.1

UniProtKB/TrEMBL

A0A0A0MTG5, A8K673

Related

ENSP00000438922.2, ENST00000541183.2

Conserved Domains (1) summary

cl11602
Location:27 → 155

IL7; Interleukin 7/9 family
NM_001199888.2 → NP_001186817.1 interleukin-7 isoform 4 precursor

See identical proteins and their annotated locations for NP_001186817.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks multiple in-frame exons in the 3' coding region, compared to variant 1, which result in a shorter isoform (4) compared to isoform 1.

Source sequence(s)

AB102893, AK291538, BC047698

Consensus CDS

CCDS75755.1

UniProtKB/TrEMBL

Q5FBX5

Related

ENSP00000368408.3, ENST00000379113.6

Conserved Domains (1) summary

cl11602
Location:27 → 111

IL7; Interleukin 7/9 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

78675044..78805463 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011517523.4 → XP_011515825.1 interleukin-7 isoform X2

Conserved Domains (1) summary

cl11602
Location:27 → 138

IL7; Interleukin 7/9 family
XM_011517522.4 → XP_011515824.1 interleukin-7 isoform X1

Conserved Domains (1) summary

cl11602
Location:27 → 138

IL7; Interleukin 7/9 family
XM_047421768.1 → XP_047277724.1 interleukin-7 isoform X3
XM_047421767.1 → XP_047277723.1 interleukin-7 isoform X3
XM_047421765.1 → XP_047277721.1 interleukin-7 isoform X3
XM_047421766.1 → XP_047277722.1 interleukin-7 isoform X3