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    CXADR coxsackie virus and adenovirus receptor [ Homo sapiens (human) ]

    Gene ID: 1525, updated on 9-Jul-2016
    Official Symbol
    CXADRprovided by HGNC
    Official Full Name
    coxsackie virus and adenovirus receptorprovided by HGNC
    Primary source
    HGNC:HGNC:2559
    See related
    Ensembl:ENSG00000154639 HPRD:11804; MIM:602621; Vega:OTTHUMG00000074508
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAR; HCAR; CAR4/6
    Summary
    The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]
    Orthologs
    Location:
    21q21.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 21 NC_000021.9 (17512906..17636213)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (18885224..18965897)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene transfer RNA-Gly (GCC) 1-5 Neighboring gene ribosomal protein L39 pseudogene 40 Neighboring gene basic transcription factor 3 like 4 pseudogene 1 Neighboring gene BTG anti-proliferation factor 3 Neighboring gene uncharacterized LOC105372741 Neighboring gene C21orf91 overlapping transcript 1 Neighboring gene chromosome 21 open reading frame 91

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    connexin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    AV node cell to bundle of His cell communication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin cytoskeleton reorganization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cardiac muscle fiber development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell-cell junction organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    epithelial structure maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gamma-delta T cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    germ cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of immune response TAS
    Traceable Author Statement
    more info
     
    transepithelial transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    acrosomal vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell junction IDA
    Inferred from Direct Assay
    more info
     
    cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    filopodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    coxsackievirus and adenovirus receptor
    Names
    46 kD coxsackievirus and adenovirus receptor (CAR) protein
    CVB3-binding protein
    HCVADR
    coxsackievirus B-adenovirus receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029458.1 RefSeqGene

      Range
      5001..85674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001207063.1NP_001193992.1  coxsackievirus and adenovirus receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001193992.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, alternatively referred to as beta or CAR4/7) lacks two consecutive alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform (1).
      Source sequence(s)
      AI498294, AP000967, AY072912, CV570985
      Consensus CDS
      CCDS56205.1
      UniProtKB/Swiss-Prot
      P78310
      Related
      ENSP00000383030, OTTHUMP00000083234, ENST00000400166, OTTHUMT00000158211
      Conserved Domains (2) summary
      smart00410
      Location:29137
      IG_like; Immunoglobulin like
      cl11960
      Location:22137
      Ig; Immunoglobulin domain
    2. NM_001207064.1NP_001193993.1  coxsackievirus and adenovirus receptor isoform 3 precursor

      See identical proteins and their annotated locations for NP_001193993.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, alternatively referred to as gamma or CAR3/7) lacks three consecutive alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform (1).
      Source sequence(s)
      AI498294, AP000967, AY072911, CV570985
      Consensus CDS
      CCDS56206.1
      UniProtKB/Swiss-Prot
      P78310
      Related
      ENSP00000383029, OTTHUMP00000083235, ENST00000400165, OTTHUMT00000158212
      Conserved Domains (2) summary
      smart00410
      Location:29137
      IG_like; Immunoglobulin like
      cl11960
      Location:22137
      Ig; Immunoglobulin domain
    3. NM_001207065.1NP_001193994.1  coxsackievirus and adenovirus receptor isoform 4 precursor

      See identical proteins and their annotated locations for NP_001193994.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, alternatively referred to as delta or CAR2/7) lacks four consecutive alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform (1).
      Source sequence(s)
      AI498294, AP000967, AY072910, CV570985
      Consensus CDS
      CCDS56207.1
      UniProtKB/Swiss-Prot
      P78310
      Related
      ENSP00000348620, OTTHUMP00000208017, ENST00000356275, OTTHUMT00000340163
    4. NM_001207066.1NP_001193995.1  coxsackievirus and adenovirus receptor isoform 5 precursor

      See identical proteins and their annotated locations for NP_001193995.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, alternatively referred to as CAREx8) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AP000967, CV570985
      Consensus CDS
      CCDS56204.1
      UniProtKB/Swiss-Prot
      P78310
      Related
      ENSP00000383033, OTTHUMP00000083233, ENST00000400169, OTTHUMT00000158210
      Conserved Domains (4) summary
      cd00096
      Location:159223
      Ig; Immunoglobulin domain
      smart00408
      Location:154219
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:29137
      IG_like; Immunoglobulin like
      cl11960
      Location:22137
      Ig; Immunoglobulin domain
    5. NM_001338.4NP_001329.1  coxsackievirus and adenovirus receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_001329.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, alternatively referred to as alpha or CAREx7) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI498294, AK313526, AP000967, CV570985
      Consensus CDS
      CCDS33519.1
      UniProtKB/Swiss-Prot
      P78310
      Related
      ENSP00000284878, OTTHUMP00000083232, ENST00000284878, OTTHUMT00000158209
      Conserved Domains (4) summary
      cd00096
      Location:159223
      Ig; Immunoglobulin domain
      smart00408
      Location:154219
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:29137
      IG_like; Immunoglobulin like
      cl11960
      Location:22137
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p7 Primary Assembly

      Range
      17512906..17636213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529478.2XP_011527780.1  

      Conserved Domains (2) summary
      smart00410
      Location:29137
      IG_like; Immunoglobulin like
      cl11960
      Location:22137
      Ig; Immunoglobulin domain
    2. XM_011529476.2XP_011527778.1  

      Conserved Domains (4) summary
      cd00096
      Location:159223
      Ig; Immunoglobulin domain
      smart00408
      Location:154219
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:29137
      IG_like; Immunoglobulin like
      cl11960
      Location:22137
      Ig; Immunoglobulin domain
    3. XM_011529479.1XP_011527781.1  

      See identical proteins and their annotated locations for XP_011527781.1

      UniProtKB/Swiss-Prot
      P78310
      Conserved Domains (2) summary
      smart00410
      Location:29137
      IG_like; Immunoglobulin like
      cl11960
      Location:22137
      Ig; Immunoglobulin domain
    4. XM_011529477.2XP_011527779.1  

      Conserved Domains (2) summary
      smart00410
      Location:29137
      IG_like; Immunoglobulin like
      cl11960
      Location:22137
      Ig; Immunoglobulin domain

    RNA

    1. XR_001754814.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018932.2 Alternate CHM1_1.1

      Range
      18445887..18526468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)