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Trpc4 transient receptor potential cation channel, subfamily C, member 4 [ Mus musculus (house mouse) ]

Gene ID: 22066, updated on 24-Feb-2015
Official Symbol
Trpc4provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily C, member 4provided by MGI
Primary source
MGI:MGI:109525
See related
Ensembl:ENSMUSG00000027748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CCE1; Trp4; Trrp4; STRPC4
Orthologs
See Trpc4 in MapViewer
Location:
3 25.43 cM; 3 D
Exon count:
13
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 3 NC_000069.6 (54156057..54318471)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A pseudogene Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene, 31095 Neighboring gene periostin, osteoblast specific factor

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
cadherin binding ISO
Inferred from Sequence Orthology
more info
 
calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
inositol 1,4,5 trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
store-operated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
store-operated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
calcium ion import ISO
Inferred from Sequence Orthology
more info
 
calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
cytosolic calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
gamma-aminobutyric acid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transport IEA
Inferred from Electronic Annotation
more info
 
manganese ion transport IBA
Inferred from Biological aspect of Ancestor
more info
 
oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
cortical cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein complex IPI
Inferred from Physical Interaction
more info
PubMed 
Preferred Names
short transient receptor potential channel 4
Names
short transient receptor potential channel 4
capacitative calcium entry channel Trp4
putative capacitative calcium entry channel
receptor-activated cation channel TRP4
transient receptor protein 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253682.1NP_001240611.1  short transient receptor potential channel 4 isoform 2

    See proteins identical to NP_001240611.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame coding segment in the last exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC117594, AK080670, CO043592
    UniProtKB/TrEMBL
    Q8BNT2
    UniProtKB/Swiss-Prot
    Q9QUQ5
    Conserved Domains (3) summary
    TIGR00870
    Location:17749
    trp; transient-receptor-potential calcium channel protein
    cd00204
    Location:64168
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08344
    Location:176238
    TRP_2; Transient receptor ion channel II
  2. NM_001253683.1NP_001240612.1  short transient receptor potential channel 4 isoform 3

    See proteins identical to NP_001240612.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC117594, AK080670, AK084139
    UniProtKB/TrEMBL
    Q8BNB6
    UniProtKB/TrEMBL
    Q8BNT2
    Conserved Domains (3) summary
    cd00204
    Location:64168
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08344
    Location:176238
    TRP_2; Transient receptor ion channel II
    pfam12796
    Location:100168
    Ank_2; Ankyrin repeats (3 copies)
  3. NM_016984.3NP_058680.1  short transient receptor potential channel 4 isoform 1

    See proteins identical to NP_058680.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC117594, AK080670, CO043592
    Consensus CDS
    CCDS17350.1
    UniProtKB/TrEMBL
    Q0VB97
    UniProtKB/TrEMBL
    Q8BNT2
    UniProtKB/Swiss-Prot
    Q9QUQ5
    Related
    ENSMUSP00000029311, ENSMUST00000029311
    Conserved Domains (3) summary
    TIGR00870
    Location:17749
    trp; transient-receptor-potential calcium channel protein
    cd00204
    Location:64168
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08344
    Location:176238
    TRP_2; Transient receptor ion channel II

RNA

  1. NR_046161.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of an exon compared to variant 1, that causes a frameshift. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK080670, BC060160, CO043592

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p3 C57BL/6J

    Range
    54156057..54318471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501296.2XP_006501359.1  

    See proteins identical to XP_006501359.1

    UniProtKB/TrEMBL
    Q0VB97
    UniProtKB/Swiss-Prot
    Q9QUQ5
    Conserved Domains (3) summary
    TIGR00870
    Location:17749
    trp; transient-receptor-potential calcium channel protein
    cd00204
    Location:64168
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08344
    Location:176238
    TRP_2; Transient receptor ion channel II
  2. XM_006501297.2XP_006501360.1  

    See proteins identical to XP_006501360.1

    Conserved Domains (1) summary
    TIGR00870
    Location:1329
    trp; transient-receptor-potential calcium channel protein
  3. XM_006501298.1XP_006501361.1  

    See proteins identical to XP_006501361.1

    Conserved Domains (1) summary
    TIGR00870
    Location:1329
    trp; transient-receptor-potential calcium channel protein

Alternate Mm_Celera

Genomic

  1. AC_000025.1 Alternate Mm_Celera

    Range
    53878313..54040525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)