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Vhl von Hippel-Lindau tumor suppressor [ Mus musculus (house mouse) ]

Gene ID: 22346, updated on 6-Jul-2014
Official Symbol
Vhlprovided by MGI
Official Full Name
von Hippel-Lindau tumor suppressorprovided by MGI
Primary source
MGI:103223
See related
Ensembl:ENSMUSG00000033933; Vega:OTTMUSG00000024147
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vhlh
Location:
6 E3; 6 52.81 cM
Exon count :
3
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 6 NC_000072.6 (113624021..113631633)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene Fanconi anemia, complementation group D2 Neighboring gene Fancd2 opposite strand Neighboring gene BRICK1, SCAR/WAVE actin-nucleating complex subunit Neighboring gene interleukin-1 receptor-associated kinase 2 Neighboring gene TatD DNase domain containing 2 Neighboring gene microRNA mir-7042

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of thymocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of catecholamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of thymocyte apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
VCB complex ISO
Inferred from Sequence Orthology
more info
 
cilium IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
von Hippel-Lindau disease tumor suppressor
Names
von Hippel-Lindau disease tumor suppressor
pVHL
von Hippel-Lindau syndrome homolog
von Hippel-Lindau syndrome protein homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009507.3NP_033533.1  von Hippel-Lindau disease tumor suppressor

    See proteins identical to NP_033533.1

    Status: PROVISIONAL

    Source sequence(s)
    AC153987
    Consensus CDS
    CCDS20429.1
    UniProtKB/Swiss-Prot
    P40338
    UniProtKB/TrEMBL
    Q3TTE7
    Related
    ENSMUSP00000039418, OTTMUSP00000028703, ENSMUST00000035673, OTTMUST00000059073
    Conserved Domains (1) summary
    cd05468
    Location:30169
    Blast Score: 402
    pVHL; von Hippel-Landau (pVHL) tumor suppressor protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000072.6 

    Range
    113624021..113631633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000028.1 

    Range
    115450882..115458459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Supplemental Content

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