Display Settings:

Format

Send to:

Choose Destination

Tnfsf13b tumor necrosis factor (ligand) superfamily, member 13b [ Mus musculus (house mouse) ]

Gene ID: 24099, updated on 19-Jul-2014
Official Symbol
Tnfsf13bprovided by MGI
Official Full Name
tumor necrosis factor (ligand) superfamily, member 13bprovided by MGI
Primary source
MGI:1344376
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BAFF; BLyS; TALL1; THANK; zTNF4; TALL-1; TNFSF20; D8Ertd387e
See Tnfsf13b in Epigenomics, MapViewer
Location:
8 A1.1; 8 4.55 cM
Exon count:
10
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 8 NC_000074.6 (10006193..10119678)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 13 Neighboring gene ligase IV, DNA, ATP-dependent Neighboring gene myosin XVI Neighboring gene uncharacterized LOC102634842

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
    Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
  • Intestinal immune network for IgA production, conserved biosystem (from KEGG)
    Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
  • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
    NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
    Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Rheumatoid arthritis, conserved biosystem (from KEGG)
    Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC124060, MGC124061

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell costimulation IDA
Inferred from Direct Assay
more info
PubMed 
B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell costimulation IDA
Inferred from Direct Assay
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
immunoglobulin secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of B cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of germinal center formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell IGI
Inferred from Genetic Interaction
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tumor necrosis factor ligand superfamily member 13B
Names
tumor necrosis factor ligand superfamily member 13B
B-cell-activating factor
b cell-activating factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033622.1NP_296371.1  tumor necrosis factor ligand superfamily member 13B

    See proteins identical to NP_296371.1

    Status: PROVISIONAL

    Source sequence(s)
    AF119383
    Consensus CDS
    CCDS22094.1
    UniProtKB/TrEMBL
    Q3KP92
    UniProtKB/Swiss-Prot
    Q9WU72
    Conserved Domains (2) summary
    cd00184
    Location:170306
    Blast Score: 218
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    cl11564
    Location:81155
    Blast Score: 87
    GcrA; GcrA cell cycle regulator

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000074.6 

    Range
    10006193..10119678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508776.1XP_006508839.1  

    Conserved Domains (1) summary
    cl11564
    Location:86155
    Blast Score: 82
    GcrA; GcrA cell cycle regulator
  2. XM_006508777.1XP_006508840.1  

    Conserved Domains (1) summary
    cl11564
    Location:86155
    Blast Score: 82
    GcrA; GcrA cell cycle regulator
  3. XM_006508774.1XP_006508837.1  

    See proteins identical to XP_006508837.1

    UniProtKB/Swiss-Prot
    Q9WU72
    Conserved Domains (2) summary
    cd00184
    Location:164287
    Blast Score: 214
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    cl11564
    Location:81155
    Blast Score: 86
    GcrA; GcrA cell cycle regulator
  4. XM_006508775.1XP_006508838.1  

    Conserved Domains (1) summary
    cd00184
    Location:139275
    Blast Score: 218
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

RNA

  1. XR_378661.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000030.1 

    Range
    10182059..10211354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)