Display Settings:

Format

Send to:

Choose Destination

NDRG3 NDRG family member 3 [ Homo sapiens (human) ]

Gene ID: 57446, updated on 26-Aug-2014
Official Symbol
NDRG3provided by HGNC
Official Full Name
NDRG family member 3provided by HGNC
Primary source
HGNC:14462
Locus tag
RP3-460J8.1
See related
Ensembl:ENSG00000101079; HPRD:12007; MIM:605273; Vega:OTTHUMG00000032398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
See NDRG3 in Epigenomics, MapViewer
Location:
20q11.21-q11.23
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 20 NC_000020.11 (36651766..36746138, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (35280169..35374541, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene TGIF2-C20orf24 readthrough Neighboring gene chromosome 20 open reading frame 24 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 2 Neighboring gene Src-like-adaptor 2 Neighboring gene DSN1, MIS12 kinetochore complex component Neighboring gene suppressor of glucose, autophagy associated 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of NDRG family member 3 (NDRG3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ13556

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
spermatogenesis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
protein NDRG3
Names
protein NDRG3
N-myc downstream-regulated gene 3 protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022477.3NP_071922.2  protein NDRG3 isoform b

    See proteins identical to NP_071922.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in an isoform (b) that is shorter compared to isoform a.
    Source sequence(s)
    AA903471, AF308609, AK023618, AL132768, BC136489, DA788570
    Consensus CDS
    CCDS13284.1
    UniProtKB/Swiss-Prot
    Q9UGV2
    Related
    ENSP00000352703, OTTHUMP00000178597, ENST00000359675, OTTHUMT00000276175
    Conserved Domains (2) summary
    COG0596
    Location:26300
    Blast Score: 164
    MhpC; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]
    pfam03096
    Location:20305
    Blast Score: 1217
    Ndr; Ndr family
  2. NM_032013.3NP_114402.1  protein NDRG3 isoform a

    See proteins identical to NP_114402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA903471, AB044943, AF308609, AL132768, DA788570
    Consensus CDS
    CCDS13285.1
    UniProtKB/Swiss-Prot
    Q9UGV2
    Related
    ENSP00000345292, OTTHUMP00000030882, ENST00000349004, OTTHUMT00000079053
    Conserved Domains (2) summary
    COG0596
    Location:38312
    Blast Score: 164
    MhpC; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]
    pfam03096
    Location:32317
    Blast Score: 1218
    Ndr; Ndr family

RNA

  1. NR_038370.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA903471, AF308609, AK295420, AL132768, BC136489, DA788570

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11 

    Range
    36651766..36746138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723837.1XP_006723900.1  

    See proteins identical to XP_006723900.1

    UniProtKB/TrEMBL
    Q5TH30
    Related
    ENSP00000362909, OTTHUMP00000030884, ENST00000373803, OTTHUMT00000079055
    Conserved Domains (2) summary
    COG0596
    Location:38312
    Blast Score: 164
    MhpC; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]
    pfam03096
    Location:32317
    Blast Score: 1216
    Ndr; Ndr family
  2. XM_006723838.1XP_006723901.1  

    Conserved Domains (2) summary
    COG0596
    Location:29303
    Blast Score: 164
    MhpC; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]
    pfam03096
    Location:23308
    Blast Score: 1214
    Ndr; Ndr family

Alternate HuRef

Genomic

  1. AC_000152.1 

    Range
    32016200..32111174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 

    Range
    35182002..35276298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)