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    Il17a interleukin 17A [ Mus musculus (house mouse) ]

    Gene ID: 16171, updated on 31-Jan-2016
    Official Symbol
    Il17aprovided by MGI
    Official Full Name
    interleukin 17Aprovided by MGI
    Primary source
    MGI:MGI:107364
    See related
    Ensembl:ENSMUSG00000025929; Vega:OTTMUSG00000033825
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il17; Ctla8; IL-17; Ctla-8; IL-17A
    Summary
    This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]
    Orthologs
    See Il17a in Epigenomics, MapViewer
    Location:
    1; 1 A
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (20730905..20734496)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (20720986..20724577)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene microRNA 206 Neighboring gene microRNA 133b Neighboring gene interleukin 17F Neighboring gene minichromosome maintenance deficient 3 (S. cerevisiae)

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
      Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
      Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
      Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    interleukin-17A
    Names
    cytotoxic T-lymphocyte-associated antigen 8

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010552.3NP_034682.1  interleukin-17A precursor

      See identical proteins and their annotated locations for NP_034682.1

      Status: REVIEWED

      Source sequence(s)
      AK040420
      Consensus CDS
      CCDS14842.1
      UniProtKB/TrEMBL
      Q544E6
      UniProtKB/Swiss-Prot
      Q62386
      Related
      ENSMUSP00000027061, OTTMUSP00000046003, ENSMUST00000027061, OTTMUST00000085210
      Conserved Domains (1) summary
      pfam06083
      Location:71150
      IL17; Interleukin-17

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

      Range
      20730905..20734496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000023.1 Alternate Mm_Celera

      Range
      20604456..20608046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)