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PRNP prion protein [ Bos taurus (cattle) ]

Gene ID: 281427, updated on 3-May-2015
Gene symbol
PRNP
Gene description
prion protein
See related
BGD:BT10271; Ensembl:ENSBTAG00000027937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
PrP; AltPrP
Orthologs
See PRNP in MapViewer
Location:
13q17
Exon count:
3
Annotation release Status Assembly Chr Location
104 current Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 13 AC_000170.1 (47400392..47418507)

Chromosome 13 - AC_000170.1Genomic Context describing neighboring genes Neighboring gene DIP2 disco-interacting protein 2 homolog C (Drosophila) Neighboring gene microRNA mir-2285m-2 Neighboring gene zinc finger, MYND-type containing 11 Neighboring gene prion protein 2 (dublet) Neighboring gene Ras association (RalGDS/AF-6) domain family member 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC140197

Gene Ontology Provided by GOA

Function Evidence Code Pubs
copper ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to copper ion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of activated T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interferon-gamma production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-17 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-2 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of protein localization IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
alternative prion protein; major prion protein
Names
major prion protein
major scrapie-associated fibril protein 1
prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)
prion protein PrP
prion protein precursor PrP
prion protein variant a
prion protein variant b

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271625.1NP_001258554.1  alternative prion protein AltPrp

    See identical proteins and their annotated locations for NP_001258554.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes a shorter protein from an overlapping reading frame, compared to variant 1. Alternative prion protein (AltPrp) has no similarity to the other protein encoded by this gene and localizes to the outer mitochondrial membrane.
    Source sequence(s)
    AAFC03011817, AAFC03011819
    UniProtKB/Swiss-Prot
    F7VJQ2
  2. NM_001271626.1NP_001258555.1  major prion protein preproprotein

    See identical proteins and their annotated locations for NP_001258555.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AAFC03011817, AAFC03011819
    UniProtKB/TrEMBL
    A6YK35
    UniProtKB/Swiss-Prot
    P10279
    Conserved Domains (2) summary
    smart00157
    Location:25251
    PRP; Major prion protein
    pfam11587
    Location:130
    Prion_bPrPp; Major prion protein bPrPp - N terminal
  3. NM_181015.2NP_851358.2  major prion protein precursor

    See identical proteins and their annotated locations for NP_851358.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AAFC03011817, AAFC03011819
    UniProtKB/TrEMBL
    A6YK35
    UniProtKB/Swiss-Prot
    P10279
    Related
    ENSBTAP00000043233, ENSBTAT00000040292
    Conserved Domains (2) summary
    smart00157
    Location:25251
    PRP; Major prion protein
    pfam11587
    Location:130
    Prion_bPrPp; Major prion protein bPrPp - N terminal

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Bos_taurus_UMD_3.1.1 Primary Assembly

Genomic

  1. AC_000170.1 Reference Bos_taurus_UMD_3.1.1 Primary Assembly

    Range
    47400392..47418507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Btau_4.6.1

Genomic

  1. NC_007311.5 Alternate Btau_4.6.1

    Range
    47034751..47054674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)