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    Irf8 interferon regulatory factor 8 [ Mus musculus (house mouse) ]

    Gene ID: 15900, updated on 25-Aug-2016
    Official Symbol
    Irf8provided by MGI
    Official Full Name
    interferon regulatory factor 8provided by MGI
    Primary source
    MGI:MGI:96395
    See related
    Ensembl:ENSMUSG00000041515 Vega:OTTMUSG00000033858
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Myls; ICSBP; IRF-8; Icsbp1; AI893568
    Summary
    The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
    Orthologs
    Location:
    8 E1; 8 70.05 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (120736358..120756694)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (123260276..123280594)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39265 Neighboring gene mitochondrial ribosomal protein L30 pseudogene Neighboring gene predicted gene, 39266 Neighboring gene predicted gene, 33199

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
      Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    regulatory region DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, sequence-specific DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    interferon regulatory factor 8
    Names
    interferon consensus sequence binding protein 1
    interferon consensus sequence-binding protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301811.1NP_001288740.1  interferon regulatory factor 8

      See identical proteins and their annotated locations for NP_001288740.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK018533, AK137450, BF662476
      Consensus CDS
      CCDS22721.1
      UniProtKB/Swiss-Prot
      P23611
      UniProtKB/TrEMBL
      Q544J7
      Related
      ENSMUSP00000125029, OTTMUSP00000046088, ENSMUST00000162001, OTTMUST00000085323
      Conserved Domains (2) summary
      cd00103
      Location:7114
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
      pfam10401
      Location:202379
      IRF-3; Interferon-regulatory factor 3
    2. NM_008320.4NP_032346.1  interferon regulatory factor 8

      See identical proteins and their annotated locations for NP_032346.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK018533, AK150370, AK151324, BF662476
      Consensus CDS
      CCDS22721.1
      UniProtKB/Swiss-Prot
      P23611
      UniProtKB/TrEMBL
      Q3UCV9, Q544J7
      Related
      ENSMUSP00000040245, OTTMUSP00000046087, ENSMUST00000047737, OTTMUST00000085321
      Conserved Domains (2) summary
      cd00103
      Location:7114
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
      pfam10401
      Location:202379
      IRF-3; Interferon-regulatory factor 3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      120736358..120756694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)