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CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) [ Homo sapiens (human) ]

Gene ID: 1026, updated on 7-Dec-2014
Official Symbol
CDKN1Aprovided by HGNC
Official Full Name
cyclin-dependent kinase inhibitor 1A (p21, Cip1)provided by HGNC
Primary source
HGNC:HGNC:1784
See related
Ensembl:ENSG00000124762; HPRD:00298; MIM:116899; Vega:OTTHUMG00000014603
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1
Summary
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010]
See CDKN1A in Epigenomics, MapViewer
Location:
6p21.2
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (36676460..36687339)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36644237..36655116)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene microRNA 3925 Neighboring gene promoter of CDKN1A antisense DNA damage activated RNA Neighboring gene leucine aminopeptidase 3 pseudogene 2 Neighboring gene RAB44, member RAS oncogene family Neighboring gene G protein-coupled receptor 166 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.
NHGRI GWA Catalog
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
NHGRI GWA Catalog
Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk.
NHGRI GWA Catalog
Several common variants modulate heart rate, PR interval and QRS duration.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of cyclin-dependent kinase inhibitor 1A (CDKN1A; p21; Cip1) in human B cells PubMed
env HIV-1 gp120 induces NF-kappaB activation and increases p21(cip1/waf1) and p27(kip1) protein levels in human mesangial cells PubMed
Tat tat Treatment with HIV-Tat and morphine activates extracellular signal-regulated kinase-1/2 (ERK1/2), upregulates p53 and p21 levels, and downregulates cyclin D1 and Akt levels in human fetal brain-derived neural precursor cells PubMed
tat HIV-1 Tat inhibits SIRT1 and increases acetylation of p53, which leads to activation of p21 and BAX in HeLa-CD4+ cells PubMed
tat A p53 fusion protein with the HIV-1 Tat basic domain at its N terminus activates the expression of p21and downregulates the levels of caspase-3 and Bcl-2 PubMed
Vif vif HIV-1 Vif upregulates the expression of cyclin-dependent kinase inhibitor 1A (CDKN1A, p21, Cip1) in Vif-expression T cells PubMed
Vpr vpr Activation of p21/Waf1/Cip1 by HIV-1 Vpr appears to be dependent upon p53 PubMed
vpr COUP-TF-interacting protein 2 (CTIP2) abolishes Vpr-mediated stimulation of p21 by cooperating with SUV39H1 and HDAC1/HDAC2 to silence the p21 gene transcription PubMed
vpr Results from GST pull-down assays show the association of Vpr with p53 in extracts containing Sp1, suggesting the physical interaction of Vpr with Sp1 and p53 could modulate transcriptional activity of p21 PubMed
vpr HIV-1 Vpr activates promoter activity of p21/Cip1/Waf1 through the GC-rich region located between nucleotides -84 and -74 in a manner that requires cooperativity of Sp1, which binds to the DNA sequence spanning -84 to -74 PubMed
vpr HIV-1 Vpr activates the expression and transcription of the cyclin-dependent kinase inhibitor p21/Waf1/Cip1, an inhibitor of the G1 and G2/M phase transitions in T lymphoid and myeloid cells PubMed
integrase gag-pol Cyclin-dependent kinase inhibitor (CKI) p21 (Waf1/Cip1/Sdi1) blocks viral infection by complexing with HIV-1 integrase and aborting chromosomal integration in hematopoietic stem cells PubMed

Go to the HIV-1, Human Interaction Database

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    SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystemDuring G1, the activity of cyclin-dependent kinases (CDKs) is kept in check by the CDK inhibitors (CKIs) p27 and p21, thereby preventing premature entry into S phase (see Guardavaccaro and Pagano, 20...
  • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
    Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
  • Senescence-Associated Secretory Phenotype (SASP), organism-specific biosystem (from REACTOME)
    Senescence-Associated Secretory Phenotype (SASP), organism-specific biosystemThe culture medium of senescent cells in enriched in secreted proteins when compared with the culture medium of quiescent i.e. presenescent cells and these secreted proteins constitute the so-called ...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling Pathways in Glioblastoma, organism-specific biosystem (from WikiPathways)
    Signaling Pathways in Glioblastoma, organism-specific biosystemThe most frequently altered genes in glioblastoma. This pathway originally accompanied the 2008 Nature publication on the comprehensive genomic characterization of human glioblastoma genes and core p...
  • Signaling by EGFR, organism-specific biosystem (from REACTOME)
    Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
  • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
    Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in parallel with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR ca...
  • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
    Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
  • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
    Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
  • Signaling by FGFR, organism-specific biosystem (from REACTOME)
    Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
    Signaling by FGFR in disease, organism-specific biosystemThe pathway 'Signaling by FGFR in disease' shows 'Signaling by FGFR mutants' in parallel with the wild-type pathway 'Signaling by FGFR', allowing users to compare disease and normal events. FGFR mut...
  • Signaling by PDGF, organism-specific biosystem (from REACTOME)
    Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
  • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
    Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
  • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
    Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
  • Signaling events mediated by HDAC Class III, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class III, organism-specific biosystem
    Signaling events mediated by HDAC Class III
  • Signaling events mediated by PRL, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by PRL, organism-specific biosystem
    Signaling events mediated by PRL
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
    Switching of origins to a post-replicative state, organism-specific biosystem
    Switching of origins to a post-replicative state
  • Synthesis of DNA, organism-specific biosystem (from REACTOME)
    Synthesis of DNA, organism-specific biosystemThe actual synthesis of DNA occurs in the S phase of the cell cycle. This includes the initiation of DNA replication, when the first nucleotide of the new strand is laid down during the synthesis of ...
  • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
  • TP53 network, organism-specific biosystem (from WikiPathways)
    TP53 network, organism-specific biosystemP53 is not a lonely genome guardian, it operates with the assistance of p73 and p63 within a complex network including distinct but complementary pathways. This protein family presents a high le...
  • Transcriptional activation of cell cycle inhibitor p21, organism-specific biosystem (from REACTOME)
    Transcriptional activation of cell cycle inhibitor p21, organism-specific biosystemBoth p53-independent and p53-dependent mechanisms of induction of p21 mRNA have been demonstrated. p21 is transcriptionally activated by p53 after DNA damage (el-Deiry et al., 1993).
  • Transcriptional activation of p53 responsive genes, organism-specific biosystem (from REACTOME)
    Transcriptional activation of p53 responsive genes, organism-specific biosystemp53 causes G1 arrest by inducing the expression of a cell cycle inhibitor, p21 (El-Deiry et al, 1993; Harper et al, 1993; Xiong et al, 1993). P21 binds and inactivates Cyclin-Cdk complexes that medi...
  • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
    Transcriptional misregulation in cancer, organism-specific biosystem
    Transcriptional misregulation in cancer
  • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
    Transcriptional misregulation in cancer, conserved biosystem
    Transcriptional misregulation in cancer
  • Validated targets of C-MYC transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
    Validated targets of C-MYC transcriptional repression, organism-specific biosystem
    Validated targets of C-MYC transcriptional repression
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • miRNAs involved in DDR, organism-specific biosystem (from WikiPathways)
    miRNAs involved in DDR, organism-specific biosystemMicroRNA clusters involved in de DNA damage response. Genes they regulated and genes that regulate them. All genes presented in this pathway can also be found in the pathway "DNA damage response(Homo...
  • p53 signaling pathway, organism-specific biosystem (from KEGG)
    p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53 signaling pathway, conserved biosystem (from KEGG)
    p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53-Dependent G1 DNA Damage Response, organism-specific biosystem (from REACTOME)
    p53-Dependent G1 DNA Damage Response, organism-specific biosystemMost of the damage-induced modifications of p53 are dependent on the ATM kinase. The first link between ATM and p53 was predicted based on the earlier studies that showed that AT cells exhibit a redu...
  • p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystem (from REACTOME)
    p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystemThe arrest at G1/S checkpoint is mediated by the action of a widely known tumor suppressor protein, p53. Loss of p53 functions, as a result of mutations in cancer prevent the G1/S checkpoint (Kuerbi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cyclin binding IEA
Inferred from Electronic Annotation
more info
 
cyclin-dependent protein kinase activating kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
cyclin-dependent protein serine/threonine kinase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Ras protein signal transduction IEP
Inferred from Expression Pattern
more info
PubMed 
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to extracellular stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to heat IEA
Inferred from Electronic Annotation
more info
 
cellular response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
intestinal epithelial cell maturation IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
 
mitotic cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
negative regulation of G1/S transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
neurotrophin TRK receptor signaling pathway TAS
Traceable Author Statement
more info
 
organ regeneration IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
 
positive regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of programmed cell death IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
regulation of protein import into nucleus, translocation IEA
Inferred from Electronic Annotation
more info
 
response to UV IEA
Inferred from Electronic Annotation
more info
 
response to X-ray IEA
Inferred from Electronic Annotation
more info
 
response to arsenic-containing substance IEA
Inferred from Electronic Annotation
more info
 
response to corticosterone IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to hyperoxia IEA
Inferred from Electronic Annotation
more info
 
response to organonitrogen compound IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
stress-induced premature senescence TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
PCNA-p21 complex IDA
Inferred from Direct Assay
more info
PubMed 
cyclin-dependent protein kinase holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cyclin-dependent kinase inhibitor 1
Names
cyclin-dependent kinase inhibitor 1
DNA synthesis inhibitor
CDK-interacting protein 1
CDK-interaction protein 1
wild-type p53-activated fragment 1
melanoma differentiation associated protein 6

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009364.1 

    Range
    2779..13658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000389.4NP_000380.1  cyclin-dependent kinase inhibitor 1 isoform 1

    See proteins identical to NP_000380.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. The resulting isoform (1) has a shorter N-terminus, compared to isoform 2. Variants 1, 2, 4 and 5 encode the same isoform 1.
    Source sequence(s)
    BC000275, BC000312, BQ941282, DA582789
    Consensus CDS
    CCDS4824.1
    UniProtKB/TrEMBL
    A0A024RCX5
    UniProtKB/Swiss-Prot
    P38936
    Related
    ENSP00000244741, OTTHUMP00000016297, ENST00000244741, OTTHUMT00000040354
    Conserved Domains (1) summary
    pfam02234
    Location:1969
    CDI; Cyclin-dependent kinase inhibitor
  2. NM_001220777.1NP_001207706.1  cyclin-dependent kinase inhibitor 1 isoform 1

    See proteins identical to NP_001207706.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. The resulting isoform (1) has a shorter N-terminus, compared to isoform 2. Variants 1, 2, 4 and 5 encode the same isoform 1.
    Source sequence(s)
    AA534613, BC000312, DA702185
    Consensus CDS
    CCDS4824.1
    UniProtKB/TrEMBL
    A0A024RCX5
    UniProtKB/Swiss-Prot
    P38936
    Related
    ENSP00000482768, ENST00000615513
    Conserved Domains (1) summary
    pfam02234
    Location:1969
    CDI; Cyclin-dependent kinase inhibitor
  3. NM_001220778.1NP_001207707.1  cyclin-dependent kinase inhibitor 1 isoform 1

    See proteins identical to NP_001207707.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. The resulting isoform (1) has a shorter N-terminus, compared to isoform 2. Variants 1, 2, 4 and 5 encode the same isoform 1.
    Source sequence(s)
    AA534613, BC000312, DA552678
    Consensus CDS
    CCDS4824.1
    UniProtKB/TrEMBL
    A0A024RCX5
    UniProtKB/Swiss-Prot
    P38936
    Related
    ENSP00000384849, ENST00000405375
    Conserved Domains (1) summary
    pfam02234
    Location:1969
    CDI; Cyclin-dependent kinase inhibitor
  4. NM_001291549.1NP_001278478.1  cyclin-dependent kinase inhibitor 1 isoform 2

    See proteins identical to NP_001278478.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longer isoform (2).
    Source sequence(s)
    AI973138, BC000275, BU193165
    UniProtKB/Swiss-Prot
    P38936
    Conserved Domains (1) summary
    pfam02234
    Location:53103
    CDI; Cyclin-dependent kinase inhibitor
  5. NM_078467.2NP_510867.1  cyclin-dependent kinase inhibitor 1 isoform 1

    See proteins identical to NP_510867.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. The resulting isoform (1) has a shorter N-terminus, compared to isoform 2. Variants 1, 2, 4 and 5 encode the same isoform 1.
    Source sequence(s)
    BC000312, BQ941282, BU154329
    Consensus CDS
    CCDS4824.1
    UniProtKB/TrEMBL
    A0A024RCX5
    UniProtKB/Swiss-Prot
    P38936
    Related
    ENSP00000409259, ENST00000448526
    Conserved Domains (1) summary
    pfam02234
    Location:1969
    CDI; Cyclin-dependent kinase inhibitor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    36676460..36687339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    36645994..36657029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    36362600..36373330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)