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gbpC DEP domain-containing protein [ Dictyostelium discoideum AX4 ]

Gene ID: 8627976, updated on 8-Jul-2014
Gene symbol
gbpC
Gene description
DEP domain-containing protein
Primary source
dictyBase:DDB_G0291079
Locus tag
DDB_G0291079
Gene type
protein coding
RNA name
RasGEF domain-containing protein
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium
Old locus tag
DDBDRAFT_0189229; DDBDRAFT_0191359; DDB_0189229; DDB_0191359
Location:
chromosome: 5
Exon count :
3
Sequence:
Chromosome: 5; NC_007091.3 (4959991..4968054)

Chromosome 5 - NC_007091.3Genomic Context describing neighboring genes Neighboring gene RhoGEF domain-containing protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTP binding IDA
Inferred from Direct Assay
more info
 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
Ras guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
cGMP binding IDA
Inferred from Direct Assay
more info
PubMed 
cGMP binding IEA
Inferred from Electronic Annotation
more info
 
cGMP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding IDA
Inferred from Direct Assay
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cGMP-mediated signaling IDA
Inferred from Direct Assay
more info
 
cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Ras GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cellular component movement TAS
Traceable Author Statement
more info
PubMed 
positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with cell cortex IDA
Inferred from Direct Assay
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with plasma membrane IMP
Inferred from Mutant Phenotype
more info
 
Names
DEP domain-containing protein
GRAM domain-containing protein
ROCO family protein kinase
RasGEF domain-containing protein
cyclic GMP-binding protein
leucine-rich repeat-containing protein
protein kinase, TKL group
tyrosine kinase-like protein
XP_635392.1
  • Similar to LRR

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007091.3 

    Range
    4959991..4968054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_630300.1XP_635392.1  RasGEF domain-containing protein [Dictyostelium discoideum AX4]

    See proteins identical to XP_635392.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q8MVR1
    Conserved Domains (13) summary
    cd06224
    Location:14221495
    Blast Score: 146
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00219
    Location:8781159
    Blast Score: 521
    TyrKc; Tyrosine kinase, catalytic domain
    COG0664
    Location:20052141
    Blast Score: 157
    Crp; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    COG1100
    Location:331539
    Blast Score: 152
    COG1100; GTPase SAR1 and related small G proteins [General function prediction only]
    cd00038
    Location:24932607
    Blast Score: 174
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00116
    Location:180276
    Blast Score: 98
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd04371
    Location:16401702
    Blast Score: 117
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
    pfam00617
    Location:17051923
    Blast Score: 472
    RasGEF; RasGEF domain
    pfam12799
    Location:264298
    Blast Score: 89
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:242298
    Blast Score: 123
    LRR_8; Leucine rich repeat
    cl09925
    Location:8821159
    Blast Score: 485
    PKc_like; Protein Kinases, catalytic domain
    cl17170
    Location:329508
    Blast Score: 319
    Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
    cl17171
    Location:23632407
    Blast Score: 191
    PH-like; Pleckstrin homology-like domain

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