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ZYX zyxin [ Homo sapiens (human) ]

Gene ID: 7791, updated on 11-Sep-2014
Official Symbol
ZYXprovided by HGNC
Official Full Name
zyxinprovided by HGNC
Primary source
HGNC:HGNC:13200
See related
Ensembl:ENSG00000159840; HPRD:03592; MIM:602002; Vega:OTTHUMG00000023822
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESP-2; HED-2
Summary
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]
Location:
7q32
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 7 NC_000007.14 (143381245..143391111)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143078338..143088204)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928397 Neighboring gene family with sequence similarity 131, member B Neighboring gene uncharacterized LOC100507507 Neighboring gene microRNA 6892 Neighboring gene EPH receptor A1 Neighboring gene EPHA1 antisense RNA 1 Neighboring gene taste receptor, type 2, member 62, pseudogene Neighboring gene taste receptor, type 2, member 60

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of zyxin (ZYX) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef Yeast two hybrid assay identifies the HIV-1 Nef-interacting protein zyxin. HIV-1 Nef co-localizes with zyxin in the cortical regions of human podocyte PubMed

Go to the HIV-1, Human Interaction Database

  • E-cadherin signaling in keratinocytes, organism-specific biosystem (from Pathway Interaction Database)
    E-cadherin signaling in keratinocytes, organism-specific biosystem
    E-cadherin signaling in keratinocytes
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
    Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
  • Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem (from Pathway Interaction Database)
    Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem
    Stabilization and expansion of the E-cadherin adherens junction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cell-matrix adhesion IC
Inferred by Curator
more info
 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 
regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
 
transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell-cell adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
stress fiber IDA
Inferred from Direct Assay
more info
PubMed 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010972.1NP_001010972.1  zyxin

    See proteins identical to NP_001010972.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC008743, BC009360, BC017183, BU844538
    Consensus CDS
    CCDS5883.1
    UniProtKB/Swiss-Prot
    Q15942
    UniProtKB/TrEMBL
    Q96AF9
    Related
    ENSP00000346417, OTTHUMP00000208858, ENST00000354434, OTTHUMT00000342163
    Conserved Domains (4) summary
    cd09349
    Location:351437
    LIM1_Zyxin; The first LIM domain of Zyxin
    cd09435
    Location:504570
    LIM3_Zyxin; The third LIM domain of Zyxin
    cl09133
    Location:177218
    COG1615; Uncharacterized conserved protein [Function unknown]
    cl02475
    Location:444503
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  2. NM_003461.4NP_003452.1  zyxin

    See proteins identical to NP_003452.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC008743, BC017183
    Consensus CDS
    CCDS5883.1
    UniProtKB/Swiss-Prot
    Q15942
    UniProtKB/TrEMBL
    Q96AF9
    Related
    ENSP00000324422, OTTHUMP00000081863, ENST00000322764, OTTHUMT00000156296
    Conserved Domains (4) summary
    cd09349
    Location:351437
    LIM1_Zyxin; The first LIM domain of Zyxin
    cd09435
    Location:504570
    LIM3_Zyxin; The third LIM domain of Zyxin
    cl09133
    Location:177218
    COG1615; Uncharacterized conserved protein [Function unknown]
    cl02475
    Location:444503
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14 

    Range
    143381245..143391111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250052.1XP_005250109.1  

    See proteins identical to XP_005250109.1

    Conserved Domains (4) summary
    cd09349
    Location:411497
    LIM1_Zyxin; The first LIM domain of Zyxin
    cd09435
    Location:564630
    LIM3_Zyxin; The third LIM domain of Zyxin
    cl09133
    Location:237278
    COG1615; Uncharacterized conserved protein [Function unknown]
    cl02475
    Location:504563
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  2. XM_005250053.1XP_005250110.1  

    Conserved Domains (4) summary
    cd09349
    Location:410496
    LIM1_Zyxin; The first LIM domain of Zyxin
    cd09435
    Location:563629
    LIM3_Zyxin; The third LIM domain of Zyxin
    cl09133
    Location:236277
    COG1615; Uncharacterized conserved protein [Function unknown]
    cl02475
    Location:503562
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

Alternate HuRef

Genomic

  1. AC_000139.1 

    Range
    137415678..137425520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 

    Range
    143015288..143025131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)