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Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25146, updated on 19-Jul-2014
Official Symbol
Cyp17a1provided by RGD
Official Full Name
cytochrome P450, family 17, subfamily a, polypeptide 1provided by RGD
Primary source
RGD:2456
See related
Ensembl:ENSRNOG00000020035
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Cyp17
Summary
steroid hydroxylase that comprises a main component of the steroidogenic pathway; activity culminates in corticosteriod and androgen production in adrenal gland and sex steroid production in gonads [RGD, Feb 2006]
See Cyp17a1 in MapViewer
Location:
1q55
Exon count :
10
Annotation release Status Assembly Chr Location
104 current Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (273852163..273859866, complement)

Chromosome 1 - NC_005100.3Genomic Context describing neighboring genes Neighboring gene sideroflexin 2 Neighboring gene WW domain binding protein 1-like Neighboring gene similar to RIKEN cDNA 2010012O05 Neighboring gene arsenite methyltransferase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
17-alpha-hydroxyprogesterone aldolase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding ISO
Inferred from Sequence Orthology
more info
 
heme binding ISS
Inferred from Sequence or Structural Similarity
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
steroid 17-alpha-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
steroid 17-alpha-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
steroid 17-alpha-monooxygenase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Leydig cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
adrenal gland development IEP
Inferred from Expression Pattern
more info
PubMed 
androgen biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
biphenyl metabolic process IEP
Inferred from Expression Pattern
more info
 
cellular response to antibiotic IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to gonadotropin stimulus IEP
Inferred from Expression Pattern
more info
 
cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 
dibenzo-p-dioxin metabolic process IEP
Inferred from Expression Pattern
more info
 
glucocorticoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
glucocorticoid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
hippocampus development IEP
Inferred from Expression Pattern
more info
 
hormone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
hormone biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
male gonad development IEP
Inferred from Expression Pattern
more info
PubMed 
organic acid metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
ovulation IEP
Inferred from Expression Pattern
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process ISO
Inferred from Sequence Orthology
more info
 
phenol-containing compound metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
phthalate metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of steroid hormone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
progesterone metabolic process ISO
Inferred from Sequence Orthology
more info
 
progesterone metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
response to acetate IEP
Inferred from Expression Pattern
more info
 
response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
response to cytokine IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to fungicide IEP
Inferred from Expression Pattern
more info
PubMed 
response to gonadotropin IEP
Inferred from Expression Pattern
more info
PubMed 
response to herbicide IEP
Inferred from Expression Pattern
more info
 
response to insecticide IEP
Inferred from Expression Pattern
more info
PubMed 
response to ionizing radiation IEP
Inferred from Expression Pattern
more info
PubMed 
response to methylmercury IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to steroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
steroid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
steroid biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
steroid metabolic process ISO
Inferred from Sequence Orthology
more info
 
steroid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
axon ISO
Inferred from Sequence Orthology
more info
 
cell projection IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
steroid 17-alpha-hydroxylase/17,20 lyase
Names
steroid 17-alpha-hydroxylase/17,20 lyase
CYPXVII
P450c17
P450-C17
P45017alpha
cytochrome P450c17
cytochrome P450-C17
cytochrome P450 17A1
cytochrome P450, subfamily 17
Cytochrome P450, subfamily XVII
17-alpha-hydroxyprogesterone aldolase
NP_036885.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012753.2NP_036885.1  steroid 17-alpha-hydroxylase/17,20 lyase precursor

    See proteins identical to NP_036885.1

    Status: PROVISIONAL

    Source sequence(s)
    X14086
    UniProtKB/Swiss-Prot
    P11715
    Related
    ENSRNOP00000027160, ENSRNOT00000027160
    Conserved Domains (1) summary
    pfam00067
    Location:28492
    Blast Score: 1211
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

  1. NC_005100.3 

    Range
    273852163..273859866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231434.1XP_006231496.1  

    See proteins identical to XP_006231496.1

    UniProtKB/Swiss-Prot
    P11715
    Conserved Domains (1) summary
    pfam00067
    Location:28492
    Blast Score: 1211
    p450; Cytochrome P450
  2. XM_006231435.1XP_006231497.1  

    See proteins identical to XP_006231497.1

    UniProtKB/Swiss-Prot
    P11715
    Conserved Domains (1) summary
    pfam00067
    Location:28492
    Blast Score: 1211
    p450; Cytochrome P450

Alternate Rn_Celera

Genomic

  1. AC_000069.1 

    Range
    241321307..241327254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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