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    Nox4 NADPH oxidase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85431, updated on 28-Jul-2015
    Official Symbol
    Nox4provided by RGD
    Official Full Name
    NADPH oxidase 4provided by RGD
    Primary source
    RGD:620600
    See related
    Ensembl:ENSRNOG00000013925
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Summary
    enzyme involved in the production of reactive oxygen species in vascular smooth muscle cells [RGD, Feb 2006]
    Orthologs
    See Nox4 in MapViewer
    Location:
    1q32
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (150796360..150976186)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (157106652..157196482) , (157246099..157285107)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene BRCA1/BRCA2-containing complex, subunit 3-like Neighboring gene 40S ribosomal protein S4, X isoform-like Neighboring gene uncharacterized LOC103691187 Neighboring gene tyrosinase Neighboring gene splicing factor 3A subunit 1-like Neighboring gene glutamate receptor, metabotropic 5

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NAD(P)H oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    modified amino acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    modified amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    superoxide-generating NADPH oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    superoxide-generating NADPH oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    bone resorption IEA
    Inferred from Electronic Annotation
    more info
     
    bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    cell aging ISO
    Inferred from Sequence Orthology
    more info
     
    cell aging ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cell morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to cAMP IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to gamma radiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to transforming growth factor beta stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    homocysteine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    homocysteine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    reactive oxygen species metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
     
    superoxide anion generation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    superoxide metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    superoxide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    superoxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    NADPH oxidase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    NADPH oxidase 4
    Names
    kidney oxidase-1
    kidney superoxide-producing NADPH oxidase
    kox-1
    NP_445976.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053524.1NP_445976.1  NADPH oxidase 4

      See identical proteins and their annotated locations for NP_445976.1

      Status: PROVISIONAL

      Source sequence(s)
      AY027527
      UniProtKB/Swiss-Prot
      Q924V1
      Related
      ENSRNOP00000018990, ENSRNOT00000018990
      Conserved Domains (2) summary
      cd06186
      Location:311577
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam01794
      Location:69205
      Ferric_reduct; Ferric reductase like transmembrane component

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      150796360..150976186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759640.1XP_008757862.1  

      See identical proteins and their annotated locations for XP_008757862.1

      Conserved Domains (2) summary
      cd06186
      Location:263529
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam01794
      Location:21157
      Ferric_reduct; Ferric reductase like transmembrane component
    2. XM_008759643.1XP_008757865.1  

      Conserved Domains (2) summary
      cd06186
      Location:311622
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam01794
      Location:69205
      Ferric_reduct; Ferric reductase like transmembrane component
    3. XM_008759641.1XP_008757863.1  

      See identical proteins and their annotated locations for XP_008757863.1

      Conserved Domains (2) summary
      cd06186
      Location:263529
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam01794
      Location:21157
      Ferric_reduct; Ferric reductase like transmembrane component
    4. XM_008759642.1XP_008757864.1  

      Conserved Domains (2) summary
      cd06186
      Location:237503
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam01794
      Location:4131
      Ferric_reduct; Ferric reductase like transmembrane component

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      139242883..139407667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)