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Ctsd cathepsin D [ Mus musculus (house mouse) ]

Gene ID: 13033, updated on 26-Aug-2014
Official Symbol
Ctsdprovided by MGI
Official Full Name
cathepsin Dprovided by MGI
Primary source
MGI:88562
See related
Ensembl:ENSMUSG00000007891; Vega:OTTMUSG00000018797
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD; CatD
See Ctsd in Epigenomics, MapViewer
Location:
7 F5; 7
Exon count:
9
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 7 NC_000073.6 (142375916..142387870, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene 5054 Neighboring gene interferon induced transmembrane protein 10 Neighboring gene synaptotagmin VIII Neighboring gene troponin I, skeletal, fast 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
aspartic-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
autophagic vacuole assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT epithelial tube branching involved in lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IC
Inferred by Curator
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
lysosome ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
cathepsin D
Names
cathepsin D
NP_034113.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009983.2NP_034113.1  cathepsin D precursor

    See proteins identical to NP_034113.1

    Status: PROVISIONAL

    Source sequence(s)
    X52886
    Consensus CDS
    CCDS22029.1
    UniProtKB/Swiss-Prot
    P18242
    UniProtKB/TrEMBL
    Q3UCD9
    Related
    ENSMUSP00000121203, OTTMUSP00000020357, ENSMUST00000151120, OTTMUST00000045257
    Conserved Domains (3) summary
    pfam07966
    Location:2146
    Blast Score: 109
    A1_Propeptide; A1 Propeptide
    cd05490
    Location:73405
    Blast Score: 1726
    Cathepsin_D2; Cathepsin_D2, pepsin family of proteinases
    pfam00026
    Location:78407
    Blast Score: 1090
    Asp; Eukaryotic aspartyl protease

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000073.6 

    Range
    142375916..142387870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000029.1 

    Range
    142131673..142143627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)