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NPPB natriuretic peptide B [ Homo sapiens (human) ]

Gene ID: 4879, updated on 26-Aug-2014
Official Symbol
NPPBprovided by HGNC
Official Full Name
natriuretic peptide Bprovided by HGNC
Primary source
HGNC:7940
See related
Ensembl:ENSG00000120937; HPRD:08974; MIM:600295; Vega:OTTHUMG00000002389
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BNP
Summary
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Jul 2008]
See NPPB in Epigenomics, MapViewer
Location:
1p36.2
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (11857464..11858935, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11917521..11918992, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate reductase (NAD(P)H) Neighboring gene chloride channel, voltage-sensitive 6 Neighboring gene NPPA antisense RNA 1 Neighboring gene natriuretic peptide A Neighboring gene SET binding factor 1 pseudogene Neighboring gene RNA, U5E small nuclear 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies eight loci associated with blood pressure.
NHGRI GWA Catalog
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
NHGRI GWA Catalog
  • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
    MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
diuretic hormone activity TAS
Traceable Author Statement
more info
PubMed 
hormone activity NAS
Non-traceable Author Statement
more info
PubMed 
receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
body fluid secretion TAS
Traceable Author Statement
more info
PubMed 
cGMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of angiogenesis TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of renal sodium excretion TAS
Traceable Author Statement
more info
PubMed 
positive regulation of urine volume TAS
Traceable Author Statement
more info
PubMed 
receptor guanylyl cyclase signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of blood pressure NAS
Non-traceable Author Statement
more info
PubMed 
regulation of blood vessel size IEA
Inferred from Electronic Annotation
more info
 
regulation of vascular permeability TAS
Traceable Author Statement
more info
PubMed 
regulation of vasodilation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space NAS
Non-traceable Author Statement
more info
PubMed 
protein complex IDA
Inferred from Direct Assay
more info
 
Preferred Names
natriuretic peptides B
Names
natriuretic peptides B
natriuretic protein
brain type natriuretic peptide
gamma-brain natriuretic peptide
natriuretic peptide precursor B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002521.2NP_002512.1  natriuretic peptides B preproprotein

    See proteins identical to NP_002512.1

    Status: REVIEWED

    Source sequence(s)
    AJ708502, BC025785, M25296
    Consensus CDS
    CCDS140.1
    UniProtKB/Swiss-Prot
    P16860
    Related
    ENSP00000365651, OTTHUMP00000002506, ENST00000376468, OTTHUMT00000006854
    Conserved Domains (1) summary
    pfam00212
    Location:97128
    Blast Score: 144
    ANP; Atrial natriuretic peptide

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    11857464..11858935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    11073021..11074492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    11905417..11906888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)