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Rims1 regulating synaptic membrane exocytosis 1 [ Mus musculus (house mouse) ]

Gene ID: 116837, updated on 8-Jan-2015
Official Symbol
Rims1provided by MGI
Official Full Name
regulating synaptic membrane exocytosis 1provided by MGI
Primary source
MGI:MGI:2152971
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rim; RIM1; RIM1a; Serg1; Rab3ip1; RIM1alpha; mKIAA0340; C030033M19Rik
Annotation information
Annotation category: suggests misassembly
Annotation category: partial on reference assembly
See Rims1 in MapViewer
Location:
1 A5; 1
Exon count:
32
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 1 NC_000067.6 (22468191..22805724, complement) , (22288422..22432843, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, subfamily Q, member 5 Neighboring gene eukaryotic translation initiation factor 3, subunit M pseudogene Neighboring gene transmembrane emp24 domain trafficking protein 2 pseudogene Neighboring gene predicted gene, 33278 Neighboring gene predicted gene 7759 Neighboring gene predicted gene 7761

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
    Retrograde endocannabinoid signaling, organism-specific biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
  • Retrograde endocannabinoid signaling, conserved biosystem (from KEGG)
    Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
  • Synaptic vesicle cycle, organism-specific biosystem (from KEGG)
    Synaptic vesicle cycle, organism-specific biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
  • Synaptic vesicle cycle, conserved biosystem (from KEGG)
    Synaptic vesicle cycle, conserved biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0340

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Rab GTPase binding ISO
Inferred from Sequence Orthology
more info
 
SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
calcium ion-dependent exocytosis of neurotransmitter IGI
Inferred from Genetic Interaction
more info
PubMed 
exocytosis IEA
Inferred from Electronic Annotation
more info
 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inhibitory postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic vesicle priming ISO
Inferred from Sequence Orthology
more info
 
protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell IGI
Inferred from Genetic Interaction
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
regulating synaptic membrane exocytosis protein 1
Names
regulating synaptic membrane exocytosis protein 1
RIM 1
Rab3 effector
Rab3 interacting protein 1
rab3-interacting protein 1
rab-3-interacting protein 1
rab3-interacting molecule 1
rab-3-interacting molecule 1
synaptic exocytosis regulator 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012623.1NP_001012641.1  regulating synaptic membrane exocytosis protein 1 isoform 3

    See proteins identical to NP_001012641.1

    Status: PROVISIONAL

    Source sequence(s)
    AY356536
    UniProtKB/Swiss-Prot
    Q99NE5
    Conserved Domains (5) summary
    cd04028
    Location:12051350
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:577703
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:439524
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02318
    Location:155203
    FYVE_2; FYVE-type zinc finger
    pfam12877
    Location:720928
    DUF3827; Domain of unknown function (DUF3827)
  2. NM_001012624.1NP_001012642.1  regulating synaptic membrane exocytosis protein 1 isoform 4

    See proteins identical to NP_001012642.1

    Status: PROVISIONAL

    Source sequence(s)
    AY356537
    UniProtKB/Swiss-Prot
    Q99NE5
    Conserved Domains (4) summary
    cd04028
    Location:11811326
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:577703
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:439524
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02318
    Location:155203
    FYVE_2; FYVE-type zinc finger
  3. NM_001012625.1NP_001012643.1  regulating synaptic membrane exocytosis protein 1 isoform 5

    See proteins identical to NP_001012643.1

    Status: PROVISIONAL

    Source sequence(s)
    AY356538
    UniProtKB/Swiss-Prot
    Q99NE5
    Conserved Domains (5) summary
    cd04028
    Location:11301275
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:577703
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:439524
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02318
    Location:155203
    FYVE_2; FYVE-type zinc finger
    pfam04484
    Location:760879
    DUF566; Family of unknown function (DUF566)
  4. NM_053270.1NP_444500.1  regulating synaptic membrane exocytosis protein 1 isoform 1

    See proteins identical to NP_444500.1

    Status: PROVISIONAL

    Source sequence(s)
    AY356534
    UniProtKB/Swiss-Prot
    Q99NE5
    Conserved Domains (5) summary
    cd04028
    Location:12941439
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:577703
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:761947
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:439524
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02318
    Location:155203
    FYVE_2; FYVE-type zinc finger
  5. NM_183018.2NP_898839.2  regulating synaptic membrane exocytosis protein 1 isoform 2

    See proteins identical to NP_898839.2

    Status: PROVISIONAL

    Source sequence(s)
    AY356535
    UniProtKB/Swiss-Prot
    Q99NE5
    Conserved Domains (5) summary
    cd04028
    Location:12661411
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:577703
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:761970
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:439524
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02318
    Location:155203
    FYVE_2; FYVE-type zinc finger

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000067.6 

    Range
    22288422..22432843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. NC_000067.6 

    Range
    22468191..22805724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000023.1 

    Range
    22160697..22651999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)