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GRIA1 glutamate receptor, ionotropic, AMPA 1 [ Homo sapiens (human) ]

Gene ID: 2890, updated on 11-Sep-2014
Official Symbol
GRIA1provided by HGNC
Official Full Name
glutamate receptor, ionotropic, AMPA 1provided by HGNC
Primary source
HGNC:HGNC:4571
See related
Ensembl:ENSG00000155511; HPRD:00695; MIM:138248; Vega:OTTHUMG00000130148
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUH1; GLUR1; GLURA; GluA1; HBGR1
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
See GRIA1 in Epigenomics, MapViewer
Location:
5q31.1
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 5 NC_000005.10 (153490524..153813869)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (152870084..153193429)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene transfer RNA-Cys (ACA) 1-1 Neighboring gene long intergenic non-protein coding RNA 1470 Neighboring gene family with sequence similarity 114, member A2 Neighboring gene microfibrillar-associated protein 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study of aging.
NHGRI GWA Catalog
Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity.
NHGRI GWA Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog
Genome-wide association study of anthropometric traits in Korcula Island, Croatia.
NHGRI GWA Catalog
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
  • Activation of AMPA receptors, organism-specific biosystem (from REACTOME)
    Activation of AMPA receptors, organism-specific biosystemAMPA receptors are functionally either Ca permeable or Ca impermeable based on the subunit composition. Ca permeability is determined by GluR2 subunit which undergoes post-transcriptional RNA editin...
  • Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem (from REACTOME)
    Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystemNMDA receptors are a subtype of ionotropic glutamate receptors that are specifically activated by a glutamate agonist N-methyl-D-aspartate (NMDA). Activation of NMDA receptor involves opening of the ...
  • Amphetamine addiction, organism-specific biosystem (from KEGG)
    Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
  • Amphetamine addiction, conserved biosystem (from KEGG)
    Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
  • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from WikiPathways)
    Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
  • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
    Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
  • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
    Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
  • BDNF signaling pathway, organism-specific biosystem (from WikiPathways)
    BDNF signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
  • Circadian entrainment, organism-specific biosystem (from KEGG)
    Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Circadian entrainment, conserved biosystem (from KEGG)
    Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Dopaminergic synapse, organism-specific biosystem (from KEGG)
    Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Dopaminergic synapse, conserved biosystem (from KEGG)
    Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • EPHB forward signaling, organism-specific biosystem (from Pathway Interaction Database)
    EPHB forward signaling, organism-specific biosystem
    EPHB forward signaling
  • Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystem (from REACTOME)
    Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystemExcitatory synaptic transmission in the brain is carried out by glutamate receptors through the activation of both ionotropic and metabotropic receptors. Ionotropic glutamate receptors are of three ...
  • Glutamatergic synapse, organism-specific biosystem (from KEGG)
    Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Glutamatergic synapse, conserved biosystem (from KEGG)
    Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Hypothetical Network for Drug Addiction, organism-specific biosystem (from WikiPathways)
    Hypothetical Network for Drug Addiction, organism-specific biosystemAdapted from figure 2 in [http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0040002 Li et al.].
  • Long-term depression, organism-specific biosystem (from KEGG)
    Long-term depression, organism-specific biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
  • Long-term depression, conserved biosystem (from KEGG)
    Long-term depression, conserved biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
  • Long-term potentiation, organism-specific biosystem (from KEGG)
    Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
  • Long-term potentiation, conserved biosystem (from KEGG)
    Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemThe neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein cou...
  • Nicotine addiction, organism-specific biosystem (from KEGG)
    Nicotine addiction, organism-specific biosystemNicotine is one of the main psychoactive ingredients in tobacco that contributes to the harmful tobacco smoking habit. A common feature of addictive drugs, including nicotine, is that they increase d...
  • Nicotine addiction, conserved biosystem (from KEGG)
    Nicotine addiction, conserved biosystemNicotine is one of the main psychoactive ingredients in tobacco that contributes to the harmful tobacco smoking habit. A common feature of addictive drugs, including nicotine, is that they increase d...
  • Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
    Retrograde endocannabinoid signaling, organism-specific biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
  • Retrograde endocannabinoid signaling, conserved biosystem (from KEGG)
    Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
  • Trafficking of AMPA receptors, organism-specific biosystem (from REACTOME)
    Trafficking of AMPA receptors, organism-specific biosystemRepetitive presynaptic activity causes long lasting changes in the postsynaptic transmission by changing the type and the number of AMPA receptors. These changes are brought about by trafficking mec...
  • Trafficking of GluR2-containing AMPA receptors, organism-specific biosystem (from REACTOME)
    Trafficking of GluR2-containing AMPA receptors, organism-specific biosystemTrafficking of GluR2-containing receptors is governed by protein protein interactions that are regulated by phosphorylation events. GluR2 binds NSF and AP2 in the proximal C terminal region and binds...
  • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
    Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
  • Unblocking of NMDA receptor, glutamate binding and activation, organism-specific biosystem (from REACTOME)
    Unblocking of NMDA receptor, glutamate binding and activation, organism-specific biosystemAt resting membrane potential the NMDA receptor is blocked by extracellular Mg2+ ions and therefore is not activated in this state by ligands (glutamate, glycine, NMDA). The voltage block is removed ...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC133252

Gene Ontology Provided by GOA

Function Evidence Code Pubs
PDZ domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity IDA
Inferred from Direct Assay
more info
 
extracellular-glutamate-gated ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
glutamate receptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 
Process Evidence Code Pubs
ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor signaling pathway IDA
Inferred from Direct Assay
more info
 
ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
long-term memory IEA
Inferred from Electronic Annotation
more info
 
receptor internalization IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
synaptic transmission TAS
Traceable Author Statement
more info
 
synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
axonal spine IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite membrane IEA
Inferred from Electronic Annotation
more info
 
dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
neuron spine ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
glutamate receptor 1
Names
glutamate receptor 1
AMPA 1
gluR-1
gluR-A
gluR-K1
AMPA-selective glutamate receptor 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000827.3NP_000818.2  glutamate receptor 1 isoform 1 precursor

    See proteins identical to NP_000818.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AB209094, AK310189, AL120214, DC335107, M81886, X58633
    Consensus CDS
    CCDS4322.1
    UniProtKB/Swiss-Prot
    P42261
    UniProtKB/TrEMBL
    Q59GL5
    Related
    ENSP00000285900, OTTHUMP00000160643, ENST00000285900, OTTHUMT00000252456
    Conserved Domains (5) summary
    cd06390
    Location:26389
    Blast Score: 2128
    PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
    smart00079
    Location:646783
    Blast Score: 449
    PBPe; Eukaryotic homologues of bacterial periplasmic substrate binding proteins
    cd00134
    Location:431520
    Blast Score: 175
    PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
    pfam00060
    Location:538817
    Blast Score: 1015
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:37372
    Blast Score: 604
    ANF_receptor; Receptor family ligand binding region
  2. NM_001114183.1NP_001107655.1  glutamate receptor 1 isoform 2 precursor

    See proteins identical to NP_001107655.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a different coding exon in the 3' region, as compared to variant 1. The resulting isoform (2) is the same length but has a different internal segment, as compared to isoform 1.
    Source sequence(s)
    AB209094, AL120214, DC335107, M64752
    Consensus CDS
    CCDS47318.1
    UniProtKB/Swiss-Prot
    P42261
    UniProtKB/TrEMBL
    Q59GL5
    Conserved Domains (5) summary
    cd06390
    Location:26389
    Blast Score: 2128
    PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
    smart00079
    Location:646783
    Blast Score: 450
    PBPe; Eukaryotic homologues of bacterial periplasmic substrate binding proteins
    cd00134
    Location:431520
    Blast Score: 176
    PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
    pfam00060
    Location:538817
    Blast Score: 1015
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:37372
    Blast Score: 604
    ANF_receptor; Receptor family ligand binding region
  3. NM_001258019.1NP_001244948.1  glutamate receptor 1 isoform 3 precursor

    See proteins identical to NP_001244948.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AB209094, AK295827, AL120214, DC335107
    Consensus CDS
    CCDS58986.1
    UniProtKB/Swiss-Prot
    P42261
    UniProtKB/TrEMBL
    Q59GL5
    Conserved Domains (5) summary
    smart00079
    Location:566703
    Blast Score: 449
    PBPe; Eukaryotic homologues of bacterial periplasmic substrate binding proteins
    cd00134
    Location:351440
    Blast Score: 175
    PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
    pfam00060
    Location:458737
    Blast Score: 1019
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:64292
    Blast Score: 383
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:26309
    Blast Score: 1532
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
  4. NM_001258020.1NP_001244949.1  glutamate receptor 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and has an alternate in-frame exon in place of another exon of the same size. The resulting isoform (4) is shorter at the N-terminus and has a different sequence (but same length) segment in the C-terminus compared to isoform 1.
    Source sequence(s)
    AB209094, AL120214, DC335107
    UniProtKB/TrEMBL
    Q59GL5
    Conserved Domains (5) summary
    smart00079
    Location:551688
    Blast Score: 449
    PBPe; Eukaryotic homologues of bacterial periplasmic substrate binding proteins
    cd00134
    Location:336425
    Blast Score: 175
    PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
    pfam00060
    Location:443722
    Blast Score: 1020
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:1277
    Blast Score: 493
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:1294
    Blast Score: 1710
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
  5. NM_001258021.1NP_001244950.1  glutamate receptor 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate exon in place of the 5'-most exon of variant 1. The resulting isoform (5) has a longer and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB209094, AK295184, AK295827, AK315934, AL120214
    Consensus CDS
    CCDS58987.1
    UniProtKB/Swiss-Prot
    P42261
    UniProtKB/TrEMBL
    Q59GL5
    Related
    ENSP00000428994, OTTHUMP00000224242, ENST00000518783, OTTHUMT00000373902
    Conserved Domains (5) summary
    cd06390
    Location:36399
    Blast Score: 2111
    PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
    smart00079
    Location:656793
    Blast Score: 449
    PBPe; Eukaryotic homologues of bacterial periplasmic substrate binding proteins
    cd00134
    Location:441530
    Blast Score: 177
    PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
    pfam00060
    Location:548827
    Blast Score: 1016
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:47382
    Blast Score: 608
    ANF_receptor; Receptor family ligand binding region
  6. NM_001258022.1NP_001244951.1  glutamate receptor 1 isoform 6

    See proteins identical to NP_001244951.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has an alternate exon in place of the 5'-most exon of variant 1 and has an alternate in-frame exon in place of another exon of the same size. The resulting isoform (6) has a longer and distinct N-terminus and has a different sequence (but same length) segment in the C-terminus compared to isoform 1.
    Source sequence(s)
    AB209094, AK295184, AK315934, AL120214
    Consensus CDS
    CCDS58988.1
    UniProtKB/Swiss-Prot
    P42261
    UniProtKB/TrEMBL
    Q59GL5
    Conserved Domains (5) summary
    cd06390
    Location:36399
    Blast Score: 2111
    PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
    smart00079
    Location:656793
    Blast Score: 450
    PBPe; Eukaryotic homologues of bacterial periplasmic substrate binding proteins
    cd00134
    Location:441530
    Blast Score: 177
    PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
    pfam00060
    Location:548827
    Blast Score: 1016
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:47382
    Blast Score: 608
    ANF_receptor; Receptor family ligand binding region
  7. NM_001258023.1NP_001244952.1  glutamate receptor 1 isoform 7

    See proteins identical to NP_001244952.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an alternate exon in place of the 5'-most exon of variant 1. The resulting isoform (7) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AB209094, AK295039, AL120214
    Consensus CDS
    CCDS58989.1
    UniProtKB/Swiss-Prot
    P42261
    UniProtKB/TrEMBL
    Q59GL5
    Conserved Domains (5) summary
    smart00079
    Location:577714
    Blast Score: 447
    PBPe; Eukaryotic homologues of bacterial periplasmic substrate binding proteins
    cd00134
    Location:362451
    Blast Score: 175
    PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic ...
    pfam00060
    Location:469748
    Blast Score: 1017
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:1303
    Blast Score: 551
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:1320
    Blast Score: 1872
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RNA

  1. NR_047578.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate 5' exon and an alternate 3' exon compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is therefore thought to be non-protein coding.
    Source sequence(s)
    AB209094, AC091960, AK294011, AL120214, DC335107

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000005.10 

    Range
    153490524..153813869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_427776.1 RNA Sequence

Alternate HuRef

Genomic

  1. AC_000137.1 

    Range
    148010721..148334111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 

    Range
    152302506..152626274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)