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    CAT catalase [ Homo sapiens (human) ]

    Gene ID: 847, updated on 19-Jul-2016
    Official Symbol
    CATprovided by HGNC
    Official Full Name
    catalaseprovided by HGNC
    Primary source
    HGNC:HGNC:1516
    See related
    Ensembl:ENSG00000121691 HPRD:00282; MIM:115500; Vega:OTTHUMG00000044353
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
    Orthologs
    Location:
    11p13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (34438925..34472060)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (34460472..34493607)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376622 Neighboring gene corepressor interacting with RBPJ, 1 pseudogene 3 Neighboring gene E74 like ETS transcription factor 5 Neighboring gene uncharacterized LOC105376623

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env Free radical scavengers such as superoxide dismutase (SOD), dimethylthiourea (DMTU) and catalase attenuate morphine and gp160-induced human monocyte apoptosis PubMed
    Tat tat Exposure to HIV-1 clade B Tat protein has a greater inhibition of GSS, GPx1, SOD1, and CAT expression compared with exposure to clade C Tat protein in monocyte-derived immature dendritic cells PubMed
    tat HIV-1 Tat increases catalase and glutathione peroxidase 1 (GPX1) activities in human cardiac myocyte PubMed

    Go to the HIV-1, Human Interaction Database

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC138422, MGC138424

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NADP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aminoacylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    antioxidant activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    catalase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    catalase activity TAS
    Traceable Author Statement
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    heme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on peroxide as acceptor ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    UV protection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    aerobic respiration IEA
    Inferred from Electronic Annotation
    more info
     
    aging IEA
    Inferred from Electronic Annotation
    more info
     
    cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    hemoglobin metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    hydrogen peroxide catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling IEA
    Inferred from Electronic Annotation
    more info
     
    protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    purine nucleotide catabolic process TAS
    Traceable Author Statement
    more info
     
    response to L-ascorbic acid IEA
    Inferred from Electronic Annotation
    more info
     
    response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to cadmium ion IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to fatty acid IEA
    Inferred from Electronic Annotation
    more info
     
    response to hydrogen peroxide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to hyperoxia IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    response to inactivity IEA
    Inferred from Electronic Annotation
    more info
     
    response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    response to lead ion IEA
    Inferred from Electronic Annotation
    more info
     
    response to light intensity IEA
    Inferred from Electronic Annotation
    more info
     
    response to ozone IEA
    Inferred from Electronic Annotation
    more info
     
    response to phenylpropanoid IEA
    Inferred from Electronic Annotation
    more info
     
    response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to reactive oxygen species TAS
    Traceable Author Statement
    more info
     
    response to vitamin A IEA
    Inferred from Electronic Annotation
    more info
     
    response to vitamin E IEA
    Inferred from Electronic Annotation
    more info
     
    triglyceride metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peroxisomal matrix TAS
    Traceable Author Statement
    more info
     
    peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013339.1 RefSeqGene

      Range
      5001..38136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001752.3NP_001743.1  catalase

      See identical proteins and their annotated locations for NP_001743.1

      Status: REVIEWED

      Source sequence(s)
      AK291585, AL035079, AW023382
      Consensus CDS
      CCDS7891.1
      UniProtKB/Swiss-Prot
      P04040
      Related
      ENSP00000241052, OTTHUMP00000041455, ENST00000241052, OTTHUMT00000103197
      Conserved Domains (2) summary
      cd08156
      Location:68497
      catalase_clade_3; Clade 3 of the heme-binding enzyme catalase
      COG0753
      Location:26490
      KatE; Catalase [Inorganic ion transport and metabolism]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      34438925..34472060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      34459461..34492601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)