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EIF4E eukaryotic translation initiation factor 4E [ Homo sapiens (human) ]

Gene ID: 1977, updated on 13-Jan-2015
Official Symbol
EIF4Eprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 4Eprovided by HGNC
Primary source
HGNC:HGNC:3287
See related
HPRD:00591; MIM:133440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBP; EIF4F; AUTS19; EIF4E1; EIF4EL1
Summary
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Orthologs
See EIF4E in MapViewer
Location:
4q23
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 4 NC_000004.12 (98878456..98930635, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (99799607..99851786, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene tetraspanin 5 Neighboring gene basic transcription factor 3 pseudogene 13 Neighboring gene tubulin folding cofactor A pseudogene 3 Neighboring gene Putative protein FAM177A2 Neighboring gene NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) pseudogene 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
Pr55(Gag) gag Expression of HIV-1 Gag requires eIF4E, eIF4G, and eIF4A (eIF4F) binding to the viral 5'UTR PubMed
Vpr vpr HIV-1 Vpr expression in HEK293 cells is sufficient to decrease the levels of phosphorylated eIF4E and 4E-BP1 PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC111573

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA cap binding TAS
Traceable Author Statement
more info
PubMed 
eukaryotic initiation factor 4G binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
gene expression TAS
Traceable Author Statement
more info
 
insulin receptor signaling pathway TAS
Traceable Author Statement
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA poly(A) tail shortening TAS
Traceable Author Statement
more info
 
positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
translation TAS
Traceable Author Statement
more info
 
translational initiation TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RISC complex IDA
Inferred from Direct Assay
more info
PubMed 
chromatoid body IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytoplasmic mRNA processing body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic translation initiation factor 4F complex IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
mRNA cap binding complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
eukaryotic translation initiation factor 4E
Names
eukaryotic translation initiation factor 4E
eIF-4E
eIF-4F 25 kDa subunit
mRNA cap-binding protein
eukaryotic translation initiation factor 4E-like 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130678.1NP_001124150.1  eukaryotic translation initiation factor 4E isoform 3

    See proteins identical to NP_001124150.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate exon for the 5' UTR and 5' coding region that results in translation initiation from a distinct ATG, compared to variant 1, and an isoform (3) with a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC093836, BC107715, DC388666
    Consensus CDS
    CCDS47109.1
    UniProtKB/Swiss-Prot
    P06730
    UniProtKB/TrEMBL
    Q32Q75
    UniProtKB/TrEMBL
    X5D7E3
    Conserved Domains (1) summary
    pfam01652
    Location:58220
    IF4E; Eukaryotic initiation factor 4E
  2. NM_001130679.1NP_001124151.1  eukaryotic translation initiation factor 4E isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an additional in-frame exon in the 3' coding region, compared to variant 1, that results in a protein (isoform 2) with a longer C-terminus, compared to isoform 1.
    Source sequence(s)
    AC019131, AC093836, BM849222
    Consensus CDS
    CCDS54779.1
    UniProtKB/Swiss-Prot
    P06730
    Conserved Domains (1) summary
    pfam01652
    Location:38231
    IF4E; Eukaryotic initiation factor 4E
  3. NM_001968.3NP_001959.1  eukaryotic translation initiation factor 4E isoform 1

    See proteins identical to NP_001959.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shortest isoform (1).
    Source sequence(s)
    AC019131, AC093836, M15353
    Consensus CDS
    CCDS34031.1
    UniProtKB/Swiss-Prot
    P06730
    Conserved Domains (1) summary
    pfam01652
    Location:38200
    IF4E; Eukaryotic initiation factor 4E

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000004.12 

    Range
    98878456..98930635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714126.1XP_006714189.1  

    UniProtKB/TrEMBL
    D6RBW1
    Conserved Domains (1) summary
    pfam01652
    Location:66228
    IF4E; Eukaryotic initiation factor 4E
  2. XM_006714127.1XP_006714190.1  

    Conserved Domains (1) summary
    pfam01652
    Location:38133
    IF4E; Eukaryotic initiation factor 4E

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 

    Range
    99776200..99828797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000136.1 

    Range
    95536964..95590638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)