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Rbpj recombination signal binding protein for immunoglobulin kappa J region [ Mus musculus (house mouse) ]

Gene ID: 19664, updated on 20-Nov-2014
Official Symbol
Rbpjprovided by MGI
Official Full Name
recombination signal binding protein for immunoglobulin kappa J regionprovided by MGI
Primary source
MGI:MGI:96522
See related
Ensembl:ENSMUSG00000039191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CBF1; RBP-J; RBPjk; Igkjrb; Rbpsuh; Igkrsbp; AI843960; RBP-J kappa
See Rbpj in Epigenomics, MapViewer
Location:
5 C1-C3; 5 29.37 cM
Exon count:
19
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 5 NC_000071.6 (53466115..53657445)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30519 Neighboring gene small integral membrane protein 20 Neighboring gene cholecystokinin A receptor Neighboring gene TBC1 domain family, member 19

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISA
Inferred from Sequence Alignment
more info
PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISO
Inferred from Sequence Orthology
more info
PubMed 
RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II repressing transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Clara cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Notch signaling pathway involved in arterial endothelial cell fate commitment IC
Inferred by Curator
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
arterial endothelial cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
atrioventricular canal development IMP
Inferred from Mutant Phenotype
more info
PubMed 
auditory receptor cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel endothelial cell fate specification IGI
Inferred from Genetic Interaction
more info
PubMed 
blood vessel lumenization IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac left ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of heart left/right asymmetry TAS
Traceable Author Statement
more info
PubMed 
dorsal aorta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocardium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermal cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial to mesenchymal transition involved in endocardial cushion formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hair follicle maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart looping TAS
Traceable Author Statement
more info
PubMed 
hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
humoral immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-4 secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
labyrinthine layer blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
myeloid dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
pituitary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERBB signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Notch signaling pathway involved in heart induction TAS
Traceable Author Statement
more info
PubMed 
positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation involved in heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ephrin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription of Notch receptor target IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription of Notch receptor target ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISA
Inferred from Sequence Alignment
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of cell adhesion involved in heart morphogenesis IC
Inferred by Curator
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of timing of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
sebaceous gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
secondary heart field specification IGI
Inferred from Genetic Interaction
more info
PubMed 
secondary heart field specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatic stem cell maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
somitogenesis TAS
Traceable Author Statement
more info
PubMed 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
ventricular trabecula myocardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
MAML1-RBP-Jkappa- ICN1 complex ISO
Inferred from Sequence Orthology
more info
 
cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISA
Inferred from Sequence Alignment
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
recombining binding protein suppressor of hairless
Names
recombining binding protein suppressor of hairless

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080927.2NP_001074396.1  recombining binding protein suppressor of hairless isoform 2

    See proteins identical to NP_001074396.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC084054, AK028363, AK080359, AK132145, BY716845
    Consensus CDS
    CCDS51504.1
    UniProtKB/Swiss-Prot
    P31266
    UniProtKB/TrEMBL
    Q3UM17
    Related
    ENSMUSP00000109496, ENSMUST00000113865
    Conserved Domains (3) summary
    pfam09270
    Location:166315
    BTD; Beta-trefoil DNA-binding domain
    cd01176
    Location:337433
    IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
    pfam09271
    Location:34165
    LAG1-DNAbind; LAG1, DNA binding
  2. NM_001080928.1NP_001074397.1  recombining binding protein suppressor of hairless isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC084054, AK028363, AK132145, BB839243, CD540070
    Consensus CDS
    CCDS51503.1
    UniProtKB/TrEMBL
    E9Q7W0
    Related
    ENSMUSP00000084618, ENSMUST00000087360
    Conserved Domains (3) summary
    pfam09270
    Location:164313
    BTD; Beta-trefoil DNA-binding domain
    cd01176
    Location:335431
    IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
    pfam09271
    Location:32163
    LAG1-DNAbind; LAG1, DNA binding
  3. NM_001277116.1NP_001264045.1  recombining binding protein suppressor of hairless isoform 4

    See proteins identical to NP_001264045.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, contains an alternate exon in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK028363, AK132145, AK152746
    Conserved Domains (3) summary
    pfam09270
    Location:186335
    BTD; Beta-trefoil DNA-binding domain
    cd01176
    Location:357453
    IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
    pfam09271
    Location:54185
    LAG1-DNAbind; LAG1, DNA binding
  4. NM_009035.5NP_033061.3  recombining binding protein suppressor of hairless isoform 1

    See proteins identical to NP_033061.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK028363, AK132145, AK152746, BY155397
    Consensus CDS
    CCDS19292.1
    UniProtKB/Swiss-Prot
    P31266
    Related
    ENSMUSP00000040694, ENSMUST00000037618
    Conserved Domains (3) summary
    pfam09270
    Location:205354
    BTD; Beta-trefoil DNA-binding domain
    cd01176
    Location:376472
    IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
    pfam09271
    Location:73204
    LAG1-DNAbind; LAG1, DNA binding

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000071.6 

    Range
    53466115..53657445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503797.1XP_006503860.1  

    Conserved Domains (3) summary
    pfam09270
    Location:170319
    BTD; Beta-trefoil DNA-binding domain
    cd01176
    Location:341437
    IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
    pfam09271
    Location:38169
    LAG1-DNAbind; LAG1, DNA binding
  2. XM_006503795.1XP_006503858.1  

    Conserved Domains (3) summary
    pfam09270
    Location:261410
    BTD; Beta-trefoil DNA-binding domain
    cd01176
    Location:432528
    IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
    pfam09271
    Location:129260
    LAG1-DNAbind; LAG1, DNA binding
  3. XM_006503799.1XP_006503862.1  

    See proteins identical to XP_006503862.1

    UniProtKB/TrEMBL
    Q3U6F1
    Conserved Domains (3) summary
    pfam09270
    Location:144293
    BTD; Beta-trefoil DNA-binding domain
    cd01176
    Location:315411
    IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
    pfam09271
    Location:12143
    LAG1-DNAbind; LAG1, DNA binding
  4. XM_006503796.1XP_006503859.1  

    Conserved Domains (3) summary
    pfam09270
    Location:208357
    BTD; Beta-trefoil DNA-binding domain
    cd01176
    Location:379475
    IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
    pfam09271
    Location:76207
    LAG1-DNAbind; LAG1, DNA binding
  5. XM_006503798.1XP_006503861.1  

    See proteins identical to XP_006503861.1

    UniProtKB/TrEMBL
    Q3U6F1
    Conserved Domains (3) summary
    pfam09270
    Location:144293
    BTD; Beta-trefoil DNA-binding domain
    cd01176
    Location:315411
    IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
    pfam09271
    Location:12143
    LAG1-DNAbind; LAG1, DNA binding

Alternate Mm_Celera

Genomic

  1. AC_000027.1 

    Range
    50938216..51041035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)