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    Drd4 dopamine receptor D4 [ Mus musculus (house mouse) ]

    Gene ID: 13491, updated on 27-Jun-2015
    Official Symbol
    Drd4provided by MGI
    Official Full Name
    dopamine receptor D4provided by MGI
    Primary source
    MGI:MGI:94926
    See related
    Ensembl:ENSMUSG00000025496
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D4R; Drd-4; AW125663
    Orthologs
    See Drd4 in Epigenomics, MapViewer
    Location:
    7 F5; 7 86.6 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (141291976..141296238)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (148477905..148480900)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene cadherin-related family member 5 Neighboring gene secretin Neighboring gene deformed epidermal autoregulatory factor 1 (Drosophila) Neighboring gene transmembrane protein 80 Neighboring gene EPS8-like 2 Neighboring gene RIKEN cDNA B230206H07 gene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein coupled amine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    dopamine binding ISO
    Inferred from Sequence Orthology
    more info
     
    dopamine neurotransmitter receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    dopamine neurotransmitter receptor activity, coupled via Gi/Go IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopamine neurotransmitter receptor activity, coupled via Gi/Go ISO
    Inferred from Sequence Orthology
    more info
     
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase-inhibiting dopamine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adenylate cyclase-inhibiting dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    arachidonic acid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    associative learning ISO
    Inferred from Sequence Orthology
    more info
     
    behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
     
    behavioral response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cAMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    olfactory learning ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of excitatory postsynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of penile erection ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sodium:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of inhibitory postsynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    response to amphetamine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to histamine ISO
    Inferred from Sequence Orthology
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of chemical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    short-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    synaptic transmission, dopaminergic ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    D(4) dopamine receptor
    Names
    D(4) dopamine receptor
    d(2C) dopamine receptor
    dopamine D4 receptor
    dopamine receptor 4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007878.2NP_031904.1  D(4) dopamine receptor

      See identical proteins and their annotated locations for NP_031904.1

      Status: PROVISIONAL

      Source sequence(s)
      BC016086
      Consensus CDS
      CCDS22007.1
      UniProtKB/Swiss-Prot
      P51436
      Related
      ENSMUSP00000026569, ENSMUST00000026569
      Conserved Domains (1) summary
      pfam00001
      Location:54368
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

      Range
      141291976..141296238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006536156.2XP_006536219.1  

      Conserved Domains (1) summary
      pfam00001
      Location:16330
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    Alternate Mm_Celera

    Genomic

    1. AC_000029.1 Alternate Mm_Celera

      Range
      141085754..141088749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)