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HUL5 ubiquitin-ubiquitin ligase HUL5 [ Saccharomyces cerevisiae S288c ]

Gene ID: 852736, updated on 6-Jul-2014
Gene symbol
HUL5
Gene description
ubiquitin-ubiquitin ligase HUL5
Primary source
SGD:S000003109
Locus tag
YGL141W
Gene type
protein coding
RNA name
ubiquitin-ubiquitin ligase HUL5
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See HUL5 in MapViewer
Location:
chromosome: VII
Exon count :
1
Sequence:
Chromosome: VII; NC_001139.9 (238353..241085)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Mrf1p Neighboring gene Gpi10p Neighboring gene hypothetical protein Neighboring gene Flc3p

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-ubiquitin ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ER-associated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
free ubiquitin chain polymerization IMP
Inferred from Mutant Phenotype
more info
 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
proteasome complex IDA
Inferred from Direct Assay
more info
PubMed 
Names
ubiquitin-ubiquitin ligase HUL5
NP_011374.1
  • Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 

    Range
    238353..241085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181006.1NP_011374.1  ubiquitin-ubiquitin ligase HUL5 [Saccharomyces cerevisiae S288c]

    See proteins identical to NP_011374.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P53119
    Conserved Domains (2) summary
    COG5021
    Location:35910
    Blast Score: 2062
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00078
    Location:558908
    Blast Score: 1023
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

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