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    OPRM1 opioid receptor, mu 1 [ Homo sapiens (human) ]

    Gene ID: 4988, updated on 30-Jun-2015
    Official Symbol
    OPRM1provided by HGNC
    Official Full Name
    opioid receptor, mu 1provided by HGNC
    Primary source
    HGNC:HGNC:8156
    See related
    Ensembl:ENSG00000112038; HPRD:02484; MIM:600018; Vega:OTTHUMG00000015870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MOP; MOR; LMOR; MOR1; OPRM; M-OR-1
    Summary
    This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]
    Orthologs
    See OPRM1 in Epigenomics, MapViewer
    Location:
    6q24-q25
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (154010496..154246867)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (154331631..154568001)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene MT-ND4 pseudogene 13 Neighboring gene high mobility group box 3 pseudogene 19 Neighboring gene interaction protein for cytohesin exchange factors 1 Neighboring gene ribosomal protein L17 pseudogene 24 Neighboring gene uncharacterized LOC105378067 Neighboring gene CNKSR family member 3 Neighboring gene atherin-like

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
    NHGRI GWA Catalog
    Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Cyclic d-Phe-Cys-Tyr-d-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP), mu-opioid receptor-selective antagonist, significantly delay the febrile response induced by HIV-1 gp120, suggesting that mu-opioid receptors can regulate gp120-induced fever PubMed
    env HIV-1 gp120 induces desensitization of a mu-opioid-receptor-mediated response in brain periaqueductal gray neurons PubMed
    env HIV-1 gp120 upregulates mu opioid receptor (MOR) expression in TPA-differentiated HL-60 cells; treatment with TNF-alpha neutralizing antibody as well as anti-TNF-alpha receptor type II (TNFR-II) antibody, inhibits gp120-induced upregulation of MOR PubMed
    env HIV-1 gp120 upregulates mu opiate receptor expression in human vascular endothelium; in contrast, morphine decreases mu opioid receptor expression PubMed
    Tat tat The synergistic upregulation of CXCL10 expression by HIV-1 Tat and IFN-gamma is inhibited by mu-opioid receptor (MOR) antagonist beta-funaltrexamine in human astrocytes PubMed
    tat Morphine treatment in the presence of Tat significantly increases intracellular expression of opioid receptors (mu, delta, and kappa) and prevents morphine-induced cell surface opioid receptor down-regulation in microglia PubMed

    Go to the HIV-1, Human Interaction Database

    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • Estrogen signaling pathway, organism-specific biosystem (from KEGG)
      Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
    • Estrogen signaling pathway, conserved biosystem (from KEGG)
      Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • G-protein activation, organism-specific biosystem (from REACTOME)
      G-protein activation, organism-specific biosystemReceptor activated heterotrimeric G proteins consist of the Galpha and the tightly associated Gbeta-gamma subunits. When a ligand binds to a G protein-coupled receptor, it stabilises a conformation ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
    • IL4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL4-mediated signaling events, organism-specific biosystem
      IL4-mediated signaling events
    • Morphine addiction, organism-specific biosystem (from KEGG)
      Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Morphine addiction, conserved biosystem (from KEGG)
      Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Opioid Signalling, organism-specific biosystem (from REACTOME)
      Opioid Signalling, organism-specific biosystemOpioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as...
    • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
      Peptide GPCRs, organism-specific biosystem
      Peptide GPCRs
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • TCR Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TCR Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0403

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein alpha-subunit binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    G-protein coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    beta-endorphin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    morphine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    morphine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    voltage-gated calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
    Traceable Author Statement
    more info
    PubMed 
    adenylate cyclase-activating dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to morphine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Wnt protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of adenylate cyclase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cAMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of nitric oxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    neuropeptide signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    opioid receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phospholipase C-activating G-protein coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cAMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of nitric oxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of N-methyl-D-aspartate selective glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sensory perception NAS
    Non-traceable Author Statement
    more info
    PubMed 
    sensory perception of pain IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    sensory perception of pain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    mu-type opioid receptor
    Names
    mu opiate receptor
    mu opioid receptor hMOR-1a

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021208.1 RefSeqGene

      Range
      4996..241366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000914.4NP_000905.3  mu-type opioid receptor isoform MOR-1

      See identical proteins and their annotated locations for NP_000905.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant MOR-1i. The resulting isoform (MOR-1) has a shorter N-terminus, compared to isoform MOR-1i. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.
      Source sequence(s)
      AL132774, FJ041291
      Consensus CDS
      CCDS55070.1
      UniProtKB/TrEMBL
      G8XRH5
      UniProtKB/Swiss-Prot
      P35372
      Conserved Domains (2) summary
      pfam00001
      Location:93338
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:79283
      7tm_4; Olfactory receptor
    2. NM_001008503.2NP_001008503.2  mu-type opioid receptor isoform MOR-1O

      See identical proteins and their annotated locations for NP_001008503.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1O) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1O) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1i.
      Source sequence(s)
      AY036623, FJ041291
      Consensus CDS
      CCDS43517.1
      UniProtKB/TrEMBL
      G8XRH5
      UniProtKB/Swiss-Prot
      P35372
      Related
      ENSP00000338381, OTTHUMP00000225133, ENST00000337049, OTTHUMT00000375913
      Conserved Domains (2) summary
      pfam00001
      Location:93338
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam10328
      Location:79283
      7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx
    3. NM_001008504.3NP_001008504.2  mu-type opioid receptor isoform MOR-1A

      See identical proteins and their annotated locations for NP_001008504.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1A) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1A) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.
      Source sequence(s)
      AY309001, AY364890, FJ041291
      Consensus CDS
      CCDS47508.1
      UniProtKB/TrEMBL
      G8XRH5
      UniProtKB/Swiss-Prot
      P35372
      Conserved Domains (2) summary
      pfam00001
      Location:93338
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam10328
      Location:79283
      7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx
    4. NM_001008505.2NP_001008505.2  mu-type opioid receptor isoform MOR-1X

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1X), also known as MOR-1R, represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1X) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1i.
      Source sequence(s)
      AL136444, AY036622, FJ041291
      Consensus CDS
      CCDS43518.1
      UniProtKB/TrEMBL
      G8XRH5
      UniProtKB/Swiss-Prot
      P35372
      Related
      ENSP00000229768, OTTHUMP00000225139, ENST00000229768, OTTHUMT00000375933
      Conserved Domains (2) summary
      pfam00001
      Location:93338
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam10328
      Location:79283
      7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx
    5. NM_001145279.3NP_001138751.1  mu-type opioid receptor isoform MOR-1i

      See identical proteins and their annotated locations for NP_001138751.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1i) encodes the longest isoform (MOR-1i). Variants MOR-1i and MOR-1CA encode the same isoform (MOR-1i).
      Source sequence(s)
      AL132774, DQ680044, EU340241
      Consensus CDS
      CCDS47503.1
      UniProtKB/TrEMBL
      B8K2Q5
      UniProtKB/Swiss-Prot
      P35372
      Conserved Domains (2) summary
      pfam00001
      Location:186431
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:172376
      7tm_4; Olfactory receptor
    6. NM_001145280.3NP_001138752.1  mu-type opioid receptor isoform MOR-1G1

      See identical proteins and their annotated locations for NP_001138752.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1G1) lacks two alternate exons and uses a downstream start codon, compared to variant MOR-1i. The resulting isoform (MOR-1G1) has a shorter N-terminus, compared to isoform MOR-1i. Variants MOR-1G1, MOR-1K1, and MOR-1K2 encode the same isoform (MOR-1G1).
      Source sequence(s)
      AL132774, DQ680044, EU340242
      Consensus CDS
      CCDS55071.1
      UniProtKB/TrEMBL
      B8K2Q5
      UniProtKB/Swiss-Prot
      P35372
      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    7. NM_001145281.2NP_001138753.1  mu-type opioid receptor isoform MOR-1G2

      See identical proteins and their annotated locations for NP_001138753.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1G2) lacks two alternate exons and uses an alternate splice site in the 5' region, compared to variant MOR-1i. The resulting isoform (MOR-1G2) has a shorter and distinct N-terminus, compared to isoform MOR-1i.
      Source sequence(s)
      AL132774, DQ680044, EU340243
      Consensus CDS
      CCDS55068.1
      UniProtKB/TrEMBL
      B8K2Q5
      UniProtKB/Swiss-Prot
      P35372
      Conserved Domains (2) summary
      pfam00001
      Location:15257
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam10328
      Location:15202
      7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx
    8. NM_001145282.2NP_001138754.1  mu-type opioid receptor isoform MOR-1B1

      See identical proteins and their annotated locations for NP_001138754.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1B1) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1B1) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1i.
      Source sequence(s)
      AL136444, AY225404, FJ041291
      Consensus CDS
      CCDS47504.1
      UniProtKB/TrEMBL
      G8XRH5
      UniProtKB/Swiss-Prot
      P35372
      Related
      ENSP00000410497, OTTHUMP00000225135, ENST00000452687, OTTHUMT00000375915
      Conserved Domains (2) summary
      pfam00001
      Location:93338
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam10328
      Location:79283
      7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx
    9. NM_001145283.2NP_001138755.1  mu-type opioid receptor isoform MOR-1B2

      See identical proteins and their annotated locations for NP_001138755.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1B2) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1B2) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i.
      Source sequence(s)
      AL132774, AY309005, FJ041291
      Consensus CDS
      CCDS47505.1
      UniProtKB/TrEMBL
      G8XRH5
      UniProtKB/Swiss-Prot
      P35372
      Related
      ENSP00000413752, OTTHUMP00000225168, ENST00000435918, OTTHUMT00000375972
      Conserved Domains (2) summary
      pfam00001
      Location:93338
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam10328
      Location:79283
      7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx
    10. NM_001145284.3NP_001138756.1  mu-type opioid receptor isoform MOR-1B3

      See identical proteins and their annotated locations for NP_001138756.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1B3) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1B3) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1i.
      Source sequence(s)
      AL132774, AY309006, FJ041291
      Consensus CDS
      CCDS47506.1
      UniProtKB/TrEMBL
      G8XRH5
      UniProtKB/Swiss-Prot
      P35372
      Related
      ENSP00000399359, OTTHUMP00000225167, ENST00000414028, OTTHUMT00000375971
      Conserved Domains (2) summary
      pfam00001
      Location:93338
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam10328
      Location:79283
      7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx
    11. NM_001145285.2NP_001138757.1  mu-type opioid receptor isoform MOR-1B4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1B4) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1B4) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i.
      Source sequence(s)
      AL136444, AY309007, FJ041291
      Consensus CDS
      CCDS55069.1
      UniProtKB/TrEMBL
      G8XRH5
      UniProtKB/Swiss-Prot
      P35372
      Related
      ENSP00000430097, OTTHUMP00000225165, ENST00000524163, OTTHUMT00000375969
      Conserved Domains (2) summary
      pfam00001
      Location:93338
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:79283
      7tm_4; Olfactory receptor
    12. NM_001145286.2NP_001138758.1  mu-type opioid receptor isoform MOR-1B5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1B5) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1B5) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1i.
      Source sequence(s)
      AL132774, AY309008, FJ041291
      Consensus CDS
      CCDS47507.1
      UniProtKB/TrEMBL
      G8XRH5
      UniProtKB/Swiss-Prot
      P35372
      Related
      ENSP00000403549, OTTHUMP00000225164, ENST00000419506, OTTHUMT00000375968
      Conserved Domains (2) summary
      pfam00001
      Location:93338
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:79283
      7tm_4; Olfactory receptor
    13. NM_001145287.2NP_001138759.1  mu-type opioid receptor isoform MOR-1G1

      See identical proteins and their annotated locations for NP_001138759.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1K1) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant MOR-1i. The resulting isoform (MOR-1G1) has a shorter N-terminus, compared to isoform MOR-1i. Variants MOR-1G1, MOR-1K1, and MOR-1K2 encode the same isoform (MOR-1G1).
      Source sequence(s)
      AL132774, AL136444, EU362990
      Consensus CDS
      CCDS55071.1
      UniProtKB/Swiss-Prot
      P35372
      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    14. NM_001285522.1NP_001272451.1  mu-type opioid receptor isoform MOR-1S

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1S) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and lacks two alternate internal exons, compared to variant MOR-1i. The resulting isoform (MOR-1S) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.
      Source sequence(s)
      AL132774, FJ041290, FJ041291
      UniProtKB/TrEMBL
      G8XRH4
      UniProtKB/TrEMBL
      G8XRH5
    15. NM_001285523.1NP_001272452.1  mu-type opioid receptor isoform MOR-1A2

      See identical proteins and their annotated locations for NP_001272452.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1A2) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1A2) has a shorter N-terminus and a distinct C-terminus, compared to isoform MOR-1i. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.
      Source sequence(s)
      AY195733, FJ041291, JX914655
      UniProtKB/TrEMBL
      G8XRH5
      UniProtKB/TrEMBL
      L0E130
      UniProtKB/Swiss-Prot
      P35372
      Related
      ENSP00000353598, ENST00000360422
      Conserved Domains (2) summary
      pfam00001
      Location:93338
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:79283
      7tm_4; Olfactory receptor
    16. NM_001285524.1NP_001272453.1  mu-type opioid receptor isoform MOR-1i

      See identical proteins and their annotated locations for NP_001272453.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1CA) represents use of an alternate promoter and 5' UTR, compared to variant MOR-1i. Variants MOR-1i and MOR-1CA encode the same isoform (MOR-1i).
      Source sequence(s)
      AL132774, FJ041292
      Consensus CDS
      CCDS47503.1
      UniProtKB/Swiss-Prot
      P35372
      Conserved Domains (2) summary
      pfam00001
      Location:186431
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:172376
      7tm_4; Olfactory receptor
    17. NM_001285526.1NP_001272455.1  mu-type opioid receptor isoform MOR-1G1

      See identical proteins and their annotated locations for NP_001272455.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1K2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant MOR-1i. The resulting isoform (MOR-1G1) has a shorter N-terminus, compared to isoform MOR-1i. Variants MOR-1G1, MOR-1K1, and MOR-1K2 encode the same isoform (MOR-1G1).
      Source sequence(s)
      AL132774, AL136444, EU360599
      Consensus CDS
      CCDS55071.1
      UniProtKB/Swiss-Prot
      P35372
      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    18. NM_001285527.1NP_001272456.1  mu-type opioid receptor isoform MOR-1W

      See identical proteins and their annotated locations for NP_001272456.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1W; also known as mu3-like and MOR-1A delta) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-1W) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i.
      Source sequence(s)
      AY364890
      UniProtKB/Swiss-Prot
      P35372
      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam10328
      Location:56183
      7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx
    19. NM_001285528.1NP_001272457.1  mu-type opioid receptor isoform MOR-3

      See identical proteins and their annotated locations for NP_001272457.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-3; also known as mu3) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1i. The resulting isoform (MOR-3) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1i.
      Source sequence(s)
      AY195733, AY364890
      UniProtKB/Swiss-Prot
      P35372
      Conserved Domains (1) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RNA

    1. NR_104348.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1Y3; also known as MOR-1V) represents use of an alternate promoter and contains an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL132774, FJ041291, FJ041293, FJ041294
    2. NR_104349.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1Y2) represents use of an alternate promoter and contains an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AY225404, FJ041291, FJ041294
    3. NR_104350.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1Z) represents use of an alternate promoter and lacks an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL132774, FJ041291, HQ699462
    4. NR_104351.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1Y) represents use of an alternate promoter and contains an alternate internal exon, compared to variant MOR-1i. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL132774, AY309009, FJ041291

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

      Range
      154010496..154246867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011535849.1XP_011534151.1  

      See identical proteins and their annotated locations for XP_011534151.1

      Conserved Domains (2) summary
      pfam00001
      Location:186431
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:172376
      7tm_4; Olfactory receptor
    2. XM_006715497.2XP_006715560.1  

    3. XM_011535862.1XP_011534164.1  

      See identical proteins and their annotated locations for XP_011534164.1

      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    4. XM_011535856.1XP_011534158.1  

      See identical proteins and their annotated locations for XP_011534158.1

      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    5. XM_011535855.1XP_011534157.1  

      See identical proteins and their annotated locations for XP_011534157.1

      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    6. XM_011535853.1XP_011534155.1  

      See identical proteins and their annotated locations for XP_011534155.1

      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    7. XM_011535861.1XP_011534163.1  

      See identical proteins and their annotated locations for XP_011534163.1

      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    8. XM_011535860.1XP_011534162.1  

      See identical proteins and their annotated locations for XP_011534162.1

      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    9. XM_011535858.1XP_011534160.1  

      See identical proteins and their annotated locations for XP_011534160.1

      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    10. XM_011535857.1XP_011534159.1  

      See identical proteins and their annotated locations for XP_011534159.1

      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    11. XM_011535852.1XP_011534154.1  

      See identical proteins and their annotated locations for XP_011534154.1

      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    12. XM_011535859.1XP_011534161.1  

      See identical proteins and their annotated locations for XP_011534161.1

      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    13. XM_011535851.1XP_011534153.1  

      See identical proteins and their annotated locations for XP_011534153.1

      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    14. XM_011535854.1XP_011534156.1  

      See identical proteins and their annotated locations for XP_011534156.1

      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56183
      7tm_4; Olfactory receptor
    15. XM_011535850.1XP_011534152.1  

      Conserved Domains (2) summary
      pfam00001
      Location:24269
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:26214
      7tm_4; Olfactory receptor

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      154595701..154831638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)