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    Cxcl12 chemokine (C-X-C motif) ligand 12 [ Mus musculus (house mouse) ]

    Gene ID: 20315, updated on 24-Jun-2016
    Official Symbol
    Cxcl12provided by MGI
    Official Full Name
    chemokine (C-X-C motif) ligand 12provided by MGI
    Primary source
    MGI:MGI:103556
    See related
    Ensembl:ENSMUSG00000061353 Vega:OTTMUSG00000022768
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pbsf; Sdf1; Tlsf; Tpar1; Scyb12
    Summary
    This gene encodes a member of the alpha chemokine protein family. The encoded protein is secreted and functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4. The encoded protein plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
    Orthologs
    Location:
    6 54.81 cM; 6 F1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (117168535..117181368)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (117118553..117131386)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36873 Neighboring gene uncharacterized LOC102631679 Neighboring gene ribosomal protein L28, pseudogene 4 Neighboring gene predicted gene 6227

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    CXCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    CXCR chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    chemoattractant activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chemokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    ameboidal-type cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    brain development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chemokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    dopaminergic neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    germ cell development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    germ cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    induction of positive chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of leukocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
     
    neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    organ regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    patterning of blood vessels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of axon extension involved in axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium ion import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    telencephalon cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    stromal cell-derived factor 1
    Names
    12-O-tetradecanoylphorbol 13-acetate repressed protein 1
    pre-B-cell growth-stimulating factor
    thymic lymphoma cell-stimulating factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012477.2NP_001012495.1  stromal cell-derived factor 1 isoform gamma precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (gamma).
      Source sequence(s)
      AC155646, BC046827
      Consensus CDS
      CCDS20463.1
      UniProtKB/TrEMBL
      H7BX38
      Related
      ENSMUSP00000072800, OTTMUSP00000026114, ENSMUST00000073043, OTTMUST00000054664
      Conserved Domains (1) summary
      cd00273
      Location:2788
      Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...
    2. NM_013655.4NP_038683.1  stromal cell-derived factor 1 isoform beta precursor

      See identical proteins and their annotated locations for NP_038683.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 3. The resulting isoform (beta) is shorter and has a distinct C-terminus compared to isoform gamma.
      Source sequence(s)
      AC155646, BB840704
      Consensus CDS
      CCDS39605.1
      UniProtKB/Swiss-Prot
      P40224
      Related
      ENSMUSP00000108492, OTTMUSP00000026113, ENSMUST00000112871, OTTMUST00000054663
      Conserved Domains (1) summary
      cd00273
      Location:2788
      Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...
    3. NM_021704.3NP_068350.1  stromal cell-derived factor 1 isoform alpha precursor

      See identical proteins and their annotated locations for NP_068350.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 3' UTR and 3' coding region compared to variant 3. The resulting isoform (alpha) is shorter at the C-terminus, compared to isoform gamma.
      Source sequence(s)
      AC155646, AK045092
      Consensus CDS
      CCDS39606.1
      UniProtKB/Swiss-Prot
      P40224
      Related
      ENSMUSP00000108487, OTTMUSP00000026112, ENSMUST00000112866, OTTMUST00000054662
      Conserved Domains (1) summary
      cd00273
      Location:2788
      Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      117168535..117181368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)