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    Tnf tumor necrosis factor [ Mus musculus (house mouse) ]

    Gene ID: 21926, updated on 30-Jun-2015
    Official Symbol
    Tnfprovided by MGI
    Official Full Name
    tumor necrosis factorprovided by MGI
    Primary source
    MGI:MGI:104798
    See related
    Ensembl:ENSMUSG00000024401; Vega:OTTMUSG00000037196
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DIF; Tnfa; TNF-a; TNFSF2; Tnfsf1a; TNFalpha; TNF-alpha
    Summary
    This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure. This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions. It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation. In mouse deficiency of this gene is associated with defects in response to bacterial infection, with defects in forming organized follicular dendritic cell networks and germinal centers, and with a lack of primary B cell follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
    Orthologs
    Location:
    17 B1; 17 18.59 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (35199367..35202007, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (35336335..35338941, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene leukocyte specific transcript 1 Neighboring gene microRNA 6973a Neighboring gene lymphotoxin B Neighboring gene microRNA 6974 Neighboring gene lymphotoxin A Neighboring gene predicted gene, 32075

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC151434

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    tumor necrosis factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tumor necrosis factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tumor necrosis factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    tumor necrosis factor receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPKKK activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular extravasation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to amino acid stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    chronic inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    defense response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to Gram-positive bacterium IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    detection of mechanical stimulus involved in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    epithelial cell proliferation involved in salivary gland morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic apoptotic signaling pathway via death domain receptors IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    humoral immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukocyte migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
     
    lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organismal development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    necroptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    necroptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of L-glutamate transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of alkaline phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of branching involved in lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cytokine secretion involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of glucose import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of growth of symbiont in host IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein complex disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osteoclast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of NFAT protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of action potential ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcidiol 1-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of chemokine (C-X-C motif) ligand 2 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemokine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chronic inflammatory response to antigenic stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytokine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fever generation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of humoral immune response mediated by circulating immunoglobulin IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-gamma production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of interleukin-18 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-8 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of podosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein complex disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translational initiation by iron IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of vitamin D biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein import into nucleus, translocation ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    receptor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of branching involved in salivary gland morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of branching involved in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of immunoglobulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of reactive oxygen species metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
     
    response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    sequestering of triglyceride ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    transformed cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    transformed cell apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytic cup IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    tumor necrosis factor
    Names
    cachectin
    tumor necrosis factor ligand superfamily member 2
    tumor necrosis factor-alpha

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278601.1NP_001265530.1  tumor necrosis factor isoform 2

      See identical proteins and their annotated locations for NP_001265530.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
      Source sequence(s)
      BY167004, CR974444
      Consensus CDS
      CCDS70801.1
      UniProtKB/Swiss-Prot
      P06804
      Related
      ENSMUSP00000126122, OTTMUSP00000053530, ENSMUST00000167924, OTTMUST00000095889
      Conserved Domains (1) summary
      cd00184
      Location:86217
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    2. NM_013693.3NP_038721.1  tumor necrosis factor isoform 1

      See identical proteins and their annotated locations for NP_038721.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK153319, AK153800, CR974444
      Consensus CDS
      CCDS28691.1
      UniProtKB/Swiss-Prot
      P06804
      UniProtKB/TrEMBL
      Q3U593
      Related
      ENSMUSP00000025263, OTTMUSP00000053529, ENSMUST00000025263, OTTMUST00000095888
      Conserved Domains (1) summary
      cd00184
      Location:91233
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

      Range
      35199367..35202007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p3 129X1/SvJ

    Genomic

    1. NT_039662.3 Reference GRCm38.p3 129X1/SvJ

      Range
      1449052..1451692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p3 NOD/MrkTac

    Genomic

    1. NT_187027.1 Reference GRCm38.p3 NOD/MrkTac

      Range
      1517537..1520177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p3 NOD/ShiLtJ

    Genomic

    1. NT_187004.1 Reference GRCm38.p3 NOD/ShiLtJ

      Range
      1517774..1520414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000039.1 Alternate Mm_Celera

      Range
      38296067..38298710
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)