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    CXCL16 C-X-C motif chemokine ligand 16 [ Homo sapiens (human) ]

    Gene ID: 58191, updated on 14-Aug-2016
    Official Symbol
    CXCL16provided by HGNC
    Official Full Name
    C-X-C motif chemokine ligand 16provided by HGNC
    Primary source
    HGNC:HGNC:16642
    See related
    Ensembl:ENSG00000161921 HPRD:16103; MIM:605398; Vega:OTTHUMG00000090761
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SRPSOX; CXCLG16; SR-PSOX
    Orthologs
    Location:
    17p13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (4733529..4739928, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4636828..4643223, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101559451 Neighboring gene ribosomal protein S12 pseudogene 29 Neighboring gene arrestin beta 2 Neighboring gene mediator complex subunit 11 Neighboring gene zinc finger MYND-type containing 15 Neighboring gene transmembrane 4 L six family member 5

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of chemokine (C-X-C motif) ligand 16 (CXCL16) in human B cells PubMed
    Tat tat HIV-1 Tat protein significantly increases CXCL16 release in THP-1 macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    • Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
      Chemokine receptors bind chemokines, organism-specific biosystemChemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of i...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chemokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemokine activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    low-density lipoprotein receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    low-density lipoprotein receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    scavenger receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    chemotaxis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    receptor-mediated endocytosis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to cytokine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to interferon-gamma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    C-X-C motif chemokine 16
    Names
    CXC chemokine ligand 16
    chemokine (C-X-C motif) ligand 16
    scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
    small-inducible cytokine B16
    transmembrane chemokine CXCL16

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100812.1NP_001094282.1  C-X-C motif chemokine 16 precursor

      See identical proteins and their annotated locations for NP_001094282.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes a 3' terminal exon that extends past a splice site that is used in variant 1. This results in a novel 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AY358909, CA307348, DC373874
      Consensus CDS
      CCDS11052.1
      UniProtKB/Swiss-Prot
      Q9H2A7
      Related
      ENSP00000459592, OTTHUMP00000257981, ENST00000574412, OTTHUMT00000439577
    2. NM_022059.3NP_071342.2  C-X-C motif chemokine 16 precursor

      See identical proteins and their annotated locations for NP_071342.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF337812, AK315017, AW264069, AY358909
      Consensus CDS
      CCDS11052.1
      UniProtKB/Swiss-Prot
      Q9H2A7
      Related
      ENSP00000293778, OTTHUMP00000115953, ENST00000293778, OTTHUMT00000207506

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      4733529..4739928 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      4645555..4651953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)