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Prnp prion protein [ Mus musculus (house mouse) ]

Gene ID: 19122, updated on 19-Sep-2014
Official Symbol
Prnpprovided by MGI
Official Full Name
prion proteinprovided by MGI
Primary source
MGI:MGI:97769
Locus tag
RP23-401J24.1
See related
Ensembl:ENSMUSG00000079037; Vega:OTTMUSG00000014846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PrP; PrPC; Sinc; CD230; PrPSc; Prn-i; Prn-p; PrP<C>; AA960666; AI325101; prP27-30; prP33-35C
See Prnp in Epigenomics, MapViewer
Location:
2 F2; 2 64.07 cM
Exon count:
4
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 2 NC_000068.7 (131909928..131938436)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene endogenous retroviral sequence 3 Neighboring gene laminin receptor 1 (ribosomal protein SA), pseudogene 1 Neighboring gene prion protein gene complex Neighboring gene prion protein dublet Neighboring gene Ras association (RalGDS/AF-6) domain family member 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough Prn

Readthrough gene: Prn, Included gene: Prnd

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
chaperone binding ISO
Inferred from Sequence Orthology
more info
 
copper ion binding IDA
Inferred from Direct Assay
more info
PubMed 
copper ion binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tubulin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular copper ion homeostasis TAS
Traceable Author Statement
more info
PubMed 
learning or memory ISO
Inferred from Sequence Orthology
more info
 
negative regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of calcineurin-NFAT signaling cascade IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of interleukin-17 production IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of sequence-specific DNA binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 
nucleobase-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of potassium ion transmembrane transport IGI
Inferred from Genetic Interaction
more info
 
regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
response to copper ion ISO
Inferred from Sequence Orthology
more info
 
response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
cell TAS
Traceable Author Statement
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft TAS
Traceable Author Statement
more info
PubMed 
mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
major prion protein
Names
major prion protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278256.1NP_001265185.1  major prion protein precursor

    See proteins identical to NP_001265185.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK158908, AK159056, AV361844, CK622972
    Consensus CDS
    CCDS16766.1
    UniProtKB/Swiss-Prot
    P04925
    UniProtKB/TrEMBL
    Q4FJQ7
    Conserved Domains (2) summary
    smart00157
    Location:23241
    PRP; Major prion protein
    pfam11587
    Location:128
    Prion_bPrPp; Major prion protein bPrPp - N terminal
  2. NM_011170.3NP_035300.1  major prion protein precursor

    See proteins identical to NP_035300.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK148061, AK158908, AV361844, CK622972
    Consensus CDS
    CCDS16766.1
    UniProtKB/Swiss-Prot
    P04925
    UniProtKB/TrEMBL
    Q3UG89
    UniProtKB/TrEMBL
    Q4FJQ7
    Related
    ENSMUSP00000088833, OTTMUSP00000015760, ENSMUST00000091288, OTTMUST00000035259
    Conserved Domains (2) summary
    smart00157
    Location:23241
    PRP; Major prion protein
    pfam11587
    Location:128
    Prion_bPrPp; Major prion protein bPrPp - N terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000068.7 

    Range
    131909928..131938436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000024.1 

    Range
    133143177..133164084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)