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    Ubb ubiquitin B [ Mus musculus (house mouse) ]

    Gene ID: 22187, updated on 3-Jul-2016
    Official Symbol
    Ubbprovided by MGI
    Official Full Name
    ubiquitin Bprovided by MGI
    Primary source
    MGI:MGI:98888
    See related
    Ensembl:ENSMUSG00000019505 Vega:OTTMUSG00000005857
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ubc; Ubb2; Uba52; Rps27a; AL033289
    Summary
    This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of four direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Pseudogenes of this gene are located on chromosomes 3 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    11 B2; 11 38.46 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (62551171..62553213)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (62365006..62366714)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene centromere protein V Neighboring gene predicted gene 12279 Neighboring gene transient receptor potential cation channel, subfamily V, member 2 Neighboring gene RIKEN cDNA 2410006H16 gene Neighboring gene small nucleolar RNA, C/D box 49B

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fat pad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    female gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    female meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hypothalamus gonadotrophin-releasing hormone neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    seminiferous tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ubiquitin homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313984.1NP_001300913.1  polyubiquitin-B

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AI836769, AK007273, BY083861
      UniProtKB/Swiss-Prot
      P0CG49
      UniProtKB/TrEMBL
      Q78XY9
      Conserved Domains (2) summary
      cd01803
      Location:176
      Ubiquitin; Ubiquitin
      smart00213
      Location:172
      UBQ; Ubiquitin homologues
    2. NM_011664.4NP_035794.1  polyubiquitin-B

      See identical proteins and their annotated locations for NP_035794.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AI836769, AK007273, DV653535
      Consensus CDS
      CCDS24826.1
      UniProtKB/Swiss-Prot
      P0CG49
      UniProtKB/TrEMBL
      Q78XY9
      Related
      ENSMUSP00000019649, OTTMUSP00000006062, ENSMUST00000019649, OTTMUST00000013034
      Conserved Domains (2) summary
      cd01803
      Location:176
      Ubiquitin; Ubiquitin
      smart00213
      Location:172
      UBQ; Ubiquitin homologues

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      62551171..62553213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)