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    Aqp2 aquaporin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25386, updated on 23-Aug-2016
    Official Symbol
    Aqp2provided by RGD
    Official Full Name
    aquaporin 2provided by RGD
    Primary source
    RGD:2142
    See related
    Ensembl:ENSRNOG00000054378
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AQP-2; aquaporin-2
    Summary
    water channel protein involved in water reabsorption and vasopressin regulation in kidney collecting duct cells; mutation is linked to nephrogenic diabetes insipidous (NDI) [RGD, Feb 2006]
    Orthologs
    Location:
    chromosome: 7
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (141237802..141242837)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) X NC_005120.3 (115742312..115747347)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene BCDIN3 domain containing RNA methyltransferase Neighboring gene Fas apoptotic inhibitory molecule 2 Neighboring gene aquaporin 5 Neighboring gene aquaporin 6

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC156502

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycerol channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    glycerol transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    glycerol transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    porin activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    water channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    water channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    water channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    water transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    water transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell volume homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to copper ion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to copper ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to mercury ion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to mercury ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to water deprivation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to water deprivation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to water deprivation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular water homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    glycerol transport IEA
    Inferred from Electronic Annotation
    more info
     
    glycerol transport ISO
    Inferred from Sequence Orthology
    more info
     
    hyperosmotic response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    metanephric collecting duct development IEA
    Inferred from Electronic Annotation
    more info
     
    metanephric collecting duct development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renal water transport IEA
    Inferred from Electronic Annotation
    more info
     
    renal water transport ISO
    Inferred from Sequence Orthology
    more info
     
    response to calcium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucagon IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lithium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to salt stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to starvation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    water homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    water transport IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    water transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    water transport ISO
    Inferred from Sequence Orthology
    more info
     
    water transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    exocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    pore complex IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    recycling endosome IEA
    Inferred from Electronic Annotation
    more info
     
    recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transport vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    aquaporin-2
    Names
    ADH water channel
    AQP-CD
    WCH-CD
    aquaporin 2 (collecting duct)
    aquaporin-CD
    collecting duct water channel protein
    water channel protein for renal collecting duct

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012909.2NP_037041.2  aquaporin-2

      See identical proteins and their annotated locations for NP_037041.2

      Status: PROVISIONAL

      Source sequence(s)
      D13906
      UniProtKB/Swiss-Prot
      P34080
      Related
      ENSRNOP00000074297, ENSRNOT00000091717
      Conserved Domains (1) summary
      pfam00230
      Location:3219
      MIP; Major intrinsic protein

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      141237802..141242837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000075.1 Alternate Rn_Celera

      Range
      127193026..127197996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)