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    EIF5A eukaryotic translation initiation factor 5A [ Homo sapiens (human) ]

    Gene ID: 1984, updated on 26-Jul-2015
    Official Symbol
    EIF5Aprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 5Aprovided by HGNC
    Primary source
    HGNC:HGNC:3300
    See related
    Ensembl:ENSG00000132507; HPRD:02555; MIM:600187; Vega:OTTHUMG00000102197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EIF-5A; EIF5A1; eIF5AI
    Orthologs
    See EIF5A in Epigenomics, MapViewer
    Location:
    17p13-p12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (7306999..7312463)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7210318..7215782)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 4 Neighboring gene Y box binding protein 2 Neighboring gene uncharacterized LOC105371513 Neighboring gene G protein pathway suppressor 2 Neighboring gene neuralized E3 ubiquitin protein ligase 4

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev eIF-5A binds Rev Response Element (RRE) RNA, an interaction likely to be involved in its association with Rev during nuclear export PubMed
    rev eIF-5A directly interacts with CRM1 and mediates its binding to Rev, an effect that is required for nuclear export of Rev PubMed
    rev eIF-5A is a hypusine-containing protein required for Rev-mediated nuclear export of HIV-1 mRNA PubMed
    rev eIF-5A interacts with the ribosomal protein L5 during its Rev nuclear export activity PubMed
    rev eIF-5A interacts with nucleoporins CAN/nup214, nup153, nup98, and nup62 as well as nuclear actin during the nuclear export of Rev PubMed
    rev eIF-5A interacts with the activation domain of Rev (amino acids 75-83) PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human eukaryotic translation initiation factor 5A (EIF5A) at amino acid residues 5-6, 96-97, 97-98, and 100-101 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    • Gamma carboxylation, hypusine formation and arylsulfatase activation, organism-specific biosystem (from REACTOME)
      Gamma carboxylation, hypusine formation and arylsulfatase activation, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Hypusine synthesis from eIF5A-lysine, organism-specific biosystem (from REACTOME)
      Hypusine synthesis from eIF5A-lysine, organism-specific biosystemCytosolic eIF5A undergoes a unique two-step post-translational modification at Lys 50 via deoxyhypusine (Dhp) to hypusine (Hyp). In the first step deoxyhypusine synthase transfers the aminobutyl grou...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Translation Factors, organism-specific biosystem (from WikiPathways)
      Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC99547, MGC104255

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    U6 snRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ribosome binding IEA
    Inferred from Electronic Annotation
    more info
     
    translation elongation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT nucleocytoplasmic transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleocytoplasmic transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-lysine modification to peptidyl-hypusine TAS
    Traceable Author Statement
    more info
     
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of translational elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of translational termination IEA
    Inferred from Electronic Annotation
    more info
     
    post-translational protein modification TAS
    Traceable Author Statement
    more info
     
    protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    translational frameshifting IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    annulate lamellae IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear pore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    eukaryotic translation initiation factor 5A-1
    Names
    eIF-4D
    eIF-5A-1
    eIF-5A1
    eukaryotic initiation factor 5A
    rev-binding factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143760.1NP_001137232.1  eukaryotic translation initiation factor 5A-1 isoform A

      See identical proteins and their annotated locations for NP_001137232.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) encodes the longer isoform (A).
      Source sequence(s)
      AC026954, AY129319
      Consensus CDS
      CCDS45601.1
      UniProtKB/Swiss-Prot
      P63241
      Related
      ENSP00000336702, OTTHUMP00000258505, ENST00000336452, OTTHUMT00000440513
      Conserved Domains (2) summary
      PLN03107
      Location:31180
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
      cd04468
      Location:114182
      S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...
    2. NM_001143761.1NP_001137233.1  eukaryotic translation initiation factor 5A-1 isoform B

      See identical proteins and their annotated locations for NP_001137233.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (C) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant A. The encoded isoform (B) has a shorter N-terminus compared to isoform A. Variants B, C, and D encode the same isoform.
      Source sequence(s)
      AC026954, AY129321
      Consensus CDS
      CCDS11099.1
      UniProtKB/Swiss-Prot
      P63241
      Related
      ENSP00000390677, OTTHUMP00000258515, ENST00000419711, OTTHUMT00000440537
      Conserved Domains (2) summary
      PLN03107
      Location:1150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
      cd04468
      Location:84152
      S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...
    3. NM_001143762.1NP_001137234.1  eukaryotic translation initiation factor 5A-1 isoform B

      See identical proteins and their annotated locations for NP_001137234.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (D) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant A. The encoded isoform (B) has a shorter N-terminus compared to isoform A. Variants B, C, and D encode the same isoform.
      Source sequence(s)
      AC026954, AY129322, BG479628
      Consensus CDS
      CCDS11099.1
      UniProtKB/Swiss-Prot
      P63241
      Related
      ENSP00000396073, OTTHUMP00000258517, ENST00000416016, OTTHUMT00000440539
      Conserved Domains (2) summary
      PLN03107
      Location:1150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
      cd04468
      Location:84152
      S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...
    4. NM_001970.4NP_001961.1  eukaryotic translation initiation factor 5A-1 isoform B

      See identical proteins and their annotated locations for NP_001961.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant A. The encoded isoform (B) has a shorter N-terminus compared to isoform A. Variants B, C, and D encode the same isoform.
      Source sequence(s)
      AC026954, AY129320, CB111036
      Consensus CDS
      CCDS11099.1
      UniProtKB/Swiss-Prot
      P63241
      Related
      ENSP00000336776, OTTHUMP00000128384, ENST00000336458, OTTHUMT00000220047
      Conserved Domains (2) summary
      PLN03107
      Location:1150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
      cd04468
      Location:84152
      S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

      Range
      7306999..7312463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011523709.1XP_011522011.1  

      See identical proteins and their annotated locations for XP_011522011.1

    2. XM_011523708.1XP_011522010.1  

    3. XM_011523712.1XP_011522014.1  

      See identical proteins and their annotated locations for XP_011522014.1

    4. XM_011523710.1XP_011522012.1  

      See identical proteins and their annotated locations for XP_011522012.1

    5. XM_005256509.1XP_005256566.1  

      See identical proteins and their annotated locations for XP_005256566.1

      UniProtKB/Swiss-Prot
      P63241
      Conserved Domains (2) summary
      PLN03107
      Location:1150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
      cd04468
      Location:84152
      S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...
    6. XM_011523711.1XP_011522013.1  

      See identical proteins and their annotated locations for XP_011522013.1

    7. XM_011523713.1XP_011522015.1  

      See identical proteins and their annotated locations for XP_011522015.1

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      7219093..7224550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)