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Mif macrophage migration inhibitory factor [ Mus musculus (house mouse) ]

Gene ID: 17319, updated on 20-Feb-2015
Official Symbol
Mifprovided by MGI
Official Full Name
macrophage migration inhibitory factorprovided by MGI
Primary source
MGI:MGI:96982
See related
Ensembl:ENSMUSG00000033307
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GIF; Glif
Orthologs
See Mif in MapViewer
Location:
10 38.59 cM; 10 C1
Exon count:
3
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (75859353..75860250, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase, theta 4 Neighboring gene glutathione S-transferase, theta 2 Neighboring gene uncharacterized LOC105245213 Neighboring gene Der1-like domain family, member 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC107654

Gene Ontology Provided by MGI

Function Evidence Code Pubs
chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity ISO
Inferred from Sequence Orthology
more info
 
cytokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
dopachrome isomerase activity ISO
Inferred from Sequence Orthology
more info
 
isomerase activity IEA
Inferred from Electronic Annotation
more info
 
phenylpyruvate tautomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
phenylpyruvate tautomerase activity ISO
Inferred from Sequence Orthology
more info
 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain renin-angiotensin system ISO
Inferred from Sequence Orthology
more info
 
carboxylic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
drinking behavior ISO
Inferred from Sequence Orthology
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell aging ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cellular protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mature B cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of myeloid cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of adaptive immune response NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of arachidonic acid secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of axon regeneration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chemokine (C-X-C motif) ligand 2 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytokine secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of immune response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of myeloid leukocyte cytokine production involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of prostaglandin secretion involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
protein homotrimerization ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
intracellular IMP
Inferred from Mutant Phenotype
more info
PubMed 
myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
vesicle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
macrophage migration inhibitory factor
Names
macrophage migration inhibitory factor
DER6
L-dopachrome isomerase
L-dopachrome tautomerase
delayed early response protein 6
glycosylation-inhibiting factor
phenylpyruvate tautomerase
NP_034928.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010798.2NP_034928.1  macrophage migration inhibitory factor

    See proteins identical to NP_034928.1

    Status: PROVISIONAL

    Source sequence(s)
    AC142499
    Consensus CDS
    CCDS23934.1
    UniProtKB/Swiss-Prot
    P34884
    UniProtKB/TrEMBL
    Q545F0
    Related
    ENSMUSP00000041149, ENSMUST00000038169
    Conserved Domains (1) summary
    pfam01187
    Location:2115
    MIF; Macrophage migration inhibitory factor (MIF)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

    Range
    75859353..75860250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000032.1 Alternate Mm_Celera

    Range
    76904043..76904940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)