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DYN1 dynein heavy chain [ Saccharomyces cerevisiae S288c ]

Gene ID: 853928, updated on 3-Aug-2014
Gene symbol
DYN1
Gene description
dynein heavy chain
Primary source
SGD:S000001762
Locus tag
YKR054C
Gene type
protein coding
RNA name
dynein heavy chain
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DHC1; PAC6
See DYN1 in MapViewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (535647..547925, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mrs4p Neighboring gene sphinganine kinase YSR3 Neighboring gene Rho4p Neighboring gene Trm2p

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
microtubule motor activity IDA
Inferred from Direct Assay
more info
PubMed 
microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
motor activity IEA
Inferred from Electronic Annotation
more info
 
nucleoside-triphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ATP catabolic process IEA
Inferred from Electronic Annotation
more info
 
establishment of mitotic spindle localization IMP
Inferred from Mutant Phenotype
more info
 
establishment of mitotic spindle orientation IGI
Inferred from Genetic Interaction
more info
PubMed 
establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
karyogamy IEA
Inferred from Electronic Annotation
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
mitotic sister chromatid segregation IGI
Inferred from Genetic Interaction
more info
PubMed 
nuclear migration along microtubule IGI
Inferred from Genetic Interaction
more info
PubMed 
nuclear migration along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
astral microtubule IDA
Inferred from Direct Assay
more info
PubMed 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic dynein complex IPI
Inferred from Physical Interaction
more info
PubMed 
cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
dynein complex IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
spindle pole body IDA
Inferred from Direct Assay
more info
PubMed 
Names
dynein heavy chain
NP_012980.1
  • Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 

    Range
    535647..547925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179844.1NP_012980.1  dynein heavy chain [Saccharomyces cerevisiae S288c]

    See proteins identical to NP_012980.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P36022
    Conserved Domains (9) summary
    cd00009
    Location:23932561
    Blast Score: 164
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam12777
    Location:30143346
    Blast Score: 270
    MT; Microtubule-binding stalk of dynein motor
    pfam12780
    Location:27322954
    Blast Score: 264
    AAA_8; P-loop containing dynein motor region D4
    pfam12781
    Location:33793598
    Blast Score: 261
    AAA_9; ATP-binding dynein motor region D5
    COG5245
    Location:7744083
    Blast Score: 11911
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam03028
    Location:37944003
    Blast Score: 267
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:215763
    Blast Score: 991
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:12241631
    Blast Score: 785
    DHC_N2; Dynein heavy chain, N-terminal region 2
    cl18944
    Location:17581977
    Blast Score: 508
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...