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SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) [ Homo sapiens (human) ]

Gene ID: 7356, updated on 7-Dec-2014
Official Symbol
SCGB1A1provided by HGNC
Official Full Name
secretoglobin, family 1A, member 1 (uteroglobin)provided by HGNC
Primary source
HGNC:HGNC:12523
See related
Ensembl:ENSG00000149021; HPRD:01884; MIM:192020; Vega:OTTHUMG00000167526
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UGB; UP1; CC10; CC16; CCSP; UP-1; CCPBP
Summary
This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]
See SCGB1A1 in Epigenomics, MapViewer
Location:
11q12.3
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (62419035..62423206)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62186507..62190678)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene asparaginase like 1 Neighboring gene regulator of chromosome condensation 2 pseudogene 6 Neighboring gene uncharacterized LOC102723765 Neighboring gene uncharacterized LOC101929364 Neighboring gene AHNAK nucleoprotein Neighboring gene uncharacterized LOC101927617

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phospholipase A2 inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
embryo implantation TAS
Traceable Author Statement
more info
PubMed 
female pregnancy NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interferon-gamma production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-13 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-4 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-5 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
regulation of mRNA stability IEA
Inferred from Electronic Annotation
more info
 
response to cytokine IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to fibroblast growth factor IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to ozone IEA
Inferred from Electronic Annotation
more info
 
response to silicon dioxide IEA
Inferred from Electronic Annotation
more info
 
response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
secretory granule IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
uteroglobin
Names
uteroglobin
blastokinin
urine protein 1
urinary protein 1
clara cells 10 kDa secretory protein
clara cell phospholipid-binding protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021331.1 

    Range
    5001..9172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003357.4NP_003348.1  uteroglobin precursor

    See proteins identical to NP_003348.1

    Status: REVIEWED

    Source sequence(s)
    AK312165, AP003064, BC004481, DB196705
    Consensus CDS
    CCDS8020.1
    UniProtKB/Swiss-Prot
    P11684
    Related
    ENSP00000278282, OTTHUMP00000236107, ENST00000278282, OTTHUMT00000394925
    Conserved Domains (1) summary
    cd00633
    Location:2490
    Secretoglobin; Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with encoding genes sharing substantial sequence similarity. Their family subunits may be grouped into five subfamilies, A-E. Uteroglobin (subfamily A), which is identical ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    62419035..62423206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    62069549..62073720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    58514572..58518782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)