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Mecp2 methyl CpG binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 17257, updated on 23-Jul-2014
Official Symbol
Mecp2provided by MGI
Official Full Name
methyl CpG binding protein 2provided by MGI
Primary source
MGI:99918
Locus tag
RP23-252M19.8
See related
Ensembl:ENSMUSG00000031393; Vega:OTTMUSG00000017654
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mbd5; WBP10; 1500041B07Rik; D630021H01Rik
See Mecp2 in Epigenomics, MapViewer
Location:
X A7.3; X 37.63 cM
Exon count:
5
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) X NC_000086.7 (74026592..74085636, complement)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene interleukin-1 receptor-associated kinase 1 Neighboring gene microRNA 5132 Neighboring gene microRNA 718 Neighboring gene opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan) Neighboring gene heterogeneous nuclear ribonucleoprotein A3-like Neighboring gene testis expressed 28 Neighboring gene ribosomal protein L3, pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded methylated DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded methylated DNA binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded methylated DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
four-way junction DNA binding ISO
Inferred from Sequence Orthology
more info
 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
methyl-CpG binding IDA
Inferred from Direct Assay
more info
PubMed 
methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
siRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
unmethylated CpG binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiolipin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
catecholamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular biogenic amine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucocorticoid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
inositol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial electron transport, ubiquinol to cytochrome c IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organismal response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of histone acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of histone methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
neurological system process involved in regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuromuscular process IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuromuscular process controlling posture IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
pathogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylcholine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
proprioception IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of excitatory postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene expression by genetic imprinting IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of respiratory gaseous exchange by neurological system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
respiratory gaseous exchange IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
startle response IMP
Inferred from Mutant Phenotype
more info
PubMed 
synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
ventricular system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
heterochromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
methyl-CpG-binding protein 2
Names
methyl-CpG-binding protein 2
meCp-2 protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081979.2NP_001075448.1  methyl-CpG-binding protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK158664, AL672002, BU700810
    Consensus CDS
    CCDS41016.1
    UniProtKB/Swiss-Prot
    Q9Z2D6
    Conserved Domains (1) summary
    cd01396
    Location:111185
    Blast Score: 240
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
  2. NM_010788.4NP_034918.1  methyl-CpG-binding protein 2 isoform 2

    See proteins identical to NP_034918.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and contains an alternate exon resulting in the use of an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL672002, BU700810
    Consensus CDS
    CCDS41017.1
    UniProtKB/Swiss-Prot
    Q9Z2D6
    Related
    ENSMUSP00000098314, OTTMUSP00000019241, ENSMUST00000100750, OTTMUST00000042852
    Conserved Domains (1) summary
    cd01396
    Location:94168
    Blast Score: 242
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000086.7 

    Range
    74026592..74085636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527888.1XP_006527951.1  

    See proteins identical to XP_006527951.1

    UniProtKB/Swiss-Prot
    Q9Z2D6
    Conserved Domains (1) summary
    cd01396
    Location:94168
    Blast Score: 242
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...

Alternate Mm_Celera

Genomic

  1. AC_000042.1 

    Range
    65279211..65338021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)