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    PLK2 polo like kinase 2 [ Homo sapiens (human) ]

    Gene ID: 10769, updated on 22-Sep-2016
    Official Symbol
    PLK2provided by HGNC
    Official Full Name
    polo like kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:19699
    See related
    Ensembl:ENSG00000145632 HPRD:06118; MIM:607023; Vega:OTTHUMG00000097047
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SNK; hSNK; hPlk2
    Summary
    The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
    Orthologs
    Location:
    5q12.1-q13.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (58453982..58460139, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (57749809..57755966, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378983 Neighboring gene uncharacterized LOC105378984 Neighboring gene GRB2 binding adaptor protein, transmembrane Neighboring gene microRNA 548ae-2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    signal transducer activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
    Traceable Author Statement
    more info
     
    G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Rap protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    long term synaptic depression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    long-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    memory ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitotic cell cycle checkpoint ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitotic spindle organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of dendritic spine development IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of centriole replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    serine/threonine-protein kinase PLK2
    Names
    PLK-2
    serine/threonine-protein kinase SNK
    serum-inducible kinase
    NP_001239155.1
    NP_006613.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252226.1NP_001239155.1  serine/threonine-protein kinase PLK2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is alternatively spliced in the 5' region compared to variant 1, however, it maintains the reading frame and encodes a shorter isoform (2) missing a 14 aa protein segment compared to isoform 1.
      Source sequence(s)
      AA954432, AK027851, BC013879, BI559351, N66865
      Consensus CDS
      CCDS75250.1
      UniProtKB/Swiss-Prot
      Q9NYY3
      UniProtKB/TrEMBL
      A0A087WUH9
      Related
      ENSP00000478685, ENST00000617412
      Conserved Domains (4) summary
      smart00220
      Location:68320
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13117
      Location:587668
      POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd13118
      Location:489574
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd14188
      Location:66320
      STKc_PLK2; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2
    2. NM_006622.3NP_006613.2  serine/threonine-protein kinase PLK2 isoform 1

      See identical proteins and their annotated locations for NP_006613.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).
      Source sequence(s)
      AA954432, AK027851, BC013879, BI559351, N66865
      Consensus CDS
      CCDS3974.1
      UniProtKB/Swiss-Prot
      Q9NYY3
      UniProtKB/TrEMBL
      A0A024QZV1
      Related
      ENSP00000274289, OTTHUMP00000122549, ENST00000274289, OTTHUMT00000214150
      Conserved Domains (4) summary
      smart00220
      Location:82334
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13117
      Location:601682
      POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd13118
      Location:503588
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd14188
      Location:80334
      STKc_PLK2; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      58453982..58460139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      57749420..57755577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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