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    Apc adenomatosis polyposis coli [ Mus musculus (house mouse) ]

    Gene ID: 11789, updated on 26-Jul-2016
    Official Symbol
    Apcprovided by MGI
    Official Full Name
    adenomatosis polyposis coliprovided by MGI
    Primary source
    MGI:MGI:88039
    See related
    Ensembl:ENSMUSG00000005871 Vega:OTTMUSG00000035932
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CC1; Min; mAPC; AI047805; AU020952; AW124434
    Orthologs
    Location:
    18 B1; 18 18.53 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (34220617..34322190)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (34380638..34481844)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene chr18_319.1 Neighboring gene predicted gene, 41687 Neighboring gene predicted gene, 41686 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene signal recognition particle 19 Neighboring gene receptor accessory protein 5

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    gamma-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    gamma-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
     
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway involved in negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    canonical Wnt signaling pathway involved in positive regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoplasmic microtubule organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment or maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metaphase/anaphase transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    metaphase/anaphase transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    muscle cell cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of epithelial cell proliferation involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of odontogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    pattern specification process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pseudopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    proximal/distal pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of glutamate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of nitrogen compound metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somatic stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thymus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Scrib-APC-beta-catenin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axonal growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin destruction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    beta-catenin destruction complex ISO
    Inferred from Sequence Orthology
    more info
     
    bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    catenin complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell body fiber ISO
    Inferred from Sequence Orthology
    more info
     
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cell-cell adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with synapse ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    adenomatous polyposis coli protein
    Names
    multiple intestinal neoplasia

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007462.3NP_031488.2  adenomatous polyposis coli protein

      See identical proteins and their annotated locations for NP_031488.2

      Status: VALIDATED

      Source sequence(s)
      AC090534, AK080907, AL591373, BE623286
      Consensus CDS
      CCDS29125.1
      UniProtKB/TrEMBL
      B2RUG9, Q8BNP7
      Related
      ENSMUSP00000078337, OTTMUSP00000051004, ENSMUST00000079362, OTTMUST00000092329
      Conserved Domains (14) summary
      cd00020
      Location:609729
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:16351659
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20332052
      SAMP; SAMP Motif
      pfam05937
      Location:26702842
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22232568
      APC_basic; APC basic domain
      pfam11414
      Location:125205
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:7301017
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10341133
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12811367
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16601716
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17371837
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18741945
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      sd00043
      Location:463506
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      34220617..34322190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525529.3XP_006525592.1  

      Conserved Domains (6) summary
      pfam05937
      Location:26982870
      EB1_binding; EB-1 Binding Domain
      pfam05923
      Location:16621687
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20612080
      SAMP; SAMP Motif
      pfam11414
      Location:134216
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      cd00020
      Location:637757
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05956
      Location:22512596
      APC_basic; APC basic domain
    2. XM_006525534.3XP_006525597.1  

      Conserved Domains (6) summary
      pfam05937
      Location:26632835
      EB1_binding; EB-1 Binding Domain
      pfam05923
      Location:16271652
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20262045
      SAMP; SAMP Motif
      pfam11414
      Location:134216
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      cd00020
      Location:602722
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05956
      Location:22162561
      APC_basic; APC basic domain
    3. XM_006525532.3XP_006525595.1  

      See identical proteins and their annotated locations for XP_006525595.1

      Conserved Domains (6) summary
      pfam05937
      Location:26802852
      EB1_binding; EB-1 Binding Domain
      pfam05923
      Location:16441669
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20432062
      SAMP; SAMP Motif
      pfam11414
      Location:134216
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      cd00020
      Location:619739
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05956
      Location:22332578
      APC_basic; APC basic domain
    4. XM_006525538.3XP_006525601.1  

      Conserved Domains (6) summary
      pfam05937
      Location:25972769
      EB1_binding; EB-1 Binding Domain
      pfam05923
      Location:15611586
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:19601979
      SAMP; SAMP Motif
      pfam11414
      Location:134216
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      cd00020
      Location:536656
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05956
      Location:21502495
      APC_basic; APC basic domain
    5. XM_006525530.1XP_006525593.1  

      See identical proteins and their annotated locations for XP_006525593.1

      Conserved Domains (6) summary
      pfam05937
      Location:26882860
      EB1_binding; EB-1 Binding Domain
      pfam05923
      Location:16521677
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20512070
      SAMP; SAMP Motif
      pfam11414
      Location:124206
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      cd00020
      Location:627747
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05956
      Location:22412586
      APC_basic; APC basic domain
    6. XM_006525539.2XP_006525602.1  

      Conserved Domains (6) summary
      pfam05937
      Location:25692741
      EB1_binding; EB-1 Binding Domain
      pfam05923
      Location:15331558
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:19321951
      SAMP; SAMP Motif
      pfam11414
      Location:124206
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      cd00020
      Location:508628
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05956
      Location:21222467
      APC_basic; APC basic domain
    7. XM_006525533.2XP_006525596.1  

      Conserved Domains (6) summary
      pfam05937
      Location:26682840
      EB1_binding; EB-1 Binding Domain
      pfam05923
      Location:16321657
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20312050
      SAMP; SAMP Motif
      pfam11414
      Location:104186
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      cd00020
      Location:607727
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05956
      Location:22212566
      APC_basic; APC basic domain
    8. XM_006525536.3XP_006525599.1  

      See identical proteins and their annotated locations for XP_006525599.1

      Conserved Domains (6) summary
      pfam05937
      Location:26292801
      EB1_binding; EB-1 Binding Domain
      pfam05923
      Location:15931618
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:19922011
      SAMP; SAMP Motif
      pfam11414
      Location:65147
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      cd00020
      Location:568688
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05956
      Location:21822527
      APC_basic; APC basic domain
    9. XM_017317804.1XP_017173293.1  

    10. XM_006525531.1XP_006525594.1  

      See identical proteins and their annotated locations for XP_006525594.1

      Conserved Domains (6) summary
      pfam05937
      Location:26882860
      EB1_binding; EB-1 Binding Domain
      pfam05923
      Location:16521677
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20512070
      SAMP; SAMP Motif
      pfam11414
      Location:124206
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      cd00020
      Location:627747
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05956
      Location:22412586
      APC_basic; APC basic domain
    11. XM_006525535.1XP_006525598.1  

      See identical proteins and their annotated locations for XP_006525598.1

      Conserved Domains (6) summary
      pfam05937
      Location:26292801
      EB1_binding; EB-1 Binding Domain
      pfam05923
      Location:15931618
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:19922011
      SAMP; SAMP Motif
      pfam11414
      Location:65147
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      cd00020
      Location:568688
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05956
      Location:21822527
      APC_basic; APC basic domain