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    ERP29 endoplasmic reticulum protein 29 [ Homo sapiens (human) ]

    Gene ID: 10961, updated on 23-Jul-2015
    Official Symbol
    ERP29provided by HGNC
    Official Full Name
    endoplasmic reticulum protein 29provided by HGNC
    Primary source
    HGNC:HGNC:13799
    See related
    Ensembl:ENSG00000089248; HPRD:03794; MIM:602287; Vega:OTTHUMG00000169637
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERp28; ERp31; PDIA9; PDI-DB; C12orf8; HEL-S-107
    Summary
    This gene encodes a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum (ER). The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Orthologs
    See ERP29 in Epigenomics, MapViewer
    Location:
    12q24.13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (112013348..112023220)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (112451152..112461024)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 116 Neighboring gene solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 pseudogene 2 Neighboring gene immediate early response 3 interacting protein 1 pseudogene Neighboring gene N(alpha)-acetyltransferase 25, NatB auxiliary subunit Neighboring gene microRNA 3657 Neighboring gene TRAF-type zinc finger domain containing 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chaperone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT protein disulfide isomerase activity IKR
    Inferred from Key Residues
    more info
    PubMed 
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    activation of MAPK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular protein transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein folding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein secretion IEA
    Inferred from Electronic Annotation
    more info
     
    protein unfolding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum lumen NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    smooth endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transport vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    endoplasmic reticulum resident protein 29
    Names
    endoplasmic reticulum lumenal protein ERp28
    endoplasmic reticulum resident protein 28
    endoplasmic reticulum resident protein 31
    epididymis secretory protein Li 107
    protein disulfide isomerase family A, member 9

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034025.1NP_001029197.1  endoplasmic reticulum resident protein 29 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the coding region that results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA412124, AC073575
      Consensus CDS
      CCDS44977.1
      UniProtKB/Swiss-Prot
      P30040
      Related
      ENSP00000412083, OTTHUMP00000241752, ENST00000455836, OTTHUMT00000405201
      Conserved Domains (1) summary
      cl00388
      Location:3350
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    2. NM_006817.3NP_006808.1  endoplasmic reticulum resident protein 29 isoform 1 precursor

      See identical proteins and their annotated locations for NP_006808.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA412124, AC073575, BC101493
      Consensus CDS
      CCDS9158.1
      UniProtKB/Swiss-Prot
      P30040
      UniProtKB/TrEMBL
      V9HW71
      Related
      ENSP00000261735, OTTHUMP00000241751, ENST00000261735, OTTHUMT00000405200
      Conserved Domains (2) summary
      cd00238
      Location:158251
      ERp29c; ERp29 and ERp38, C-terminal domain; composed of the protein disulfide isomerase (PDI)-like proteins ERp29 and ERp38. ERp29 (also called ERp28) is a ubiquitous endoplasmic reticulum (ER)-resident protein expressed in high levels in secretory cells. It ...
      cd03007
      Location:36149
      PDI_a_ERp29_N; PDIa family, endoplasmic reticulum protein 29 (ERp29) subfamily; ERp29 is a ubiquitous ER-resident protein expressed in high levels in secretory cells. It forms homodimers and higher oligomers in vitro and in vivo. It contains a redox inactive TRX-like ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

      Range
      112013348..112023220
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      112419401..112429273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)