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CXCL8 chemokine (C-X-C motif) ligand 8 [ Homo sapiens (human) ]

Gene ID: 3576, updated on 18-Jan-2015
Official Symbol
CXCL8provided by HGNC
Official Full Name
chemokine (C-X-C motif) ligand 8provided by HGNC
Primary source
HGNC:HGNC:6025
See related
Ensembl:ENSG00000169429; HPRD:00909; MIM:146930; Vega:OTTHUMG00000151316
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1
Summary
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]
Orthologs
See CXCL8 in MapViewer
Location:
4q13-q21
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 4 NC_000004.12 (73740506..73743716)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (74606223..74609433)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene hCG1813624 Neighboring gene Ras association (RalGDS/AF-6) domain family member 6 Neighboring gene chemokine (C-X-C motif) ligand 6 Neighboring gene pro-platelet basic protein pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of interleukin 8 (IL8) in human B cells PubMed
env HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes PubMed
env The binding of soluble HIV-1 gp120 to TLR2 or TLR4 results in upregulation of the TNF-alpha and IL-8 production through NF-kappaB activation PubMed
env In endometrial epithelium-derived cells, gp120 from CCR5-tropic HIV-1 increases the release of monocytes/chemokines-attracting chemokines (IL-8 and GRO) and proinflammatory cytokines (TNF-beta and IL-1alpha) PubMed
env HIV-1 gp120-mediated increases in IL-8 production in astrocytes are mediated through the NF-KappaB pathway PubMed
env Interleukin 8 (IL-8) gene expression is enhanced in monocytes treated with HIV-1 gp120 PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 inhibits activation of PBMCs and upregulates the expression of IL-8 in peptide-treated PBMCs PubMed
env The interaction between HIV-1 gp41 fusion peptide and lymphocyte membrane is blocked by interleukin-8 and abolished by pre-treating the cells with heparin sulfate (HS) PubMed
Nef nef HIV-1 Nef expression by immature human and macaque dendritic cells (DCs) upregulates IL-6, IL-12, TNF-alpha, CXCL8, CCL3, and CCL4 release, but without upregulating co-stimulatory and other molecules characteristic of mature DCs PubMed
Tat tat HIV-1 Tat upregulates IL-8 expression in astrocytes, monocytes, monocyte derived macrophages, Jurkat T-cells, HeLa cells, and human brain endothelial cells, an effect that likely contributes to the immune dysregulation observed during HIV-1 infection PubMed
tat HIV-1 Tat downregulates the expression of adiponectin protein and upregulates the expression of IL-6, IL-8, and MCP-1 proteins in human SGBS preadipocytes PubMed
tat HIV-1 Tat upregulation of IL-8 is linked to the cell cycle and involves NF-kappa B, RelA, c-rel, and CREB-binding protein PubMed
tat Upregulation of IL-8 by HIV-1 Tat in astrocytes is inhibited by the MEK1/2 inhibitor UO126, indicating a role for MEK1/2 in Tat-mediated chemokine induction PubMed
tat HIV-1 Tat protein upregulates expression of IL-6 and IL-8 in human breast cancer cells by an NF-kappaB-dependent pathway PubMed
tat HIV-1 Tat upregulates IL-8 and VEGF production and release from polymorphonuclear leukocytes (PMNL), indicating that PMNL recruitment by Tat is linked to angiogenesis PubMed
tat Upregulation of IL-8 by HIV-1 Tat is implicated in the pathogenesis of Kaposi's sarcoma PubMed
tat HIV-1 Tat downregulates IL-8 expression in the Raji B-cell line, however in the presence of PMA+PHA Tat induced IL-8 expression PubMed
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL-6, IL-8, MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1) PubMed
vpr HIV-1 Vpr regulates interleukin 8 (IL-8) expression, with reports showing both up- and downregulation of IL-8 PubMed
integrase gag-pol IL-8 decreases HIV-1 reverse transcription and viral integration during the early infection, suggesting the interaction between HIV-1 IN and IL-8 PubMed
matrix gag Surface plasmon resonance analysis reveals that HIV-1 p17 binds IL-8 PubMed
nucleocapsid gag HIV-1 NC upregulates IL8 in HEK 293T cells PubMed
reverse transcriptase gag-pol IL-8 decreases HIV-1 reverse transcription and viral integration during the early infection, suggesting the interaction between HIV-1 RT and IL-8 PubMed

Go to the HIV-1, Human Interaction Database

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  • Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
    Glucocorticoid receptor regulatory network, organism-specific biosystem
    Glucocorticoid receptor regulatory network
  • Hepatitis B, organism-specific biosystem (from KEGG)
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  • Hepatitis C, organism-specific biosystem (from KEGG)
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  • Hepatitis C, conserved biosystem (from KEGG)
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  • Influenza A, organism-specific biosystem (from KEGG)
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  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
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  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
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  • PERK regulates gene expression, organism-specific biosystem (from REACTOME)
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  • Pathways in cancer, organism-specific biosystem (from KEGG)
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  • Pertussis, organism-specific biosystem (from KEGG)
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  • Syndecan-3-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
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  • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
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  • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
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  • Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem (from Pathway Interaction Database)
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chemokine activity TAS
Traceable Author Statement
more info
PubMed 
interleukin-8 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
activation of signaling protein activity involved in unfolded protein response TAS
Traceable Author Statement
more info
 
angiogenesis TAS
Traceable Author Statement
more info
PubMed 
calcium-mediated signaling TAS
Traceable Author Statement
more info
PubMed 
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to fibroblast growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
chemotaxis TAS
Traceable Author Statement
more info
PubMed 
embryonic digestive tract development IEP
Inferred from Expression Pattern
more info
PubMed 
endoplasmic reticulum unfolded protein response TAS
Traceable Author Statement
more info
 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
induction of positive chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
movement of cell or subcellular component TAS
Traceable Author Statement
more info
PubMed 
negative regulation of G-protein coupled receptor protein signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
neutrophil activation TAS
Traceable Author Statement
more info
PubMed 
neutrophil chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of neutrophil chemotaxis TAS
Traceable Author Statement
more info
PubMed 
receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
regulation of single stranded viral RNA replication via double stranded DNA intermediate IDA
Inferred from Direct Assay
more info
PubMed 
response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
response to molecule of bacterial origin IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
interleukin-8
Names
interleukin-8
emoctakin
interleukin 8
T-cell chemotactic factor
neutrophil-activating peptide 1
beta-thromboglobulin-like protein
granulocyte chemotactic protein 1
tumor necrosis factor-induced gene 1
alveolar macrophage chemotactic factor I
monocyte-derived neutrophil chemotactic factor
monocyte-derived neutrophil-activating peptide
small inducible cytokine subfamily B, member 8
lymphocyte derived neutrophil activating peptide
lung giant cell carcinoma-derived chemotactic protein
beta endothelial cell-derived neutrophil activating peptide

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029889.1 

    Range
    5001..8211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000584.3NP_000575.1  interleukin-8 precursor

    See proteins identical to NP_000575.1

    Status: REVIEWED

    Source sequence(s)
    BC013615, BG497712
    Consensus CDS
    CCDS34005.1
    UniProtKB/TrEMBL
    A0A024RDA5
    UniProtKB/Swiss-Prot
    P10145
    Related
    ENSP00000306512, OTTHUMP00000199824, ENST00000307407, OTTHUMT00000322211
    Conserved Domains (1) summary
    cd00273
    Location:3194
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000004.12 

    Range
    73740506..73743716
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 

    Range
    74642243..74645454
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000136.1 

    Range
    70417707..70420917
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    GenBank, FASTA, Sequence Viewer (Graphics)