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MAP1LC3A microtubule-associated protein 1 light chain 3 alpha [ Homo sapiens (human) ]

Gene ID: 84557, updated on 13-Jan-2015
Official Symbol
MAP1LC3Aprovided by HGNC
Official Full Name
microtubule-associated protein 1 light chain 3 alphaprovided by HGNC
Primary source
HGNC:HGNC:6838
Locus tag
RP11-346K17.1
See related
Ensembl:ENSG00000101460; HPRD:03144; MIM:601242; Vega:OTTHUMG00000032306
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LC3; LC3A; ATG8E; MAP1ALC3; MAP1BLC3
Summary
MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]
Orthologs
See MAP1LC3A in MapViewer
Location:
20q11.22
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 20 NC_000020.11 (34546884..34560345)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (33134688..33148149)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene itchy E3 ubiquitin protein ligase Neighboring gene ferredoxin 1 pseudogene 1 Neighboring gene dynein, light chain, roadblock-type 1 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class U Neighboring gene tumor protein p53 inducible nuclear protein 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of nucleolin and modulates the expression of LC3, leading to autophage and cell death of uninfected CD4 T cells PubMed
retropepsin gag-pol HIV-1 protease extensively cleaves microtubule-associated proteins 1 and 2 and completely inhibits microtubule assembly PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
phosphatidylethanolamine binding IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
autophagic vacuole assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
autophagic vacuole assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane fusion IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrion degradation IGI
Inferred from Genetic Interaction
more info
PubMed 
nucleophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
autophagic vacuole IDA
Inferred from Direct Assay
more info
PubMed 
autophagic vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
late endosome IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
organelle membrane IDA
Inferred from Direct Assay
more info
PubMed 
pre-autophagosomal structure IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
microtubule-associated proteins 1A/1B light chain 3A
Names
microtubule-associated proteins 1A/1B light chain 3A
MAP1A/MAP1B LC3 A
MAP1A/1B light chain 3 A
MAP1A/MAP1B light chain 3 A
MAP1 light chain 3-like protein 1
autophagy-related ubiquitin-like modifier LC3 A
microtubule-associated proteins 1A/1B light chain 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032514.3NP_115903.1  microtubule-associated proteins 1A/1B light chain 3A isoform a

    See proteins identical to NP_115903.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (a).
    Source sequence(s)
    AF276658, BP212418, EL954540
    Consensus CDS
    CCDS13238.1
    UniProtKB/Swiss-Prot
    Q9H492
    Conserved Domains (1) summary
    cd01611
    Location:7120
    GABARAP; Ubiquitin domain of GABA-receptor-associated protein
  2. NM_181509.2NP_852610.1  microtubule-associated proteins 1A/1B light chain 3A isoform b

    See proteins identical to NP_852610.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1, resulting in an isoform (b) which has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AF276658, AL118520, BM740344, BP212418
    Consensus CDS
    CCDS13237.1
    UniProtKB/Swiss-Prot
    Q9H492
    Related
    ENSP00000363970, OTTHUMP00000030696, ENST00000374837, OTTHUMT00000078800
    Conserved Domains (1) summary
    cd01611
    Location:18124
    GABARAP; Ubiquitin domain of GABA-receptor-associated protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11 

    Range
    34546884..34560345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260577.1XP_005260634.1  

    See proteins identical to XP_005260634.1

    UniProtKB/Swiss-Prot
    Q9H492
    Related
    ENSP00000353886, OTTHUMP00000030697, ENST00000360668, OTTHUMT00000078801
    Conserved Domains (1) summary
    cd01611
    Location:7120
    GABARAP; Ubiquitin domain of GABA-receptor-associated protein

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 

    Range
    33035525..33048963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000152.1 

    Range
    29915307..29928698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)