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    dnaA chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948217, updated on 16-Jul-2016
    Gene symbol
    dnaA
    Gene description
    chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator
    Primary source
    EcoGene:EG10235
    Locus tag
    b3702
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3694; hsm-2; JW3679
    Summary
    DnaA-ATP is the active form; DnaA-ADP is inactive; switching betwee the two forms modulates initiation activity. [More information is available at EcoGene: EG10235].
    Sequence:
    NC_000913.3 (3882326..3883729, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene gap repair protein Neighboring gene DNA polymerase III, beta subunit Neighboring gene 50S ribosomal subunit protein L34 Neighboring gene protein C5 component of RNase P Neighboring gene membrane protein insertion efficiency factor, UPF0161 family inner membrane protein

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Two-component system, organism-specific biosystem (from KEGG)
      Two-component system, organism-specific biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    • Two-component system, conserved biosystem (from KEGG)
      Two-component system, conserved biosystemTwo-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor ...
    Products Interactant Other Gene Complex Source Pubs Description
    Names
    chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator
    NP_418157.1
    • DNA biosynthesis; initiation of chromosome replication; can be transcription regulator

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3882326..3883729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418157.1 chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418157.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03004
      Conserved Domains (4) summary
      cd06571
      Location:376465
      Bac_DnaA_C; C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple ...
      TIGR00362
      Location:6465
      DnaA; chromosomal replication initiator protein DnaA
      pfam00308
      Location:133350
      Bac_DnaA; Bacterial dnaA protein
      pfam11638
      Location:465
      DnaA_N; DnaA N-terminal domain