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    Rela v-rel avian reticuloendotheliosis viral oncogene homolog A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309165, updated on 25-Jul-2015
    Official Symbol
    Relaprovided by RGD
    Official Full Name
    v-rel avian reticuloendotheliosis viral oncogene homolog Aprovided by RGD
    Primary source
    RGD:727889
    See related
    Ensembl:ENSRNOG00000030888
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NFkB
    Summary
    component of the NF-kappa B complex; involved in transcriptional activation [RGD, Feb 2006]
    Orthologs
    See Rela in MapViewer
    Location:
    1q43
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (220992770..221003249)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (227928092..227938571)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene ribonuclease H2, subunit C Neighboring gene K(lysine) acetyltransferase 5 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene signal-induced proliferation-associated 1 Neighboring gene pecanex-like 3 (Drosophila)

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    NF-kappaB binding IEA
    Inferred from Electronic Annotation
    more info
     
    NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II distal enhancer sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II distal enhancer sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    activating transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ankyrin repeat binding IEA
    Inferred from Electronic Annotation
    more info
     
    ankyrin repeat binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphate ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphate ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-terminus binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    repressing transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    repressing transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    I-kappaB kinase/NF-kappaB signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NIK/NF-kappaB signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acetaldehyde metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interleukin-6 IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interleukin-6 ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to peptide hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to peptide hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    defense response ISO
    Inferred from Sequence Orthology
    more info
     
    hair follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    hair follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    liver development IEA
    Inferred from Electronic Annotation
    more info
     
    liver development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of NIK/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide-binding oligomerization domain containing 2 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Schwann cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-12 biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-12 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of miRNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of miRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    response to UV-B IEA
    Inferred from Electronic Annotation
    more info
     
    response to UV-B ISO
    Inferred from Sequence Orthology
    more info
     
    response to amino acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    response to cAMP IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to cobalamin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to cytokine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to inorganic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to insulin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to morphine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to muramyl dipeptide IEA
    Inferred from Electronic Annotation
    more info
     
    response to muramyl dipeptide ISO
    Inferred from Sequence Orthology
    more info
     
    response to muscle stretch IEA
    Inferred from Electronic Annotation
    more info
     
    response to muscle stretch ISO
    Inferred from Sequence Orthology
    more info
     
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    response to progesterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    I-kappaB/NF-kappaB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NF-kappaB complex IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    transcription factor p65
    Names
    nuclear factor kappa B subunit p65
    v-rel reticuloendotheliosis viral oncogene homolog A

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199267.2NP_954888.1  transcription factor p65

      See identical proteins and their annotated locations for NP_954888.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079457
      UniProtKB/TrEMBL
      Q7TQN4
      Related
      ENSRNOP00000044552, ENSRNOT00000045233
      Conserved Domains (2) summary
      cd07885
      Location:19187
      RHD-n_RelA; N-terminal sub-domain of the Rel homology domain (RHD) of RelA
      cd01177
      Location:194290
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      220992770..221003249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      200460753..200471232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)