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    Ptgs2 prostaglandin-endoperoxide synthase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29527, updated on 28-Jul-2015
    Official Symbol
    Ptgs2provided by RGD
    Official Full Name
    prostaglandin-endoperoxide synthase 2provided by RGD
    Primary source
    RGD:620349
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cox2; COX-2
    Summary
    catalyzes the conversion of arachidonic acid products to prostaglandin; may play a role in response to endotoxic shock; may a role in long term potentiation [RGD, Feb 2006]
    Orthologs
    See Ptgs2 in MapViewer
    Location:
    13q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (67351230..67356920)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (72315959..72324483)

    Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group IVA (cytosolic, calcium-dependent) Neighboring gene uncharacterized LOC100911717 Neighboring gene hypothetical LOC100364450 Neighboring gene phosducin

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    heme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lipid binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    prostaglandin-endoperoxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    prostaglandin-endoperoxide synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to ATP IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to UV IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to fluid shear stress IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to fluid shear stress ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cyclooxygenase pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cyclooxygenase pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    decidualization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    decidualization ISO
    Inferred from Sequence Orthology
    more info
     
    embryo implantation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryo implantation ISO
    Inferred from Sequence Orthology
    more info
     
    hair cycle IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maintenance of blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ovulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell migration involved in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fever generation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fever generation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast growth factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of platelet-derived growth factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transforming growth factor beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of vascular endothelial growth factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    prostaglandin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood pressure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    response to cytokine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to fatty acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to fructose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to lithium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to manganese ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organonitrogen compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    response to radiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to vitamin D IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    NOT nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    prostaglandin G/H synthase 2
    Names
    PGH synthase 2
    PGHS-2
    PHS II
    cyclooxygenase 2
    cyclooxygenase-2
    prostaglandin H2 synthase 2
    NP_058928.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017232.3NP_058928.3  prostaglandin G/H synthase 2 precursor

      See identical proteins and their annotated locations for NP_058928.3

      Status: PROVISIONAL

      Source sequence(s)
      U04300
      UniProtKB/Swiss-Prot
      P35355
      Conserved Domains (3) summary
      cd09816
      Location:75562
      prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
      cd00054
      Location:1955
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam03098
      Location:122568
      An_peroxidase; Animal haem peroxidase

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

      Range
      67351230..67356920
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000081.1 Alternate Rn_Celera

      Range
      62129439..62135131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)