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    Kcna2 potassium voltage-gated channel subfamily A member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25468, updated on 20-Aug-2016
    Official Symbol
    Kcna2provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily A member 2provided by RGD
    Primary source
    RGD:2950
    See related
    Ensembl:ENSRNOG00000018285 Vega:OTTRNOG00000001898
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BK2; NGK1
    Summary
    delayed-rectifier K+ channel expressed in heart and brain [RGD, Feb 2006]
    Orthologs
    Location:
    2q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (209838607..209852471)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (229303490..229316755)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691668 Neighboring gene potassium voltage-gated channel subfamily A member 3 Neighboring gene uncharacterized LOC108350088 Neighboring gene potassium voltage-gated channel subfamily A member 10 Neighboring gene uncharacterized LOC102557194

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    delayed rectifier potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kinesin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    outward rectifier potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    voltage-gated potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    neuronal action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    optic nerve structural organization ISO
    Inferred from Sequence Orthology
    more info
     
    potassium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein oligomerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of circadian sleep/wake cycle, non-REM sleep ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of dopamine secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    axon terminus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    juxtaparanode region of axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    perikaryon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    voltage-gated potassium channel complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    potassium voltage-gated channel subfamily A member 2
    Names
    Potassium (K+) channel protein alpha 2, voltage dependent
    RAK
    RBK2
    RCK5
    potassium channel, voltage gated shaker related subfamily A, member 2
    potassium voltage gated channel shaker related subfamily member 2
    potassium voltage-gated channel, shaker-related subfamily, member 2
    voltage-gated potassium channel subunit Kv1.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012970.3NP_037102.1  potassium voltage-gated channel subfamily A member 2

      See identical proteins and their annotated locations for NP_037102.1

      Status: PROVISIONAL

      Source sequence(s)
      J04731
      UniProtKB/Swiss-Prot
      P63142
      Related
      ENSRNOP00000075852, OTTRNOP00000001811, ENSRNOT00000092450, OTTRNOT00000003108
      Conserved Domains (4) summary
      smart00225
      Location:35118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:212420
      Ion_trans; Ion transport protein
      pfam02214
      Location:35126
      BTB_2; BTB/POZ domain
      pfam07885
      Location:334411
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      209838607..209852471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233133.3XP_006233195.1  

      See identical proteins and their annotated locations for XP_006233195.1

      UniProtKB/Swiss-Prot
      P63142
      Conserved Domains (4) summary
      smart00225
      Location:35118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:212420
      Ion_trans; Ion transport protein
      pfam02214
      Location:35126
      BTB_2; BTB/POZ domain
      pfam07885
      Location:334411
      Ion_trans_2; Ion channel
    2. XM_006233134.3XP_006233196.1  

      See identical proteins and their annotated locations for XP_006233196.1

      UniProtKB/Swiss-Prot
      P63142
      Related
      ENSRNOP00000075841, OTTRNOP00000001821, ENSRNOT00000092365, OTTRNOT00000003123
      Conserved Domains (4) summary
      smart00225
      Location:35118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:212420
      Ion_trans; Ion transport protein
      pfam02214
      Location:35126
      BTB_2; BTB/POZ domain
      pfam07885
      Location:334411
      Ion_trans_2; Ion channel
    3. XM_006233135.3XP_006233197.1  

      See identical proteins and their annotated locations for XP_006233197.1

      UniProtKB/Swiss-Prot
      P63142
      Conserved Domains (4) summary
      smart00225
      Location:35118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:212420
      Ion_trans; Ion transport protein
      pfam02214
      Location:35126
      BTB_2; BTB/POZ domain
      pfam07885
      Location:334411
      Ion_trans_2; Ion channel
    4. XM_008761371.2XP_008759593.1  

      See identical proteins and their annotated locations for XP_008759593.1

      UniProtKB/Swiss-Prot
      P63142
      Conserved Domains (4) summary
      smart00225
      Location:35118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:212420
      Ion_trans; Ion transport protein
      pfam02214
      Location:35126
      BTB_2; BTB/POZ domain
      pfam07885
      Location:334411
      Ion_trans_2; Ion channel
    5. XM_006233132.3XP_006233194.1  

      See identical proteins and their annotated locations for XP_006233194.1

      UniProtKB/Swiss-Prot
      P63142
      Related
      ENSRNOP00000042653, OTTRNOP00000001812, ENSRNOT00000050149, OTTRNOT00000003109
      Conserved Domains (4) summary
      smart00225
      Location:35118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:212420
      Ion_trans; Ion transport protein
      pfam02214
      Location:35126
      BTB_2; BTB/POZ domain
      pfam07885
      Location:334411
      Ion_trans_2; Ion channel

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      187366228..187370362
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)