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    DBR1 RNA lariat debranching enzyme [ Saccharomyces cerevisiae S288c ]

    Gene ID: 853708, updated on 11-Jun-2016
    Gene symbol
    DBR1
    Gene description
    RNA lariat debranching enzyme
    Primary source
    SGD:S000001632
    Locus tag
    YKL149C
    Gene type
    protein coding
    RNA name
    RNA lariat debranching enzyme
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PRP26
    See DBR1 in Map Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (167612..168829, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene NADHX dehydratase Neighboring gene cytochrome-b5 reductase Neighboring gene succinate dehydrogenase flavoprotein subunit SDH1 Neighboring gene Avt3p

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    RNA lariat debranching enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA lariat debranching enzyme activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    RNA phosphodiester bond hydrolysis, endonucleolytic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    snoRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transposition, RNA-mediated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IC
    Inferred by Curator
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    RNA lariat debranching enzyme
    NP_012773.1
    • RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity of RNA-binding proteins TDP-43 and FUS which are implicated in amyotrophic lateral sclerosis (ALS), suggests potential therapeutic target for ALS and related TDP-43 proteinopathies; human homolog DBR1 can complement yeast dbr1 null mutant

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      167612..168829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179715.1NP_012773.1  RNA lariat debranching enzyme [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_012773.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P24309
      Conserved Domains (2) summary
      pfam05011
      Location:294351
      DBR1; Lariat debranching enzyme, C-terminal domain
      cd00844
      Location:6309
      MPP_Dbr1_N; Dbr1 RNA lariat debranching enzyme, N-terminal metallophosphatase domain