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EML4 echinoderm microtubule associated protein like 4 [ Homo sapiens (human) ]

Gene ID: 27436, updated on 7-Aug-2014
Official Symbol
EML4provided by HGNC
Official Full Name
echinoderm microtubule associated protein like 4provided by HGNC
Primary source
HGNC:1316
See related
Ensembl:ENSG00000143924; HPRD:06310; MIM:607442; Vega:OTTHUMG00000128603
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C2orf2; ELP120; EMAP-4; EMAPL4; ROPP120
See EML4 in Epigenomics, MapViewer
Location:
2p21
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (42169350..42332548)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (42396490..42559688)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene chromosome 2 open reading frame 91 Neighboring gene protein kinase domain containing, cytoplasmic Neighboring gene uncharacterized LOC102723824 Neighboring gene cytochrome c oxidase subunit VIIa polypeptide 2 like Neighboring gene voltage-dependent anion channel 1 pseudogene 13 Neighboring gene potassium voltage-gated channel, subfamily G, member 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Non-small cell lung cancer, organism-specific biosystem (from KEGG)
    Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
  • Non-small cell lung cancer, conserved biosystem (from KEGG)
    Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ10942, FLJ32318, DKFZp686P18118

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
microtubule-based process NAS
Non-traceable Author Statement
more info
PubMed 
mitotic nuclear division NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of microtubule depolymerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
echinoderm microtubule-associated protein-like 4
Names
echinoderm microtubule-associated protein-like 4
ropp 120
restrictedly overexpressed proliferation-associated protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145076.1NP_001138548.1  echinoderm microtubule-associated protein-like 4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AF177377, BC146799, DB471322
    Consensus CDS
    CCDS46266.1
    UniProtKB/Swiss-Prot
    Q9HC35
    Conserved Domains (3) summary
    pfam03451
    Location:165240
    Blast Score: 365
    HELP; HELP motif
    COG2319
    Location:235684
    Blast Score: 239
    COG2319; FOG: WD40 repeat [General function prediction only]
    cd00200
    Location:444805
    Blast Score: 278
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_019063.3NP_061936.2  echinoderm microtubule-associated protein-like 4 isoform a

    See proteins identical to NP_061936.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AF177377, DB471322
    Consensus CDS
    CCDS1807.1
    UniProtKB/Swiss-Prot
    Q9HC35
    Related
    ENSP00000320663, OTTHUMP00000158762, ENST00000318522, OTTHUMT00000250463
    Conserved Domains (3) summary
    pfam03451
    Location:223298
    Blast Score: 365
    HELP; HELP motif
    COG2319
    Location:293742
    Blast Score: 241
    COG2319; FOG: WD40 repeat [General function prediction only]
    cd00200
    Location:502863
    Blast Score: 281
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 

    Range
    42169350..42332548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264267.1XP_005264324.1  

    UniProtKB/TrEMBL
    B5MBZ0
    Conserved Domains (3) summary
    pfam03451
    Location:234309
    Blast Score: 361
    HELP; HELP motif
    COG2319
    Location:291753
    Blast Score: 241
    COG2319; FOG: WD40 repeat [General function prediction only]
    cd00200
    Location:513874
    Blast Score: 282
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_006711991.1XP_006712054.1  

    Conserved Domains (3) summary
    pfam03451
    Location:176251
    Blast Score: 361
    HELP; HELP motif
    COG2319
    Location:233695
    Blast Score: 239
    COG2319; FOG: WD40 repeat [General function prediction only]
    cd00200
    Location:455816
    Blast Score: 278
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_005264268.2XP_005264325.1  

    Conserved Domains (4) summary
    pfam03451
    Location:234309
    Blast Score: 361
    HELP; HELP motif
    COG2319
    Location:291753
    Blast Score: 248
    COG2319; FOG: WD40 repeat [General function prediction only]
    cd00200
    Location:467753
    Blast Score: 245
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam00400
    Location:313358
    Blast Score: 84
    WD40; WD domain, G-beta repeat
  4. XM_006711992.1XP_006712055.1  

    Conserved Domains (3) summary
    pfam03451
    Location:155230
    Blast Score: 361
    HELP; HELP motif
    COG2319
    Location:212674
    Blast Score: 243
    COG2319; FOG: WD40 repeat [General function prediction only]
    cd00200
    Location:434795
    Blast Score: 282
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Alternate HuRef

Genomic

  1. AC_000134.1 

    Range
    42130861..42294053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 

    Range
    42326032..42489120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)