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TGFB1 transforming growth factor, beta 1 [ Homo sapiens (human) ]

Gene ID: 7040, updated on 11-Sep-2014
Official Symbol
TGFB1provided by HGNC
Official Full Name
transforming growth factor, beta 1provided by HGNC
Primary source
HGNC:HGNC:11766
See related
Ensembl:ENSG00000105329; HPRD:01821; MIM:190180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CED; LAP; DPD1; TGFB; TGFbeta
Summary
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.[provided by RefSeq, Oct 2009]
See TGFB1 in Epigenomics, MapViewer
Location:
19q13.1
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (41330531..41353933, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41836812..41859831, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 1 Neighboring gene coiled-coil domain containing 97 Neighboring gene B9 protein domain 2 Neighboring gene transmembrane protein 91 Neighboring gene exosome component 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Inactivated HIV or gp120 increases HCV replication and enhances HCV-regulated transforming growth factor (TGF)-beta1 expression PubMed
env HIV-1 gp120-induced apoptosis in human proximal renal tubular cells is significantly enhanced by p300, and Smad7 and an anti-TGF-beta antibody inhibit this effect of p300 PubMed
env HIV-1 gp120 and p300 synergistically increase TGF-beta, ATF-2 and activating protein-1 (AP-1) expression leading to tubular cell apoptosis; in addition, HIV-1 gp120 treatment causes phosphorylation of Smad2 and downregulation of c-Jun PubMed
env HIV-1 gp120-mediated suppression of CD34+ cell growth is entirely due to an upregulation of endogenous TGF-beta 1 PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 induces TGF-beta production in human PBMC PubMed
env HIV-1 gp160 and serum-free macrophage supernatant (MSP) enhance synthesis of type IV collagen by mesangial cells; anti-TGF-beta antibodies attenuate this gp160/MSP-induced collagen synthesis PubMed
Tat tat HIV-1 Tat binds to GLI2 and GLI2 binds to the human TGFB1 promoter, suggesting a potential mechanism for TGFB1 induction in HIV-1 infection PubMed
tat HIV-1 Tat and TGF-beta secretion enhance parasite entry in human macrophages by upregulating surface expression of CD91/LRP-1 PubMed
tat HIV-1 Tat protein permits the survival and replication of a non-pathogenic trypanosomatid in macrophages through TGF-beta1 production PubMed
tat TGF-beta inhibits/down-modulates HIV-1 Tat-induced IL-8 production PubMed
tat HIV-1 Tat upregulation of TGF-beta 1 is likely involved in the regulation of MCP-1 transcription by Tat and the interactions of Tat with Smad-3 and Smad-4, two transcription factors whose activities are induced by the TGF-beta 1 pathway PubMed
tat HIV-1 Tat upregulates TGF-beta 1 expression in a manner involving IL-6, an effect mediated by Tat amino acids 1-48 and potentially associated with immunosuppression, nephropathy, hematopoietic suppression and glomerulosclerosis PubMed
Vpr vpr HIV-1 Vpr impairs NK cell function through cytokine dysregulation, including diminshed expression of CD107a, reduced production of IFN-gamma, differential regulation of IL-12 and TGF-beta, and activation of the Smad3 signalling pathway PubMed
capsid gag Transforming growth factor-beta1 is involved in the enhanced expression of HIV-1 by nicotine, as measured by p24 antigen levels in culture supernatants PubMed

Go to the HIV-1, Human Protein Interaction Database

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  • SMAD2/3 MH2 Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
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  • SMAD2/3 Phosphorylation Motif Mutants in Cancer, organism-specific biosystem (from REACTOME)
    SMAD2/3 Phosphorylation Motif Mutants in Cancer, organism-specific biosystemThe conserved phosphorylation motif Ser-Ser-X-Ser at the C-terminus of SMAD2 and SMAD3 is subject to disruptive mutations in cancer. The last two serine residues in this conserved motif, namely Ser46...
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  • Signaling by TGF-beta Receptor Complex, organism-specific biosystem (from REACTOME)
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  • Signaling by TGF-beta Receptor Complex in Cancer, organism-specific biosystem (from REACTOME)
    Signaling by TGF-beta Receptor Complex in Cancer, organism-specific biosystemSignaling by the TGF-beta receptor complex is tumor suppressive, as it inhibits cell growth and promotes cell differentiation and apoptosis (Shipley et al. 1986, Hannon et al. 1994, Datto et al. 1995...
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  • Syndecan interactions, organism-specific biosystem (from REACTOME)
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  • Syndecan-2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    Syndecan-2-mediated signaling events, organism-specific biosystem
    Syndecan-2-mediated signaling events
  • TCR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TCR Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
  • TFs Regulate miRNAs related to cardiac hypertrophy, organism-specific biosystem (from WikiPathways)
    TFs Regulate miRNAs related to cardiac hypertrophy, organism-specific biosystemTranscription Factors that possibly regulate the expression of microRNAs related to cardiac hypertrophy. Interactions found by using TransMir. MicroRNAs are represented by a purple color and a rounde...
  • TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
  • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
  • TGF-beta receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    TGF-beta receptor signaling, organism-specific biosystem
    TGF-beta receptor signaling
  • TGF-beta receptor signaling activates SMADs, organism-specific biosystem (from REACTOME)
    TGF-beta receptor signaling activates SMADs, organism-specific biosystemBinding of transforming growth factor beta 1 (TGF beta 1, i.e. TGFB1) to TGF beta receptor type 2 (TGFBR2) activates TGF beta receptor signaling cascade. TGFB1 is posttranslationally processed by fur...
  • TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), organism-specific biosystem (from REACTOME)
    TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), organism-specific biosystemIn normal cells and in the early stages of cancer development, signaling by TGF-beta plays a tumor suppressive role, as SMAD2/3:SMAD4-mediated transcription inhibits cell division by downregulating M...
  • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
    TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGF-beta signaling pathway, conserved biosystem (from KEGG)
    TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGFBR1 KD Mutants in Cancer, organism-specific biosystem (from REACTOME)
    TGFBR1 KD Mutants in Cancer, organism-specific biosystemMutations in the kinase domain (KD) of TGF-beta receptor 1 (TGFBR1) have been found in Ferguson-Smith tumor i.e. multiple self-healing squamous epithelioma - MSSE (Goudie et al. 2011), breast cancer ...
  • TGFBR1 LBD Mutants in Cancer, organism-specific biosystem (from REACTOME)
    TGFBR1 LBD Mutants in Cancer, organism-specific biosystemMutations in the ligand-binding domain (LBD) of TGF-beta receptor 1 (TGFBR1) have been reported as germline mutations in Ferguson-Smith tumor (multiple self-healing squamous epithelioma - MSSE), an a...
  • TGFBR2 Kinase Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
    TGFBR2 Kinase Domain Mutants in Cancer, organism-specific biosystemMissense mutations in the kinase domain (KD) of TGF-beta receptor II (TGFBR2) are found in ~20% of microsatellite stable (MSS) colon cancers and make affected tumors resistant to TGF-beta (TGFB1)-med...
  • TGFBR2 MSI Frameshift Mutants in Cancer, organism-specific biosystem (from REACTOME)
    TGFBR2 MSI Frameshift Mutants in Cancer, organism-specific biosystemThe short adenine repeat in the coding sequence of TGF-beta receptor II (TGFBR2) gene is frequently targeted by loss-of-function frameshift mutations in colon cancers with microsatellite instability ...
  • Toxoplasmosis, organism-specific biosystem (from KEGG)
    Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Toxoplasmosis, conserved biosystem (from KEGG)
    Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
    Transcriptional regulation of white adipocyte differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antigen binding IPI
Inferred from Physical Interaction
more info
PubMed 
cytokine activity TAS
Traceable Author Statement
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
glycoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
protein N-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
type II transforming growth factor beta receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
type II transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ATP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 
SMAD protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
SMAD protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
active induction of host immune response by virus TAS
Traceable Author Statement
more info
 
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains IEA
Inferred from Electronic Annotation
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
branch elongation involved in mammary gland duct branching IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
cell growth IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction organization IDA
Inferred from Direct Assay
more info
PubMed 
cellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
 
cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
 
chondrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
common-partner SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
 
connective tissue replacement involved in inflammatory response wound healing TAS
Traceable Author Statement
more info
PubMed 
defense response to fungus, incompatible interaction IEA
Inferred from Electronic Annotation
more info
 
digestive tract development IEA
Inferred from Electronic Annotation
more info
 
embryo development IEA
Inferred from Electronic Annotation
more info
 
endoderm development IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
 
evasion or tolerance of host defenses by virus IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix assembly IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
face morphogenesis IEA
Inferred from Electronic Annotation
more info
 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
frontal suture morphogenesis IEA
Inferred from Electronic Annotation
more info
 
germ cell migration IEA
Inferred from Electronic Annotation
more info
 
hematopoietic progenitor cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
hyaluronan catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response IDA
Inferred from Direct Assay
more info
 
inner ear development IEA
Inferred from Electronic Annotation
more info
 
lens fiber cell differentiation IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 
lymph node development ISS
Inferred from Sequence or Structural Similarity
more info
 
macrophage derived foam cell differentiation IC
Inferred by Curator
more info
PubMed 
mammary gland branching involved in thelarche IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle checkpoint IDA
Inferred from Direct Assay
more info
PubMed 
modulation by virus of host morphology or physiology TAS
Traceable Author Statement
more info
 
mononuclear cell proliferation IEA
Inferred from Electronic Annotation
more info
 
myelination IEA
Inferred from Electronic Annotation
more info
 
myeloid dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extracellular matrix disassembly IC
Inferred by Curator
more info
 
negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
 
negative regulation of hyaluronan biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of macrophage cytokine production IDA
Inferred from Direct Assay
more info
 
negative regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of myoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phagocytosis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 
negative regulation of skeletal muscle tissue development IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
 
organ regeneration IEA
Inferred from Electronic Annotation
more info
 
ossification involved in bone remodeling IEP
Inferred from Expression Pattern
more info
PubMed 
pathway-restricted SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphate-containing compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 
positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of SMAD protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of bone mineralization IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cellular protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of collagen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial to mesenchymal transition NAS
Non-traceable Author Statement
more info
 
positive regulation of exit from mitosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of extracellular matrix assembly IC
Inferred by Curator
more info
 
positive regulation of fibroblast migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of histone acetylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of histone deacetylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-17 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of isotype switching to IgA isotypes IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of odontogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of superoxide anion generation IDA
Inferred from Direct Assay
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation vascular endothelial growth factor production TAS
Traceable Author Statement
more info
PubMed 
protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein import into nucleus, translocation IDA
Inferred from Direct Assay
more info
 
protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of actin cytoskeleton reorganization IEA
Inferred from Electronic Annotation
more info
 
regulation of binding ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of blood vessel remodeling IC
Inferred by Curator
more info
 
regulation of branching involved in mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of cartilage development IEA
Inferred from Electronic Annotation
more info
 
regulation of cell migration TAS
Traceable Author Statement
more info
PubMed 
regulation of miRNA metabolic process IDA
Inferred from Direct Assay
more info
 
regulation of protein import into nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
regulation of striated muscle tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulatory T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
response to cholesterol IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IDA
Inferred from Direct Assay
more info
PubMed 
response to glucose IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to laminar fluid shear stress IEA
Inferred from Electronic Annotation
more info
 
response to progesterone IDA
Inferred from Direct Assay
more info
PubMed 
response to radiation IEA
Inferred from Electronic Annotation
more info
 
response to vitamin D IEA
Inferred from Electronic Annotation
more info
 
response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
salivary gland morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
tolerance induction to self antigen IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
 
ureteric bud development IEA
Inferred from Electronic Annotation
more info
 
viral life cycle TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi lumen TAS
Traceable Author Statement
more info
 
axon IEA
Inferred from Electronic Annotation
more info
 
blood microparticle IDA
Inferred from Direct Assay
more info
 
cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microvillus IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 
proteinaceous extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
transforming growth factor beta-1
Names
transforming growth factor beta-1
TGF-beta-1
latency-associated peptide
prepro-transforming growth factor beta-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013364.1 

    Range
    4994..28396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000660.5NP_000651.3  transforming growth factor beta-1 precursor

    See proteins identical to NP_000651.3

    Status: REVIEWED

    Source sequence(s)
    BC000125, BG115704, X02812
    Consensus CDS
    CCDS33031.1
    UniProtKB/Swiss-Prot
    P01137
    Related
    ENSP00000221930, OTTHUMP00000270088, ENST00000221930, OTTHUMT00000463500
    Conserved Domains (2) summary
    pfam00019
    Location:290390
    Blast Score: 336
    TGF_beta; Transforming growth factor beta like domain
    pfam00688
    Location:28261
    Blast Score: 342
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    41330531..41353933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    38268526..38291927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    41836128..41859502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)