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    Apex1 APEX nuclease (multifunctional DNA repair enzyme) 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79116, updated on 4-Jul-2015
    Official Symbol
    Apex1provided by RGD
    Official Full Name
    APEX nuclease (multifunctional DNA repair enzyme) 1provided by RGD
    Primary source
    RGD:2126
    See related
    Ensembl:ENSRNOG00000009663
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    APE; Apex; REF-1
    Summary
    may play roles in DNA repair and in redox homeostasis; regulates Pax8 transcription [RGD, Feb 2006]
    Orthologs
    See Apex1 in MapViewer
    Location:
    15p14
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (27849943..27852083)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 15 NC_005114.3 (31682368..31684508)

    Chromosome 15 - NC_005114.4Genomic Context describing neighboring genes Neighboring gene kelch-like family member 33 Neighboring gene O-sialoglycoprotein endopeptidase Neighboring gene transmembrane protein 55B Neighboring gene purine nucleoside phosphorylase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    3'-5' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    3'-5' exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA-(apurinic or apyrimidinic site) lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    DNA-(apurinic or apyrimidinic site) lyase activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-(apurinic or apyrimidinic site) lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NF-kappaB binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    damaged DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    double-stranded DNA 3'-5' exodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    endoribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphoric diester hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    poly(A) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    site-specific endodeoxyribonuclease activity, specific for altered base ISO
    Inferred from Sequence Orthology
    more info
     
    site-specific endodeoxyribonuclease activity, specific for altered base ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    DNA demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    DNA demethylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    RNA phosphodiester bond hydrolysis, endonucleolytic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell redox homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to cAMP IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to organonitrogen compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to peptide hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleic acid phosphodiester bond hydrolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleic acid phosphodiester bond hydrolysis ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid phosphodiester bond hydrolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mRNA stability ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organonitrogen compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    DNA-(apurinic or apyrimidinic site) lyase
    Names
    AP endonuclease 1
    APEN
    APEX nuclease 1
    apurinic-apyrimidinic endonuclease 1
    apurinic/apyrimidinic endonuclease 1
    redox factor-1
    NP_077062.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024148.1NP_077062.1  DNA-(apurinic or apyrimidinic site) lyase

      See identical proteins and their annotated locations for NP_077062.1

      Status: PROVISIONAL

      Source sequence(s)
      D44495
      UniProtKB/Swiss-Prot
      P43138
      Related
      ENSRNOP00000013176, ENSRNOT00000013176
      Conserved Domains (1) summary
      cd09087
      Location:61315
      Ape1-like_AP-endo; Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005114.4 Reference Rnor_6.0 Primary Assembly

      Range
      27849943..27852083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251913.1XP_006251975.1  

      See identical proteins and their annotated locations for XP_006251975.1

      UniProtKB/Swiss-Prot
      P43138
      Conserved Domains (1) summary
      cd09087
      Location:61315
      Ape1-like_AP-endo; Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases

    Alternate Rn_Celera

    Genomic

    1. AC_000083.1 Alternate Rn_Celera

      Range
      24464809..24466909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)