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    Hcls1 hematopoietic cell specific Lyn substrate 1 [ Mus musculus (house mouse) ]

    Gene ID: 15163, updated on 4-Sep-2016
    Official Symbol
    Hcls1provided by MGI
    Official Full Name
    hematopoietic cell specific Lyn substrate 1provided by MGI
    Primary source
    MGI:MGI:104568
    See related
    Ensembl:ENSMUSG00000022831 Vega:OTTMUSG00000035773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HS1; AW213261
    Orthologs
    Location:
    16; 16 B
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (36934983..36963214)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (36935069..36963300)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene ELL associated factor 2 Neighboring gene IQ calmodulin-binding motif containing 1 Neighboring gene RIKEN cDNA 4930565N06 gene Neighboring gene golgi autoantigen, golgin subfamily b, macrogolgin 1 Neighboring gene F-box protein 40 Neighboring gene polymerase (DNA directed), theta

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ???? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation...
    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-5 Signaling Pathway, organism-specific biosystem
      IL-5 Signaling Pathway
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA polymerase II transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    SH3 domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of leukocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of granulocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of granulocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of macrophage differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription factor import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tyrosine phosphorylation of STAT protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    response to hormone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    hematopoietic lineage cell-specific protein
    Names
    hematopoietic cell-specific LYN substrate 1
    lckBP1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008225.2NP_032251.2  hematopoietic lineage cell-specific protein

      See identical proteins and their annotated locations for NP_032251.2

      Status: VALIDATED

      Source sequence(s)
      AC154763, AK040049, BX519502, CA321698
      Consensus CDS
      CCDS37336.1
      UniProtKB/Swiss-Prot
      P49710
      UniProtKB/TrEMBL
      Q8CA06
      Related
      ENSMUSP00000023531, OTTMUSP00000050431, ENSMUST00000023531, OTTMUST00000091538
      Conserved Domains (2) summary
      pfam02218
      Location:119154
      HS1_rep; Repeat in HS1/Cortactin
      cl17036
      Location:437485
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      36934983..36963214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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